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Cited by 298

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Transcription activator‐like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing

Sun, Ning, Zhao, Huimin·2013·Biotechnology and Bioengineering

Abstract

Transcription activator‐like effector (TALE) nucleases (TALENs) have recently emerged as a revolutionary genome editing tool in many different organisms and cell types. The site‐specific chromosomal double‐strand breaks introduced by TALENs significantly increase the efficiency of genomic modification. The modular nature of the TALE central repeat domains enables researchers to tailor DNA recognition specificity with ease and target essentially any desired DNA sequence. Here, we comprehensively review the development of TALEN technology in terms of scaffold optimization, DNA recognition, and repeat array assembly. In addition, we provide some perspectives on the future development of this technology. Biotechnol. Bioeng. 2013; 110: 1811–1821. © 2013 Wiley Periodicals, Inc.

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Metadata

Authors
Sun, N., & Zhao, H.
Venue
Biotechnology and Bioengineering
Publisher
Wiley
Published
2013-04-07
Volume
110
Issue
7
Pages
1811-1821
ISSN
  • 0006-3592 (ISSN-L)
  • 1097-0290
OpenAlex
W2096791413
Cited by
298
References
12
FWCI
15.47
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Transcription activator‐like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing. https://app.cochat.ai/papers/10.1002/bit.24890
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Sun, N., & Zhao, H. (2013). Transcription activator‐like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.24890

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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