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Cited by 309

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Molecular mechanisms of anti‐inflammatory action of glucocorticoids

Cato, Andrew C. B., Wade, Erik·1996·BioEssays
DOI 10.1002/bies.950180507
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Abstract

Glucocorticoid hormones are effective in controlling inflammation, but the mechanisms that confer this action are largely unknown. Recent advances in this field have shown that both positive and negative regulation of gene expression are necessary for this process. The genes whose activity are modulated in the anti‐inflammatory process code for several cytokines, adhesion molecules and enzymes. Most of them do not carry a classical binding site for regulation by a glucocorticoid receptor, but have instead regulatory sequences for transcription factors such as AP‐1 or NF‐κ. This makes them unusual targets for glucocorticoid action and emphasizes the need for novel regulatory mechanisms. Recent studies describe an important contribution by protein‐protein interactions, in which several domains of the receptor participate; these studies provide a better understanding of the action of the receptor and offer opportunities for the design of steroidal compounds that could function more effectively as anti‐inflammatory drugs.

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Crossref · 10.1002/bies.950180507

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Metadata

Authors
Cato, A. C. B., & Wade, E.
Venue
BioEssays
Publisher
Wiley
Published
1996-05
Volume
18
Issue
5
Pages
371-378
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.950180507
OpenAlex
W2126836839
Cited by
309
References
64
FWCI
2.80
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.