The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The diverse functions of Krüppel‐like factors 4 and 5 in epithelial biology and pathobiology
Open accessAbstract
The Krüppel‐like factors (KLFs) comprise a family of evolutionarily conserved zinc finger transcription factors that regulate numerous biological processes including proliferation, differentiation, development and apoptosis. KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues. In the intestinal epithelium, KLF4 is expressed in terminally differentiated epithelial cells at the villus borders of the mucosa and inhibits cell growth, while KLF5 is expressed in proliferating epithelial cells at the base of the intestinal crypts and promotes cell growth. KLF4 and KLF5 respond to a myriad of external stress stimuli and are likely involved in restoring cellular homeostasis following exposure to stressors. Confirming their importance in maintaining tissue integrity, KLF4 and KLF5 are both dysregulated in various types of cancer. Here we review the recent advances in defining the physiological and pathobiological roles of KLF4 and KLF5, focusing on their functions in the intestinal epithelium. BioEssays 29:549–557, 2007. © 2007 Wiley Periodicals, Inc.
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
The biology of the mammalian Krüppel-like family of transcription factors
Dang, D. T., Pevsner, J., & Yang, V. W. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00059-5 · Cited by 458
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Cited by
Mammalian Krüppel-Like Factors in Health and Diseases
McConnell, B. B., & Yang, V. W. (2010) · Physiological Reviews · doi:10.1152/physrev.00058.2009 · Cited by 1,018
Self-citationZinc-finger proteins in health and disease
Cassandri, M., Smirnov, A., Novelli, F., Pitolli, C., Agostini, M., Malewicz, M., Melino, G., & Raschellà, G. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.71 · Cited by 852
Krüppel-like factor 4 (KLF4): What we currently know
Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 523
Self-citationDong, J.-T., & Chen, C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0045-z · Cited by 271
Embryonic stem cell markers expression in cancers
Schoenhals, M., Kassambara, A., Vos, J. D., Hose, D., Moreaux, J., & Klein, B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.156 · Cited by 265
Metadata
- Authors
- McConnell, B. B., Ghaleb, A. M., Nandan, M. O., & Yang, V. W.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2007-05-16
- Volume
- 29
- Issue
- 6
- Pages
- 549-557
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2032869210
- Cited by
- 258
- References
- 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
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