Telomeres and Aging

Aubert, Geraldine; Lansdorp, Peter M.

doi:10.1152/physrev.00026.2007

Cited by 1,188Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

Telomeres and Aging

Aubert, Geraldine, Lansdorp, Peter M.·2008·Physiological Reviews

DOI 10.1152/physrev.00026.2007

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Abstract

Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must “cap” each chromosome end to avoid activation of DNA repair pathways. Repair of critically short or “uncapped” telomeres by telomerase or recombination is limited in most somatic cells and apoptosis or cellular senescence is triggered when too many “uncapped” telomeres accumulate. The chance of the latter increases as the average telomere length decreases. The average telomere length is set and maintained in cells of the germline which typically express high levels of telomerase. In somatic cells, telomere length is very heterogeneous but typically declines with age, posing a barrier to tumor growth but also contributing to loss of cells with age. Loss of (stem) cells via telomere attrition provides strong selection for abnormal and malignant cells, a process facilitated by the genome instability and aneuploidy triggered by dysfunctional telomeres. The crucial role of telomeres in cell turnover and aging is highlighted by patients with 50% of normal telomerase levels resulting from a mutation in one of the telomerase genes. Short telomeres in such patients are implicated in a variety of disorders including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis, and cancer. Here the role of telomeres and telomerase in human aging and aging-associated diseases is reviewed.

