The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Targeting Mitochondria with Organelle‐Specific Compounds: Strategies and Applications
Abstract
Mitochondria are the energy factories of the cell and also serve as a checkpoint regulating programmed cell death. Not surprisingly, dysfunctional mitochondria are implicated in a variety of diseases ranging from metabolic disorders to cancer. Treatment of these diseases through the delivery of targeted drugs, however, is impeded by the difficulty of penetrating the membranes that define this organelle. The properties of this barrier serve as a major obstacle to drug delivery and a lack of effective transporters has hindered the advancement of mitochondrial medicine. Recently, however, synthetic transporters that show promise for the mito‐specific delivery of bioactive cargos have begun to emerge. This review summarizes the most exciting of these developments and discusses their applications.
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Cites
Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy
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Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
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Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
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Mitochondria, oxygen free radicals, disease and ageing
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Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
Robinson, K. M., Janes, M. S., Pehar, M., Monette, J. S., Ross, M. F., Hagen, T. M., Murphy, M. P., & Beckman, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601945103 · Cited by 777
Delivery of bioactive molecules to mitochondria in vivo
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Selective targeting of an antioxidant to mitochondria
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Selective targeting of bioactive compounds to mitochondria
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Cited by
Strategies in the design of nanoparticles for therapeutic applications
Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651
Targeting mitochondria for cancer therapy
Fulda, S., Galluzzi, L., & Kroemer, G. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3137 · Cited by 1,629
Small-Molecule Two-Photon Probes for Bioimaging Applications
Kim, H. M., & Cho, B. R. (2015) · Chemical Reviews · doi:10.1021/cr5004425 · Cited by 1,047
Zeng, L., Gupta, P., Chen, Y., Wang, E., Ji, L., Chao, H., & Chen, Z.-S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00195a · Cited by 1,017
Smith, R. A. J., Hartley, R. C., Cochemé, H. M., & Murphy, M. P. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.010 · Cited by 499
Metadata
- Authors
- Yousif, L. F., Stewart, K. M., & Kelley, S. O.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2009-08-12
- Volume
- 10
- Issue
- 12
- Pages
- 1939-1950
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W2167370588
- Cited by
- 330
- References
- 12
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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