The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal
Open accessAbstract
Poly(ADP-ribose) (PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable attention in the recent literature. Poly(ADP-ribosyl)ation (PARylation) plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function. These processes are critical for many physiological and pathophysiological outcomes, including genome maintenance, carcinogenesis, aging, inflammation, and neuronal function. This review highlights recent work on the biochemistry, molecular biology, physiology, and pathophysiology of PARylation, focusing on the activity of PARP-1, the most abundantly expressed member of a family of PARP proteins. In addition, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1 are discussed.
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Cites
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
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Self-citationRosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952
Metadata
- Authors
- Kim, M. Y., Zhang, T., & Kraus, W. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-09-01
- Volume
- 19
- Issue
- 17
- Pages
- 1951-1967
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2168268248
- Cited by
- 802
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kim, M. Y., Zhang, T., & Kraus, W. L. (2005). Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal. Genes & Development. https://doi.org/10.1101/gad.1331805
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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