The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Curcumin uptake and metabolism
Abstract
Curcumin (CUR) is the major orange pigment of turmeric and believed to exert beneficial health effects in the gastrointestinal tract and numerous other organs after oral intake. However, an increasing number of animal and clinical studies show that the concentrations of CUR in blood plasma, urine, and peripheral tissues, if at all detectable, are extremely low even after large doses. The evidence and possible reasons for the very poor systemic bioavailablity of CUR after oral administration are discussed in this brief review. Major factors are the chemical instability of CUR at neutral and slightly alkaline pH, its susceptibility to autoxidation, its avid reductive and conjugative metabolism, and its poor permeation from the intestinal lumen to the portal blood. In view of the very low intestinal bioavailablity, it is difficult to attribute the putative effects observed in peripheral organs to CUR. Therefore, metabolites and/or degradation products of CUR should be taken into consideration as mediators of the pharmacological activity. © 2012 BioFactors, 39(1):14–20, 2013.
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Cites
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · cited 2×
“Because of the poor systemic availability of orally administered CUR, numerous efforts have been made to increase oral bioavailability by formulating of CUR with adjuvants, nanoparticles, liposomes, and micelles, as summarized in [21] and dealt with in another article of this volume.”
BackgroundStability of curcumin in buffer solutions and characterization of its degradation products
Wang, Y.-J., Pan, M.-H., Cheng, A.-L., Lin, L.-I., Ho, Y.-S., Hsieh, C.-Y., & Lin, J.-K. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(96)02024-9 · Cited by 1,705
Sharma, R. A., Gescher, A. J., & Steward, W. P. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.05.009 · Cited by 1,658
Dose escalation of a curcuminoid formulation
Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-10 · Cited by 1,394
Phase I Clinical Trial of Oral Curcumin
Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., Marczylo, T. H., Morgan, B., Hemingway, D., Plummer, S. M., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0744 · Cited by 1,257
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature
Anand, P., Thomas, S. G., Kunnumakkara, A. B., Sundaram, C., Harikumar, K. B., Sung, B., Tharakan, S. T., Misra, K., Priyadarsini, I. K., Rajasekharan, K. N., et al. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.08.008 · Cited by 1,205
Yee, S. (1997) · Pharmaceutical Research · doi:10.1023/a:1012102522787 · Cited by 1,030
Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice
Pan, M.-H., Huang, T.-M., & Lin, J.-K. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15211-7 · Cited by 946
Curcumin—From Molecule to Biological Function
Esatbeyoglu, T., Huebbe, P., Ernst, I. M. A., Chin, D., Wagner, A. E., & Rimbach, G. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107724 · Cited by 904
Zhou, H., S. Beevers, C., & Huang, S. (2011) · Current Drug Targets · doi:10.2174/138945011794815356 · Cited by 715
Cited by
Bioactivity of dietary polyphenols: The role of metabolites
Luca, S. V., Macovei, I., Bujor, A., Miron, A., Skalicka-Woźniak, K., Aprotosoaie, A. C., & Trifan, A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546669 · Cited by 718
Lopresti, A. L. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx011 · Cited by 371
Yan, L., Guo, M.-S., Zhang, Y., Yu, L., Wu, J.-M., Tang, Y., Ai, W., Zhu, F.-D., Law, B. Y.-K., Chen, Q., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5288698 · Cited by 97
Curcumin and hesperetin attenuate D-galactose-induced brain senescence in vitro and in vivo
Lee, J., Kim, Y. S., Kim, E., Kim, Y., & Kim, Y. (2020) · Nutrition Research and Practice · doi:10.4162/nrp.2020.14.5.438 · Cited by 41
“Both polyphenols are rapidly metabolized and excreted in urine or feces [61,62].”
Background1,5-Benzodiazepin-2(3H)-ones: In Vitro Evaluation as Antiparkinsonian Agents
Ortíz de Zárate, A., Pérez-Torralba, M., Bonet Isidro, I., López, C., Claramunt, R. M., Martínez-Casanova, D., Sánchez-Vera, I., Jiménez-González, J., & Lavandera, J. L. (2021) · Antioxidants · doi:10.3390/antiox10101584 · Cited by 11
Metadata
- Authors
- Metzler, M., Pfeiffer, E., Schulz, S. I., & Dempe, J. S.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2012-09-20
- Volume
- 39
- Issue
- 1
- Pages
- 14-20
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W1985717888
- Cited by
- 268
- References
- 38
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
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