The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation
Open accessAbstract
Embryonic stem cells (ESCs) are pluripotent cells capable of differentiating into all somatic and germ cell types. The intrinsic ability of pluripotent cells to generate a vast array of different cells makes ESCs a robust resource for a variety of cell transplantation and tissue engineering applications, however, efficient and controlled means of directing ESC differentiation is essential for the development of regenerative therapies. ESCs are commonly differentiated in vitro by spontaneously self‐assembling in suspension culture into 3D cell aggregates called embryoid bodies (EBs), which mimic many of the hallmarks of early embryonic development, yet the 3D organization and structure of EBs also presents unique challenges to effectively direct the differentiation of the cells. ESC differentiation is strongly influenced by physical and chemical signals comprising the local extracellular microenvironment, thus current methods to engineer EB differentiation have focused primarily on spatially controlling EB size, adding soluble factors to the media, or culturing EBs on or within natural or synthetic extracellular matrices. Although most such strategies aim to influence differentiation from the exterior of EBs, engineering the microenvironment directly within EBs enables new opportunities to efficiently direct the fate of the cells by locally controlling the presentation of morphogenic cues. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009
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Advances in 3D cell culture technologies enabling tissue‐like structures to be created in vitro
Knight, E., & Przyborski, S. (2015) · Journal of Anatomy · doi:10.1111/joa.12257 · Cited by 530
Rizvi, A. H., Camara, P. G., Kandror, E. K., Roberts, T. J., Schieren, I., Maniatis, T., & Rabadan, R. (2017) · Nature Biotechnology · doi:10.1038/nbt.3854 · Cited by 248
Bioengineering approaches to guide stem cell-based organogenesis
Gjorevski, N., Ranga, A., & Lutolf, M. P. (2014) · Development · doi:10.1242/dev.101048 · Cited by 137
Carpenedo, R. L., Bratt-Leal, A. M., Marklein, R. A., Seaman, S. A., Bowen, N. J., McDonald, J. F., & McDevitt, T. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.007 · Cited by 133
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Metadata
- Authors
- Bratt‐Leal, A. M., Carpenedo, R. L., & McDevitt, T. C.
- Venue
- Biotechnology Progress
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 25
- Issue
- 1
- Pages
- 43-51
- ISSN
- 1520-6033 (ISSN-L)
- 8756-7938
- OpenAlex
- W2002828554
- Cited by
- 271
- References
- 92
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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