The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition
Abstract
Several molecular mechanisms contribute directly and mechanically to the loss of epithelial phenotype. During epithelial–mesenchymal transition (EMT), adherens junctions and desmosomes are at least partially dissociated. At the same time, a massive cytoskeleton reorganization takes place, involving the rho family and the remodeling of the actin microfilament mesh. Numerous pathways have been described in vitro that control phenotype transition in specific cell models. In vivo developmental studies suggest that transcriptional control, activated by a specific pathway involving Ras, Src and potentially the Wnt pathway, is an essential step. Recent functional and localization experiments indicate that the slug/snail family of transcription factors functions overall as an epithelial phenotype repressor and could represent a key EMT contributor. BioEssays 23:912–923, 2001. © 2001 John Wiley & Sons, Inc.
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Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
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Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272
Long Noncoding RNAs with Enhancer-like Function in Human Cells
Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytnicki, M., Notredame, C., Huang, Q., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.001 · Cited by 1,721
Building epithelial architecture: insights from three-dimensional culture models
O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596
The transcriptional control of trunk neural crest induction, survival, and delamination
Cheung, M., Chaboissier, M.-C., Mynett, A., Hirst, E., Schedl, A., & Briscoe, J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.010 · Cited by 427
Metadata
- Authors
- Savagner, P.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2001-09-25
- Volume
- 23
- Issue
- 10
- Pages
- 912-923
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2013480667
- Cited by
- 679
- References
- 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
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