The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Peptide design for antimicrobial and immunomodulatory applications
Open accessAbstract
The increasing threat of antibiotic resistance in pathogenic bacteria and the dwindling supply of antibiotics available to combat these infections poses a significant threat to human health throughout the world. Antimicrobial peptides (AMPs) have long been touted as the next generation of antibiotics capable of filling the anti‐infective void. Unfortunately, peptide‐based antibiotics have yet to realize their potential as novel pharmaceuticals, in spite of the immense number of known AMP sequences and our improved understanding of their antibacterial mechanism of action. Recently, the immunomodulatory properties of certain AMPs have become appreciated. The ability of small synthetic peptides to protect against infection in vivo has demonstrated that modulation of the innate immune response is an effective strategy to further develop peptides as novel anti‐infectives. This review focuses on the screening methods that have been used to assess novel peptide sequences for their antibacterial and immunomodulatory properties. It will also examine how we have progressed in our ability to identify and optimize peptides with desired biological characteristics and enhanced therapeutic potential. In addition, the current challenges to the development of peptides as anti‐infectives are examined and the strategies being used to overcome these issues are discussed. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 572–583, 2013.
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Cites
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Self-citationSurvival strategies of infectious biofilms
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Cited by
Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions
Raheem, N., & Straus, S. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02866 · Cited by 369
Reassessing the Host Defense Peptide Landscape
Haney, E. F., Straus, S. K., & Hancock, R. E. W. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00043 · Cited by 359
Self-citationGörgüç, A., Gençdağ, E., & Yılmaz, F. M. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109504 · Cited by 312
Romanò, C. L., Scarponi, S., Gallazzi, E., Romanò, D., & Drago, L. (2015) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-015-0294-5 · Cited by 311
Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications
Talapko, J., Meštrović, T., Juzbašić, M., Tomas, M., Erić, S., Horvat Aleksijević, L., Bekić, S., Schwarz, D., Matić, S., Neuberg, M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11101417 · Cited by 281
Metadata
- Authors
- Haney, E. F., & Hancock, R. E. W.
- Venue
- Peptide Science
- Publisher
- Wiley
- Published
- 2013-11
- Volume
- 100
- Issue
- 6
- Pages
- 572-583
- ISSN
- 0006-3525 (ISSN-L)
- OpenAlex
- W1790693342
- Cited by
- 291
- References
- 96
- FWCI
- 13.73
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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