The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends
Abstract
The use of biosensors in point‐of‐care (POC) testing devices has attracted considerable attention in the past few years, mainly because of their high specificity, portability, and relatively low cost. Coupling these devices with miniaturized electrochemical transducers has shown great potential toward simple, rapid, and cost‐effective analysis that can be performed in the field, especially for healthcare, environmental monitoring, and food quality control. For this reason, the number of publications in this field has grown exponentially over the past decade, making it a trending topic in current research. Although great improvement has been achieved in the field of electrochemical biosensing, there are still some challenges to overcome, especially concerning the improvement of sensing materials and miniaturization. In this Review, we summarize some of the most recent advances achieved in POC electrochemical biosensor applications, focusing on new materials and modifiers for biorecognition developed to improve sensitivity, specificity, stability, and response time.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Electric Field Effect in Atomically Thin Carbon Films
Novoselov, K. S., Geim, A. K., Morozov, S. V., Jiang, D., Zhang, Y., Dubonos, S. V., Grigorieva, I. V., & Firsov, A. A. (2004) · Science · doi:10.1126/science.1102896 · Cited by 66,834
In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,812
ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY
Clark, L. C., & Lyons, C. (1962) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1962.tb13623.x · Cited by 3,945
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
Graphene Based Electrochemical Sensors and Biosensors: A Review
Shao, Y., Wang, J., Wu, H., Liu, J., Aksay, I. A., & Lin, Y. (2010) · Electroanalysis · doi:10.1002/elan.200900571 · Cited by 3,124
The present and future role of microfluidics in biomedical research
Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995
Georgakilas, V., Tiwari, J. N., Kemp, K. C., Perman, J. A., Bourlinos, A. B., Kim, K. S., & Zboril, R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00620 · Cited by 2,494
Ronkainen, N. J., Halsall, H. B., & Heineman, W. R. (2010) · Chemical Society Reviews · doi:10.1039/b714449k · Cited by 1,945
Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures
Zhu, C., Yang, G., Li, H., Du, D., & Lin, Y. (2015) · Analytical Chemistry · doi:10.1021/ac5039863 · Cited by 1,741
Functional π-Gelators and Their Applications
Babu, S. S., Praveen, V. K., & Ajayaghosh, A. (2014) · Chemical Reviews · doi:10.1021/cr400195e · Cited by 1,725
Electrochemical Glucose Sensors and Their Applications in Diabetes Management
Heller, A., & Feldman, B. (2008) · Chemical Reviews · doi:10.1021/cr068069y · Cited by 1,707
New developments in liposomal drug delivery
Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600
Electrochemical biosensors: Towards point-of-care cancer diagnostics
Wang, J. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.10.027 · Cited by 1,454
Application of Nanoparticles in Electrochemical Sensors and Biosensors
Luo, X., Morrin, A., Killard, A. J., & Smyth, M. R. (2006) · Electroanalysis · doi:10.1002/elan.200503415 · Cited by 1,318
Point of Care Diagnostics: Status and Future
Gubala, V., Harris, L. F., Ricco, A. J., Tan, M. X., & Williams, D. E. (2012) · Analytical Chemistry · doi:10.1021/ac2030199 · Cited by 1,194
An overview of foodborne pathogen detection: In the perspective of biosensors
Velusamy, V., Arshak, K., Korostynska, O., Oliwa, K., & Adley, C. (2010) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.12.004 · Cited by 1,185
Point-of-Care Diagnostics for Global Health
Yager, P., Domingo, G. J., & Gerdes, J. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160524 · Cited by 1,076
Nanomaterial-based electrochemical biosensors
Wang, J. (2005) · The Analyst · doi:10.1039/b414248a · Cited by 881
