The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Shear stress induced stimulation of mammalian cell metabolism
Open accessAbstract
A flow apparatus has been developed for the study of the metabolic response of anchorage‐dependent cells to a wide range of steady and pulsatile shear stresses under well‐controlled conditions. Human umbilical vein endothelial cell monolayers were subjected to steady shear stresses of up to 24 dynes/cm 2, and the production of prostacyclin was determined. The onset of flow led to a burst in prostacyclin production which decayed to a long term steady state rate (SSR). The SSR of cells exposed to flow was greater than the basal release level, and increased linearly with increasing shear stress. This study demonstrates that shear stress in certain ranges may not be detrimental to mammalian cell metabolism. In fact, throughout the range of shear stresses studied, metabolite production is maximized by maximizing shear stress.
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Cites
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Frangos, J. A., Eskin, S. G., McIntire, L. V., & Ives, C. L. (1985) · Science · doi:10.1126/science.3883488 · Cited by 1,235
Self-citationHow is the level of free arachidonic acid controlled in mammalian cells?
Irvine, R. F. (1982) · Biochemical Journal · doi:10.1042/bj2040003 · Cited by 1,181
The Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress
Levesque, M. J., & Nerem, R. M. (1985) · Journal of Biomechanical Engineering · doi:10.1115/1.3138567 · Cited by 723
Hydrodynamic effects on cells in agitated tissue culture reactors
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Apparatus for subjecting living cells to fluid shear stress
Bussolari, S. R., Dewey, C. F., & Gimbrone, M. A. (1982) · Review of Scientific Instruments · doi:10.1063/1.1136909 · Cited by 177
White Cell Mechanics: Basic Science and Clinical Aspects
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Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Dispersion as an Important Step in the Candida albicans Biofilm Developmental Cycle
Uppuluri, P., Chaturvedi, A. K., Srinivasan, A., Banerjee, M., Ramasubramaniam, A. K., Köhler, J. R., Kadosh, D., & Lopez-Ribot, J. L. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000828 · Cited by 432
Coon, B. G., Baeyens, N., Han, J., Budatha, M., Ross, T. D., Fang, J. S., Yun, S., Thomas, J.-L., & Schwartz, M. A. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201408103 · Cited by 299
Role of hydrodynamic shear in the cultivation of animal, plant and microbial cells
Joshi, J. B., Elias, C. B., & Patole, M. S. (1996) · The Chemical Engineering Journal and the Biochemical Engineering Journal · doi:10.1016/0923-0467(95)03062-x · Cited by 131
Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin
Matsui, N. M., Varki, A., & Embury, S. H. (2002) · Blood · doi:10.1182/blood-2002-02-0626 · Cited by 123
Metadata
- Authors
- Frangos, J. A., McIntire, L. V., & Eskin, S. G.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 1988-10-05
- Volume
- 32
- Issue
- 8
- Pages
- 1053-1060
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W2119892103
- Cited by
- 373
- References
- 9
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