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“the involvement of telomere shortening in the functional decline of HSC is particularly evident in human”
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Site-Specific DNA Damage at the GGG Sequence by UVA Involves Acceleration of Telomere Shortening
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TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression
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TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
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The Human Rap1 Protein Complex and Modulation of Telomere Length
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Telomerase levels control the lifespan of human T lymphocytes
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TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
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Dyskeratosis Congenita - A Disease of Dysfunctional Telomere Maintenance
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“Short telomeres are a risk factor in the progression of ulcerative colitis to colon carcinoma (161) and in nonalcoholic fatty liver disease (157), liver cirrhosis (138), and pulmonary fibrosis (6).”
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Accelerated telomere shortening and telomerase activation in Fanconi's anaemia
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Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation
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Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer
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Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111 · see citing works
Virus-Induced CD8+ T Cell Clonal Expansion Is Associated with Telomerase Up-Regulation and Telomere Length Preservation: A Mechanism for Rescue from Replicative Senescence
Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N., & Beverley, P. C. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4521 · Cited by 110 · see citing works
The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection
Plunkett, F. J., Soares, M. V. D., Annels, N. E., Hislop, A. D., Ivory, K., Lowdell, M. W., Salmon, M., Rickinson, A. B., & Akbar, A. N. (2001) · Blood · doi:10.1182/blood.v97.3.700 · Cited by 109 · see citing works
Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice
González-Suárez, E., Geserick, C., Flores, J. M., & Blasco, M. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208413 · Cited by 109 · see citing works
Genetic Manipulation of Telomerase in HIV-Specific CD8+ T Cells: Enhanced Antiviral Functions Accompany the Increased Proliferative Potential and Telomere Length Stabilization
Dagarag, M. D., Evazyan, T., Rao, N. P., & Effros, R. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6303 · Cited by 107 · see citing works
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress
Rubio, M. Á., Davalos, A. R., & Campisi, J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.004 · Cited by 105 · see citing works
Functional characterization of natural telomerase mutations found in patients with hematologic disorders
Xin, Z.-T., Beauchamp, A. D., Calado, R. T., Bradford, J. W., Regal, J. A., Shenoy, A. G., Liang, Y., Lansdorp, P. M., Young, N. S., & Ly, H. (2006) · Blood · doi:10.1182/blood-2006-07-035089 · Cited by 104 · see citing works
Self-citation
Haploinsufficiency of mTR results in defects in telomere elongation
Hathcock, K. S., Hemann, M. T., Opperman, K., Strong, M. A., Greider, C. W., & Hodes, R. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012549799 · Cited by 102 · see citing works
Early Replication of Short Telomeres in Budding Yeast
Bianchi, A., & Shore, D. (2007) · Cell · doi:10.1016/j.cell.2007.01.041 · Cited by 101 · see citing works
Telomere Length in Human Natural Killer Cell Subsets
Ouyang, Q., Baerlocher, G. M., Vulto, I. M., & Lansdorp, P. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1392.001 · Cited by 99 · see citing works
Self-citation
Major cutbacks at chromosome ends
Lansdorp, P. M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.004 · Cited by 99 · see citing works
Self-citation
WRN at telomeres: implications for aging and cancer
Multani, A. S., & Chang, S. (2007) · Journal of Cell Science · doi:10.1242/jcs.03397 · Cited by 95 · see citing works
Accelerated Telomere Shortening in the Human Inactive X Chromosome
Surrallés, J., Hande, M. P., Marcos, R., & Lansdorp, P. M. (1999) · The American Journal of Human Genetics · doi:10.1086/302665 · Cited by 94 · see citing works
Self-citation
Telomere maintenance in human B lymphocytes
Martens, U. M., Brass, V., Sedlacek, L., Pantić, M., Exner, C., Guo, Y., Engelhardt, M. M., Lansdorp, P. M., Waller, C. F., & Lange, W. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03910.x · Cited by 94 · see citing works
Self-citation
Two retrotransposons maintain telomeres in Drosophila
Pardue, M. L., Rashkova, S., Casacuberta, E., DeBaryshe, P. G., George, J. A., & Traverse, K. L. (2005) · Chromosome Research · doi:10.1007/s10577-005-0993-6 · Cited by 91 · see citing works
Dynamics of Protein Binding to Telomeres in Living Cells: Implications for Telomere Structure and Function
