The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Warburg effect then and now: From cancer to inflammatory diseases
Open accessAbstract
Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to rapidly provide ATP and metabolic intermediates for the biosynthesis of immune and inflammatory proteins. In addition, a rise in certain tricarboxylic acid cycle intermediates occurs notably in citrate for lipid biosynthesis, and succinate, which activates the transcription factor Hypoxia‐inducible factor. In this review we take a look at the emerging evidence for a role for the Warburg effect in the immune and inflammatory responses. The reprogramming of metabolic pathways in macrophages, dendritic cells, and T cells could have relevance in the pathogenesis of inflammatory and metabolic diseases and might provide novel therapeutic strategies.
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Cites
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
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Self-citationOtto Warburg's contributions to current concepts of cancer metabolism
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“Succinate elevation from the TCA cycle has a negative feedback effect on PHDs, hence stabilizing Hif-1a [19].”
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Tlr signalling augments macrophage bactericidal activity through mitochondrial ros
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Cited by
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Metabolic regulation of gene expression by histone lactylation
Zhang, D., Tang, Z., Huang, H., Zhou, G., Cui, C., Weng, Y., Liu, W., Kim, S., Lee, S., Perez-Neut, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1678-1 · Cited by 4,371
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876
Self-citationThe immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
Hypoxia, oxidative stress and inflammation
McGarry, T., Biniecka, M., Veale, D. J., & Fearon, U. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.042 · Cited by 601
Metadata
- Authors
- Palsson‐McDermott, E. M., & O'Neill, L. A. J.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2013-09-20
- Volume
- 35
- Issue
- 11
- Pages
- 965-973
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1571252195
- Cited by
- 537
- References
- 18
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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