The mitochondrial permeability transition
Abstract
This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A‐sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Much less is known about the specific molecular sites and conditions for electron leak and O2•− generation along the electron-transport pathway under pathophysiologic conditions.
“Although much is known of the chemistry of ROS (151), much less is known about the specific molecular sites and conditions for electron leak and O2•− generation along the electron-transport pathway under pathophysiologic conditions (32, 61).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [32]
Cites
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145 · see citing works
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works
Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884 · see citing works
Mechanisms by which mitochondria transport calcium
Gunter, T. E., & Pfeiffer, D. R. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c755 · Cited by 1,640 · see citing works
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635 · see citing works
Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.367 · Cited by 1,567 · see citing works
Mitochondrial control of apoptosis
Kroemer, G., Zamzami, N., & Susín, S. A. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80014-x · Cited by 1,492 · see citing works
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,201 · see citing works
Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.5.1661 · Cited by 1,166 · see citing works
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.
Susín, S. A., Zamzami, N., Castedo, M., Hirsch, T., Marchetti, P., Macho, A., Daugas, É., Geuskens, M., & Kroemer, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1331 · Cited by 1,133 · see citing works
The Ca2+-induced membrane transition in mitochondria
Hunter, D. R., & Haworth, R. A. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90371-0 · Cited by 860 · see citing works
Crompton, M., Ellinger, H., & COSTI, A. (1988) · PubMed Central · Cited by 841 · see citing works
The Ca2+-induced membrane transition in mitochondria
Haworth, R. A., & Hunter, D. R. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90372-2 · Cited by 793 · see citing works
Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity
Schinder, A. F., Olson, E. C., Spitzer, N. C., & Montal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06125.1996 · Cited by 770 · see citing works
Ichas, F., Jouaville, L. S., & Mazat, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80301-3 · Cited by 754 · see citing works
Self-citationHalestrap, A. P., & Davidson, A. M. (1990) · Biochemical Journal · doi:10.1042/bj2680153 · Cited by 753 · see citing works
Broekemeier, K. M., Dempsey, M. E., & Pfeiffer, D. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83116-7 · Cited by 699 · see citing works
Ichas, F., & Mazat, J. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00119-4 · Cited by 570 · see citing works
Self-citationBernardi, P., Broekemeier, K. M., & Pfeiffer, D. R. (1994) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762735 · Cited by 561 · see citing works
Self-citationMitochondrial Participation in the Intracellular Ca2+ Network
Babcock, D. F., Herrington, J. B., Goodwin, P. C., Park, Y. B., & Hille, B. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.833 · Cited by 548 · see citing works
Petronilli, V., Costantini, P., Scorrano, L., Colonna, R., Passamonti, S., & Bernardi, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89437-1 · Cited by 531 · see citing works
Self-citationCostantini, P., Chernyak, B. V., Petronilli, V., & Bernardi, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6746 · Cited by 516 · see citing works
Self-citationNicolli, A., Basso, E., Petronilli, V., Wenger, R. M., & Bernardi, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2185 · Cited by 482 · see citing works
Self-citationThe permeability transition pore as a mitochondrial calcium release channel: A critical appraisal
Bernardi, P., & Petronilli, V. (1996) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110643 · Cited by 467 · see citing works
Self-citationThe Ca2+-induced membrane transition in mitochondria
Hunter, D. R., & Haworth, R. A. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90373-4 · Cited by 459 · see citing works
Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabó, I., & Zoratti, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50676-7 · Cited by 453 · see citing works
Self-citationBernardi, P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50355-6 · Cited by 449 · see citing works
Self-citationZamzami, N., Marchetti, P., Castedo, M., Hirsch, T., Susín, S. A., Masse, B., & Kroemer, G. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00280-3 · Cited by 438 · see citing works
Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca 2+
Brustovetsky, N., & Klingenberg, M. (1996) · Biochemistry · doi:10.1021/bi960833v · Cited by 423 · see citing works
Mancini, M., Nicholson, D. W., Roy, S., Thornberry, N. A., Peterson, E. P., Casciola-Rosen, L. A., & Rosen, A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.6.1485 · Cited by 408 · see citing works
The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A
Szabó, I., & Zoratti, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67802-6 · Cited by 371 · see citing works
Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria
Fontaine, E. M., Eriksson, O., Ichas, F., & Bernardi, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12662 · Cited by 347 · see citing works
Self-citationAction of cyclosporine on mitochondrial calcium fluxes
Fournier, N., Ducet, G., & Crevat, A. D. (1987) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762419 · Cited by 340 · see citing works
Beutner, G., Rück, A., Riede, B., Welte, W., & Brdiczka, D. G. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01092-7 · Cited by 337 · see citing works
Mitochondrial Ca2+ homeostasis in intact cells.