Mattern, K. A., Swiggers, S. J. J., Nigg, A. L., Löwenberg, B., Houtsmuller, A. B., & Zijlmans, J. M. J. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5587-5594.2004 · Cited by 90 · see citing works
Constitutive Expression of Tert in Thymocytes Leads to Increased Incidence and Dissemination of T-Cell Lymphoma in Lck-Tert Mice
Canela, A., Martín-Caballero, J., Flores, J. M., & Blasco, M. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4275-4293.2004 · Cited by 90 · see citing works
Telomerase RNA Mutated in Autosomal Dyskeratosis Congenita Reconstitutes a Weakly Active Telomerase Enzyme Defective in Telomere Elongation
Cerone, M. A., Ward, R. J., Londoño‐Vallejo, A., & Autexier, C. (2005) · Cell Cycle · doi:10.4161/cc.4.4.1586 · Cited by 87 · see citing works
Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes
Dagarag, M. D., Ng, H. L., Lubong, R., Effros, R. B., & Yang, O. O. (2003) · Journal of Virology · doi:10.1128/jvi.77.5.3077-3083.2003 · Cited by 85 · see citing works
Functional characterization of telomerase RNA variants found in patients with hematologic disorders
Ly, H., Calado, R. T., Allard, P., Baerlocher, G. M., Lansdorp, P. M., Young, N. S., & Parslow, T. G. (2004) · Blood · doi:10.1182/blood-2004-09-3659 · Cited by 84 · see citing works
Self-citation
Self-Renewal of Stem Cells
Lansdorp, P. M. (1998) · Humana Press eBooks · doi:10.1007/978-1-4757-2778-4_2 · Cited by 82 · see citing works
Self-citation
Telomere Length Dynamics in Normal Individuals and in Patients with Hematopoietic Stem Cell‐Associated Disorders
Brümmendorf, T. H., Rufer, N., Holyoake, T. L., MACIEJEWSKI, J., BARNETT, M. J., Eaves, C. J., Eaves, A. C., Young, N. S., & Lansdorp, P. M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03598.x · Cited by 82 · see citing works
Self-citation
Living forever and dying in the attempt
Hayflick, L. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.003 · Cited by 82 · see citing works
Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte Immortalization
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The social determinants of health: It’s time to consider the causes of the causes
Braveman, P., & Gottlieb, L. (2014) · Public Health Reports® · doi:10.1177/00333549141291s206 · Cited by 3,861 · see citing works
Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
Rahal, A., Kumar, A., Singh, V., Yadav, B., Tiwari, R., Chakraborty, S., & Dhama, K. (2014) · BioMed Research International · doi:10.1155/2014/761264 · Cited by 1,730 · see citing works
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303607110 · Cited by 1,368 · see citing works
RETRACTED: Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
Bolli, R., Chugh, A. R., D’Amario, D., Loughran, J. H., Stoddard, M. F., Ikram, S., Beache, G. M., Wagner, S. G., Leri, A., Hosoda, T., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61590-0 · Cited by 1,287 · see citing works
Retracted
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R. G., & Eguchi, S. (2018) · Physiological Reviews · doi:10.1152/physrev.00038.2017 · Cited by 1,106 · see citing works
Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
Sanders, J. L., & Newman, A. B. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs008 · Cited by 541 · see citing works
TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL
Yan, H., Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H. S., Gallia, G. L., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou206.18 · Cited by 530 · see citing works
Renal Aging: Causes and Consequences
O’Sullivan, E. D., Hughes, J., & Ferenbach, D. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121308 · Cited by 484 · see citing works
The association of telomere length and cancer: a meta-analysis
Wentzensen, I. M., Mirabello, L., Pfeiffer, R. M., & Savage, S. A. (2011) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0005 · Cited by 458 · see citing works
Aging of hematopoietic stem cells
de Haan, G., & Lazare, S. S. (2018) · Blood · doi:10.1182/blood-2017-06-746412 · Cited by 432 · see citing works
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
Sharma, R. K., Agarwal, A. K., Rohra, V. K., Assidi, M., Abu-Elmagd, M. M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 469 · see citing works
Is Telomere Length a Biomarker of Aging? A Review
Mather, K. A., Jorm, A. F., Parslow, R., & Christensen, H. M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq180 · Cited by 442 · see citing works
Ageing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386 · see citing works
Axis of ageing: telomeres, p53 and mitochondria
Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works
Vascular Aging
Nilsson, P. M., Boutouyrie, P., & Laurent, S. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.129114 · Cited by 381 · see citing works
Genome Instability and Aging
Vijg, J., & Suh, Y. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183715 · Cited by 386 · see citing works
Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies
Nelson, P. T., Head, E., Schmitt, F. A., Davis, P. R., Neltner, J. H., Jicha, G. A., Abner, E. L., Smith, C. D., Van Eldik, L. J., Kryscio, R. J., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0826-y · Cited by 365 · see citing works
Embryonic exposure to corticosterone modifies the juvenile stress response, oxidative stress and telomere length
