The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Imprinting evolution and the price of silence
Abstract
In contrast to the biallelic expression of most genes, expression of genes subject to genomic imprinting is monoallelic and based on the sex of the transmitting parent. Possession of only a single active allele can lead to deleterious health consequences in humans. Aberrant expression of imprinted genes, through either genetic or epigenetic alterations, can result in developmental failures, neurodevelopmental and neurobehavioral disorders and cancer. The evolutionary emergence of imprinting occurred in a common ancestor to viviparous mammals after divergence from the egg‐laying monotremes. Current evidence indicates that imprinting regulation in metatherian mammals differs from that in eutherian mammals. This suggests that imprinting mechanisms are evolving from those that were established 150 million years ago. Therefore, comparing genomic sequence of imprinted domains from marsupials and eutherians with those of orthologous regions in monotremes offers a potentially powerful bioinformatics approach for identifying novel imprinted genes and their regulatory elements. Such comparative studies will also further our understanding of the molecular evolution and phylogenetic distribution of imprinted genes. BioEssays 25:577–588, 2003. © 2003 Wiley Periodicals, Inc.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
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Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Genomic imprinting in mammalian development: a parental tug-of-war
Moore, T. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90230-n · Cited by 1,281
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Metastable epialleles in mammals
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M6P/IGF2R Imprinting Evolution in Mammals
Killian, J. K., Byrd, J. C., Jirtle, J. V., Munday, B. L., Stoskopf, M. K., MacDonald, R. G., & Jirtle, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80249-x · Cited by 265
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Cited by
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Self-citationGenome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
Broad Institute Genome Sequencing Platform, Mikkelsen, T. S., Broad Institute Whole Genome Assembly Team, Wakefield, M. J., Aken, B., Amemiya, C. T., Chang, J. L., Duke, S., Garber, M., Gentles, A. J., et al. (2007) · Nature · doi:10.1038/nature05805 · Cited by 711
Self-citationBiochemistry and biology of mammalian DNA methyltransferases
Hermann, A., Gowher, H., & Jeltsch, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4201-1 · Cited by 537
Epigenetic gene regulation: Linking early developmental environment to adult disease
Dolinoy, D. C., Weidman, J. R., & Jirtle, R. L. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.08.012 · Cited by 498
Self-citationWhat is an epigenetic transgenerational phenotype?
Skinner, M. K. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.09.001 · Cited by 485
Metadata
- Authors
- Murphy, S. K., & Jirtle, R. L.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2003-05-19
- Volume
- 25
- Issue
- 6
- Pages
- 577-588
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2162941660
- Cited by
- 234
- References
- 7
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
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