Rizzuto, R., Bastianutto, C., Brini, M., Murgia, M., & Pozzan, T. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.5.1183 · Cited by 322 · see citing works
Petronilli, V., Cola, C., Massari, S., Colonna, R., & Bernardi, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80631-0 · Cited by 317 · see citing works
Self-citationMitochondrial Calcium Uptake from Physiological-type Pulses of Calcium
Sparagna, G. C., Gunter, K. K., Sheu, S., & Gunter, T. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27510 · Cited by 309 · see citing works
On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury
Duchen, M. R., McGuinness, O. M., Brown, L. A., & Crompton, M. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.10.1790 · Cited by 294 · see citing works
Pastorino, J. G., Snyder, J. W., Serroni, A., Hoek, J. B., & Farber, J. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85172-4 · Cited by 292 · see citing works
Beatrice, M. C., Palmer, J. W., & Pfeiffer, D. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43551-x · Cited by 291 · see citing works
The mitochondrial megachannel is the permeability transition pore
Szab�, I., & Zoratti, M. (1992) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00769537 · Cited by 274 · see citing works
Transport of calcium by mitochondria
Gunter, K. K., & Gunter, T. E. (1994) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762732 · Cited by 270 · see citing works
Modulation of the mitochondrial megachannel by divalent cations and protons.
Szabó, I., Bernardi, P., & Zoratti, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50677-9 · Cited by 241 · see citing works
Self-citationThe inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria
Petronilli, V., Szabó, I., & Zoratti, M. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81513-3 · Cited by 238 · see citing works
Self-citationChernyak, B. V., & Bernardi, P. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0623w.x · Cited by 233 · see citing works
Self-citationPetronilli, V., Cola, C., & Bernardi, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54034-5 · Cited by 228 · see citing works
Self-citationBroekemeier, K. M., & Pfeiffer, D. R. (1995) · Biochemistry · doi:10.1021/bi00050a027 · Cited by 225 · see citing works
Mitochondrial channel activity studied by patch-clamping mitoplasts
Kinnally, K. W., Campo, M. L., & Tedeschi, H. (1989) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762521 · Cited by 223 · see citing works
Imberti, R., Nieminen, A. L., Herman, B. A., & Lemasters, J. J. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38135-8 · Cited by 219 · see citing works
Petronilli, V., Nicolli, A., Costantini, P., Colonna, R., & Bernardi, P. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90122-8 · Cited by 210 · see citing works
Self-citationThe mitochondrial permeability transition pore may comprise VDAC molecules
Szabó, I., & Zoratti, M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80273-w · Cited by 192 · see citing works
Nicolli, A., Petronilli, V., & Bernardi, P. (1993) · Biochemistry · doi:10.1021/bi00067a039 · Cited by 192 · see citing works
Self-citationPfeiffer, D. R., Schmid, P. C., Beatrice, M. C., & Schmid, H. H. O. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86511-0 · Cited by 189 · see citing works
Mitochondrial function as a determinant of recovery or death in cell response to injury
Lisa, F. D., & Bernardi, P. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_25 · Cited by 184 · see citing works
Self-citationOn the Voltage Dependence of the Mitochondrial Permeability Transition Pore
Scorrano, L., Petronilli, V., & Bernardi, P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12295 · Cited by 178 · see citing works
Self-citationIchas, F., Jouaville, L. S., Sidash, S. S., Mazat, J., & Holmuhamedov, E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00615-6 · Cited by 159 · see citing works
Self-citationMitochondrial function as a determinant of recovery or death in cell response to injury
Lisa, F. D., & Bernardi, P. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006810523586 · Cited by 150 · see citing works
Self-citationLapidus, R. G., & Sokolove, P. M. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1507 · Cited by 129 · see citing works
The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage
Massari, S., & AZZONE, G. F. (1972) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(72)90094-1 · Cited by 106 · see citing works
Self-citationConnern, C. P., & Halestrap, A. P. (1996) · Biochemistry · doi:10.1021/bi9525177 · Cited by 104 · see citing works
Imaging the mitochondrial permeability transition pore in intact cells