Haussmann, M. F., Longenecker, A. S., Marchetto, N. M., Juliano, S. A., & Bowden, R. M. (2011) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2011.1913 · Cited by 357 · see citing works
IPF lung fibroblasts have a senescent phenotype
Álvarez, D., Cárdenes, N., Sellarés, J., Bueno, M., Corey, C., Hanumanthu, V. S., Peng, Y., D’Cunha, H., Sembrat, J., Nouraie, M., et al. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00220.2017 · Cited by 342 · see citing works
Telomere length measurement-caveats and a critical assessment of the available technologies and tools
Aubert, G., Hills, M., & Lansdorp, P. M. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.04.003 · Cited by 342 · see citing works
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
Ferguson, L. R., Chen, H., Collins, A. R., Connell, M., Damia, G. L. M., Dasgupta, S., Malhotra, M., Meeker, A. K., Amedei, A., Amin, A., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.005 · Cited by 340 · see citing works
EORTC elderly task force position paper: Approach to the older cancer patient
Pallis, A. G., Fortpied, C., Wedding, U., Nes, M.-C. V., Penninckx, B., Ring, A. E., Lacombe, D., Monfardini, S., Scalliet, P. G. M., & Wildiers, H. P. M. W. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.022 · Cited by 339 · see citing works
Telomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339 · see citing works
Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999–2002
Needham, B. L., Adler, N. E., Gregorich, S. E., Rehkopf, D. H., Lin, J., Blackburn, E. H., & Epel, E. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.023 · Cited by 325 · see citing works
Syndromes of Telomere Shortening
Armanios, M. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082908-150046 · Cited by 317 · see citing works
Telomere Length and All-Cause Mortality: A Meta-analysis
Wang, Q., Zhan, Y., Pedersen, N. L., Fang, F., & Hägg, S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.002 · Cited by 322 · see citing works
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
Teschendorff, A. E., West, J., & Beck, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt375 · Cited by 318 · see citing works
Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket
Donnelly, A. C., & Blagg, B. S. J. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708786242895 · Cited by 314 · see citing works
Leukocyte telomere length and mortality in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Kimura, M., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Hardikar, S., & Aviv, A. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq224 · Cited by 271 · see citing works
Telomere biology in healthy aging and disease
Oeseburg, H., de Boer, R. A., van Gilst, W. H., & van der Harst, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0728-1 · Cited by 273 · see citing works
Depression and telomere length: a meta-analysis
Ridout, K. K., Ridout, S. J., Price, L. H., Sen, S., & Tyrka, A. R. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.052 · Cited by 258 · see citing works
Persistent γH2AX: A promising molecular marker of DNA damage and aging
Siddiqui, M. S., François, M., Fenech, M. F., & Leifert, W. R. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.07.001 · Cited by 266 · see citing works
Discrimination, Racial Bias, and Telomere Length in African-American Men
Chae, D. H., Nuru‐Jeter, A., Adler, N. E., Brody, G. H., Lin, J., Blackburn, E. H., & Epel, E. S. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.10.020 · Cited by 263 · see citing works
Dyskeratosis Congenita
Savage, S. A., & Alter, B. P. (2009) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2009.01.003 · Cited by 262 · see citing works
Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology
Tyrka, A. R., Parade, S. H., Price, L. H., Kao, H.-T., Porton, B., Philip, N. S., Welch, E. S., & Carpenter, L. L. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.025 · Cited by 259 · see citing works
The genetics and clinical manifestations of telomere biology disorders
Savage, S. A., & Bertuch, A. A. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181f415b5 · Cited by 257 · see citing works
Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes
Aubert, G., Baerlocher, G. M., Vulto, I. M., Poon, S. S. S., & Lansdorp, P. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002696 · Cited by 257 · see citing works
Self-citation
Telomere shortening and survival in free-living corvids
Salomons, H. M., Mulder, G. A., van de Zande, L., Haussmann, M. F., Linskens, M. H. K., & Verhulst, S. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.0517 · Cited by 257 · see citing works
Telomeres and life histories: the long and the short of it
Monaghan, P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05705.x · Cited by 253 · see citing works
A Spectrum of Severe Familial Liver Disorders Associate with Telomerase Mutations
Calado, R. T., Regal, J. A., Kleiner, D. E., Schrump, D. S., Peterson, N. R., Pons, V., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007926 · Cited by 252 · see citing works
Self-citation
The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer
Mirabello, L. J., Huang, W., Wong, J. Y. Y., Chatterjee, N., Reding, D. J., Crawford, E. D., Vivo, I. D., Hayes, R. B., & Savage, S. A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00485.x · Cited by 246 · see citing works
