The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
The granulin gene family: from cancer to dementia
Abstract
The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif. With PGRN family members in plants and slime mold, it represents one of the most ancient of the extracellular regulatory proteins still extant in modern animals. PRGN has multiple biological roles. It contributes to the regulation of early embryogenesis, to adult tissue repair and inflammation. Elevated PGRN levels often occur in cancers, and PGRN immunotherapy inhibits the growth of hepatic cancer xenografts in mice. Recent studies have demonstrated roles for PGRN in neurobiology. An autosomal dominant mutation in GRN, the gene for PGRN, leads to neuronal atrophy in the frontal and temporal lobes, resulting in the disease frontotemporal lobar dementia. In this review we will discuss current knowledge of the multifaceted biology of PGRN.
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Cited by
Tang, W., Lu, Y., Tian, Q.-Y., Zhang, Y., Guo, F.-J., Liu, G.-Y., Syed, N. M., Lai, Y., Lin, E. A., Kong, L., et al. (2011) · Science · doi:10.1126/science.1199214 · Cited by 761
Breast cancer as a systemic disease: a view of metastasis
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Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage
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Progranulin, lysosomal regulation and neurodegenerative disease
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Metadata
- Authors
- Bateman, A., & Bennett, H. P. J.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2009-10-21
- Volume
- 31
- Issue
- 11
- Pages
- 1245-1254
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2072394256
- Cited by
- 337
- References
- 97
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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