Petronilli, V., Miotto, G., Canton, M., Colonna, R., Bernardi, P., & Lisa, F. D. (1998) · BioFactors · doi:10.1002/biof.5520080314 · Cited by 102 · see citing works
Self-citationZottini, M., Barizza, E., Bastianelli, F., et al. (2006) · New Phytologist · doi:10.1111/j.1469-8137.2006.01830.x · Cited by 98 · see citing works
Scherer, B., & Klingenberg, M. (1974) · Biochemistry · doi:10.1021/bi00698a025 · Cited by 95 · see citing works
Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress
Broekemeier, K. M., Carpenter-Deyo, L. J., Reed, D. J., & Pfeiffer, D. R. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80616-o · Cited by 95 · see citing works
Costantini, P., Chernyak, B. V., Petronilli, V., & Bernardi, P. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00256-9 · Cited by 88 · see citing works
Self-citationCostantini, P., Colonna, R., & Bernardi, P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00090-5 · Cited by 88 · see citing works
Self-citationHoek, J. B., Farber, J. L., Thomas, A. P., & Wang, X. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00015-v · Cited by 83 · see citing works
Igbavboa, U., & Pfeiffer, D. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57318-5 · Cited by 81 · see citing works
Immunochemical characterization of the adenine nucleotide translocator
Schultheiß, H., & Klingenberg, M. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08412.x · Cited by 78 · see citing works
cDNA cloning of rat mitochondrial cyclophilin
Woodfield, K.-Y., Price, N. T., & Halestrap, A. P. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(97)00017-1 · Cited by 74 · see citing works
Release of mitochondrial matrix proteins through a Ca2+-requiring, cyclosporin-sensitive pathway
Igbavboa, U., Zwizinski, C. W., & Pfeiffer, D. R. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92644-2 · Cited by 70 · see citing works
Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin
Scorrano, L., Nicolli, A., Basso, E., Petronilli, V., & Bernardi, P. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6111-8_27 · Cited by 67 · see citing works
Self-citationLapidus, R. G., & Sokolove, P. M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81217-a · Cited by 60 · see citing works
Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin
Scorrano, L., Nicolli, A., Basso, E., & Petronilli, V. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006887921810 · Cited by 54 · see citing works
Self-citationEriksson, O., Fontaine, E. M., & Bernardi, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12669 · Cited by 51 · see citing works
Self-citationWeis, M., Kass, G. E. N., & Orrenius, S. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90249-6 · Cited by 37 · see citing works
Effect of Polycation Peptides on Mitochondrial Permeability Transition
Rigobello, M. P., Barzon, E., Marin, O., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2756 · Cited by 37 · see citing works
Eriksson, O., Fontaine, E. M., Petronilli, V., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00549-8 · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ricci, J.-E., Gottlieb, R. A., & Green, D. R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208089 · Cited by 504 · see citing works
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD
Karch, J., Bround, M. J., Khalil, H., Sargent, M. A., Latchman, N., Terada, N., Peixoto, P. M., & Molkentin, J. D. (2019) · Science Advances · doi:10.1126/sciadv.aaw4597 · Cited by 250 · see citing works
Synthesis and transport of creatine in the CNS: Importance for cerebral functions
Béard, E., & Braissant, O. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06935.x · Cited by 192 · see citing works
- Authors
- Bernardi, P., Colonna, R., Costantini, P., Eriksson, O., Fontaine, E., Ichas, F., Massari, S., Nicolli, A., Petronilli, V., & Scorrano, L.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Bernardi, Paolo
- ORCID
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 8
- Issue
- 3-4
- Pages
- 273-281
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W1990764244
- Cited by
- 183
- References
- 78
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 4 · 2012: 10
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- mitochondrial permeability transition, mitochondrial permeability transition pore, cyclosporine, mitochondrial calcium uptake, intracellular calcium homeostasis, cell death, oxidative stress, mitochondrial dysfunction, mitochondrial bioenergetics, cell damage
- MeSH terms
- Mitochondrial ADP, ATP Translocases, Animals, Calcium, Cell Membrane Permeability, Humans, Mitochondria, Cell Death, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