RETRACTED: Chronic Inflammation: Accelerator of Biological Aging
Fougère, B., Boulanger, É., Nourhashémi, F., Guyonnet, S., & Cesari, M. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw240 · Cited by 247 · see citing works
Retracted
Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences
Monaghan, P., & Ozanne, S. E. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0446 · Cited by 241 · see citing works
TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas
Simon, M., Hosen, M. I., Gousias, K., Rachakonda, P. S., Heidenreich, B., Gessi, M., Schramm, J., Hemminki, K., Waha, A., & Kumar, R. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou158 · Cited by 234 · see citing works
Telomere length is associated with disease severity and declines with age in dyskeratosis congenita
Alter, B. P., Rosenberg, P. S., Giri, N., Baerlocher, G. M., Lansdorp, P. M., & Savage, S. A. (2012) · Haematologica · doi:10.3324/haematol.2011.055269 · Cited by 238 · see citing works
Self-citation
Organismal stress, telomeres and life histories
Monaghan, P. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.090043 · Cited by 233 · see citing works
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth
Marian, C. O., Cho, S. K., Mcellin, B. M., Maher, E. A., Hatanpaa, K. J., Madden, C. J., Mickey, B., Wright, W. E., Shay, J. W., & Bachoo, R. M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2850 · Cited by 220 · see citing works
Telomere Dynamics in Mice and Humans
Calado, R. T., & Dumitriu, B. (2013) · Seminars in Hematology · doi:10.1053/j.seminhematol.2013.03.030 · Cited by 214 · see citing works
Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications
Suseela, Y. V., Narayanaswamy, N., Pratihar, S., & Govindaraju, T. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00774d · Cited by 222 · see citing works
An Integrative Review of Factors Associated with Telomere Length and Implications for Biobehavioral Research
Starkweather, A. R., Alhaeeri, A. A., Montpetit, A. J., Brumelle, J., Filler, K., Montpetit, M., Mohanraj, L., Lyon, D., & Jackson‐Cook, C. K. (2013) · Nursing Research · doi:10.1097/nnr.0000000000000009 · Cited by 217 · see citing works
Combined analysis of TERT , EGFR , and IDH status defines distinct prognostic glioblastoma classes
Labussière, M., Boisselier, B., Mokhtari, K., Stefano, A. L. D., Rahimian, A., Rossetto, M., Ciccarino, P., Saulnier, O., Paterra, R., Marie, Y., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000814 · Cited by 217 · see citing works
An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effects
Eisenberg, D. T. A. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21127 · Cited by 208 · see citing works
Measuring telomere length and telomere dynamics in evolutionary biology and ecology
Nussey, D. H., Baird, D. M., Barrett, E. L. B., Boner, W., Fairlie, J., Gemmell, N. J., Hartmann, N., Horn, T., Haussmann, M. F., Olsson, M. M., et al. (2014) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12161 · Cited by 203 · see citing works
TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
Labussière, M., Stefano, A. L. D., Gleize, V., Boisselier, B., Giry, M., Mangesius, S., Bruno, A., Paterra, R., Marie, Y., Rahimian, A., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.538 · Cited by 201 · see citing works
Telomeres: Linking stress and survival, ecology and evolution
Haussmann, M. F., & Marchetto, N. M. (2010) · Current Zoology · doi:10.1093/czoolo/56.6.714 · Cited by 193 · see citing works
Telomere length and cortisol reactivity in children of depressed mothers
Gotlib, I. H., LeMoult, J., Colich, N. L., Foland-Ross, L. C., Hallmayer, J., Joormann, J., Lin, J., & Wolkowitz, O. M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.119 · Cited by 186 · see citing works
Firm age: a survey
Coad, A. (2016) · Journal of Evolutionary Economics · doi:10.1007/s00191-016-0486-0 · Cited by 198 · see citing works
Long-term exposure to air pollution is associated with biological aging
Ward-Caviness, C. K., Nwanaji‐Enwerem, J. C., Wolf, K., Wahl, S., Colicino, E., Trevisi, L., Kloog, I., Just, A. C., Vokonas, P., Cyrys, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12903 · Cited by 191 · see citing works
The fetal programming of telomere biology hypothesis: an update
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Authors: Aubert, G., & Lansdorp, P. M.
Affiliations: BC Cancer Agency (CA)
ORCID: Lansdorp, Peter M.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2008-04
Volume: 88
Issue: 2
Pages: 557-579
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00026.2007
OpenAlex: W2134718821
Semantic Scholar: 8bad1c1721d1f3aeafe2340ffa70004f3d15bd94
Cited by: 1,188
References: 240
Citations by year: 2026: 33 · 2025: 43 · 2024: 86 · 2023: 61 · 2022: 70 · 2021: 94 · 2020: 98 · 2019: 79 · 2018: 63 · 2017: 70 · 2016: 63 · 2015: 76 · 2014: 70 · 2013: 66 · 2012: 48
FWCI: 6.01
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI 29524)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: telomeres, aging, telomerase, cellular senescence, apoptosis, telomere shortening, genomic instability, aneuploidy, dyskeratosis congenita, aplastic anemia, pulmonary fibrosis, cancer, telomere length, age-related diseases
MeSH terms: Aging, Humans, Telomere, Telomerase

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