The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The relationship between non‐protein‐coding DNA and eukaryotic complexity
Abstract
There are two intriguing paradoxes in molecular biology—the inconsistent relationship between organismal complexity and (1) cellular DNA content and (2) the number of protein‐coding genes—referred to as the C‐value and G‐value paradoxes, respectively. The C‐value paradox may be largely explained by varying ploidy. The G‐value paradox is more problematic, as the extent of protein coding sequence remains relatively static over a wide range of developmental complexity. We show by analysis of sequenced genomes that the relative amount of non‐protein‐coding sequence increases consistently with complexity. We also show that the distribution of introns in complex organisms is non‐random. Genes composed of large amounts of intronic sequence are significantly overrepresented amongst genes that are highly expressed in the nervous system, and amongst genes downregulated in embryonic stem cells and cancers. We suggest that the informational paradox in complex organisms may be explained by the expansion of cis‐acting regulatory elements and genes specifying trans‐acting non‐protein‐coding RNAs. BioEssays 29: 288–299, 2007. © 2007 Wiley Periodicals, Inc.
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Cites
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Cited by
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Self-citationLong non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
The Emergence of lncRNAs in Cancer Biology
Prensner, J. R., & Chinnaiyan, A. M. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0209 · Cited by 1,770
Specific expression of long noncoding RNAs in the mouse brain
Mercer, T. R., Dinger, M. E., Sunkin, S. M., Mehler, M. F., & Mattick, J. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706729105 · Cited by 1,103
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Metadata
- Authors
- Taft, R. J., Pheasant, M., & Mattick, J. S.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2007-02-12
- Volume
- 29
- Issue
- 3
- Pages
- 288-299
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2128731054
- Cited by
- 700
- References
- 16
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
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