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Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells
Abstract
Endothelial cell functions, such as arachidonic acid metabolism, may be modulated by membrane stresses induced by blood flow. The production of prostacyclin by primary human endothelial cell cultures subjected to pulsatile and steady flow shear stress was measured. The onset of flow led to a sudden increase in prostacyclin production, which decreased to a steady rate within several minutes. The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steady shear stress and 16 times greater than that of cells in stationary culture.
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Citations
Cited by
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force
Traub, O., & Berk, B. C. (1998) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.18.5.677 · Cited by 1,085
Okano, T., Yamada, N., Sakai, H., & Sakurai, Y. (1993) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820271005 · Cited by 1,020
Molecular basis of the effects of shear stress on vascular endothelial cells
Li, Y.-S. J., Haga, J. H., & Chien, S. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.09.030 · Cited by 904
Metadata
- Authors
- Frangos, J. A., Eskin, S. G., McIntire, L. V., & Ives, C. L.
- Venue
- Science
- Published
- 1985-03-22
- Volume
- 227
- Issue
- 4693
- Pages
- 1477-1479
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999083451
- Cited by
- 1,235
- References
- 0
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frangos, J. A., Eskin, S. G., McIntire, L. V., & Ives, C. L. (1985). Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells. Science. https://doi.org/10.1126/science.3883488
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