Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
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NAD+ is a limiting metabolite for poly(ADP-ribose) polymerases, which are central DNA damage response proteins.
“In addition to its critical role in organismal health and mitochondrial physiology, NAD+ is a rate-limiting metabolite for the poly(ADP-ribose) polymerases (PARPs)81, which are key DDR proteins.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [81]
Cites
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NAD+ and sirtuins in aging and disease
Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481 · see citing works
PARP inhibition: PARP1 and beyond
Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H., & Poirier, G. G. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2812 · Cited by 1,298 · see citing works
State-of-the-art strategies for targeting the DNA damage response in cancer
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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.002 · Cited by 1,061 · see citing works
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
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Parthanatos, a messenger of death
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“(7) as nicotinamide mononucleotide (NMD)-induced and involving DNA-dependent incorporation of ATP into a nuclear extract with poly-adenine as the possible product.”
BackgroundTargeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433 · see citing works
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Poly(ADP-ribose) signaling in cell death
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Coordination of DNA single strand break repair
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NAD and the aging process: role in life, death and everything in between
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NAD+ biosynthesis, aging, and disease
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NAD<sup>+</sup>metabolism and oxidative stress: the golden nucleotide on a crown of thorns
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- Authors
- Chambon, P., Weill, J. D., & Mandel, P.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1963-04
- Volume
- 11
- Issue
- 1
- Pages
- 39-43
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2005458257
- Cited by
- 654
- References
- 10
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 23 · 2023: 28 · 2022: 41 · 2021: 27 · 2020: 38 · 2019: 27 · 2018: 28 · 2017: 24 · 2016: 25 · 2015: 29 · 2014: 27 · 2013: 38 · 2012: 20
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Keywords
- PARP1, nicotinamide mononucleotide, biomineralization, calcium phosphate, phosphate groups, tumor markers
- MeSH terms
- Adenine Nucleotides, Adenosine Triphosphate, Cell Nucleus, DNA, Liver, Metabolism, Niacin, Niacinamide, Nicotinamide Mononucleotide, Nucleotides, Poly A
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