The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
Abstract
One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐translational modification of nuclear proteins with poly(ADP‐ribose) from NAD+ as precursor, mostly catalysed by poly(ADP‐ribose) polymerase‐1 (PARP‐1). Recently several other polypeptides have been shown to catalyse poly(ADP‐ribose) formation. Poly(ADP‐ribosyl)ation is involved in a variety of physiological and pathophysiological phenomena. Physiological functions include its participation in DNA‐base excision repair, DNA‐damage signalling, regulation of genomic stability, and regulation of transcription and proteasomal function, supporting the previously observed correlation of cellular poly(ADP‐ribosyl)ation capacity with mammalian life. The pathophysiology effects are mediated through PARP‐1 overactivity, which can cause cell suicide by NAD+ depletion. It is apparent that the latter effect underlies the pathogenesis of a wide range of disease states including type‐1 diabetes, ischaemic infarcts in various organs, and septic or haemorrhagic shock. Therefore pharmacological modulation of poly(ADP‐ribosyl)ation may prove to be an exciting option for various highly prevalent, disabling and even lethal diseases. BioEssays 23:795–806, 2001. © 2001 John Wiley & Sons, Inc.
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Cites
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
Garcia Soriano, F., Virág, L., Jagtap, P., Szabó, É., Mabley, J. G., Liaudet, L., Marton, A., Hoyt, D. G., Murthy, K. G. K., Salzman, A. L., et al. (2001) · Nature Medicine · doi:10.1038/83241 · Cited by 603
Mitotic Misregulation and Human Aging
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Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins
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Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
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Tankyrase promotes telomere elongation in human cells
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Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers
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Self-citation
Cited by
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
Virág, L., & Szabó, C. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.375 · Cited by 1,373
Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal
Kim, M. Y., Zhang, T., & Kraus, W. L. (2005) · Genes & Development · doi:10.1101/gad.1331805 · Cited by 802
Bieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750
Audebert, M., Salles, B., & Calsou, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404524200 · Cited by 707
Metadata
- Authors
- Bürkle, A.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2001-08-27
- Volume
- 23
- Issue
- 9
- Pages
- 795-806
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1844286590
- Cited by
- 335
- References
- 60
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
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