Nanomaterial-based Electrochemical Biosensors
Şensoy, K. G., Akpınar, F., & Muti, M. (2024) · Current Nanoscience · doi:10.2174/1573413718666220819143711 · Cited by 701
Tattoo-Based Noninvasive Glucose Monitoring: A Proof-of-Concept Study
Bandodkar, A. J., Jia, W., Yardımcı, C., Wang, X., Ramirez, J., & Wang, J. (2015) · Analytical Chemistry · doi:10.1021/ac504300n · Cited by 700
Wearable Electrochemical Sensors and Biosensors: A Review
Windmiller, J. R., & Wang, J. (2013) · Electroanalysis · doi:10.1002/elan.201200349 · Cited by 696
Biosensors and bioelectronics on smartphone for portable biochemical detection
Zhang, D., & Liu, Q. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.08.037 · Cited by 647
Recent developments in the field of screen-printed electrodes and their related applications
Renedo, O. D., Alonso-Lomillo, M. A., & Martínez, M. J. A. (2007) · Talanta · doi:10.1016/j.talanta.2007.03.050 · Cited by 647
Review of the use of biosensors as analytical tools in the food and drink industries
Mello, L. D., & Kubota, L. T. (2002) · Food Chemistry · doi:10.1016/s0308-8146(02)00104-8 · Cited by 584
Self-citationEngineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules
Tiwari, J. N., Vij, V., Kemp, K. C., & Kim, K. S. (2016) · ACS Nano · doi:10.1021/acsnano.5b05690 · Cited by 559
Screen-printed electrodes for biosensing: a review (2008–2013)
Taleat, Z., Khoshroo, A., & Mazloum-Ardakani, M. (2014) · Microchimica Acta · doi:10.1007/s00604-014-1181-1 · Cited by 542
A smartphone dongle for diagnosis of infectious diseases at the point of care
Laksanasopin, T., Guo, T. W., Nayak, S., Sridhara, A. A., Xie, S., Olowookere, O. O., Cadinu, P., Meng, F., Chee, N. H., Kim, J., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa0056 · Cited by 425
Bahadır, E. B., & Sezgintürk, M. K. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.03.011 · Cited by 424
Kumar, S., Ahlawat, W., Kumar, R., & Dilbaghi, N. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.03.062 · Cited by 412
Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials
Song, Y., Luo, Y., Zhu, C., Li, H., Du, D., & Lin, Y. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.07.002 · Cited by 390
Point of care testing: The impact of nanotechnology
Syedmoradi, L., Daneshpour, M., Alvandipour, M., Gomez, F. A., Hajghassem, H., & Omidfar, K. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.084 · Cited by 367
Nanomaterials for bio-functionalized electrodes: recent trends
Walcarius, A., Minteer, S. D., Wang, J., Lin, Y., & Merkoçi, A. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20881h · Cited by 366
Biosensors as innovative tools for the detection of food borne pathogens
Arora, P., Sindhu, A., Dilbaghi, N., & Chaudhury, A. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.06.002 · Cited by 350
Surface immobilization methods for aptamer diagnostic applications
Balamurugan, S., Obubuafo, A., Soper, S. A., & Spivak, D. A. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-007-1587-2 · Cited by 312
Recent advances in biosensor techniques for environmental monitoring
Rogers, K. R. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2005.12.067 · Cited by 306
Growth of Metal–Metal Oxide Nanostructures on Freestanding Graphene Paper for Flexible Biosensors
Xiao, F., Li, Y., Zan, X., Liao, K., Xu, R., & Duan, H. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201200191 · Cited by 273
Assembly of Graphene Oxide–Enzyme Conjugates through Hydrophobic Interaction
Zhang, Y., Zhang, J., Huang, X., Zhou, X., Wu, H., & Guo, S. (2012) · Small · doi:10.1002/smll.201101695 · Cited by 268
Chaiyo, S., Mehmeti, E., Žagar, K., Siangproh, W., Chailapakul, O., & Kalcher, K. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.03.026 · Cited by 260
Paper-based chemical and biological sensors: Engineering aspects
Ahmed, S., Bui, M.-P. N., & Abbas, A. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.09.038 · Cited by 249
Kong, F.-Y., Gu, S.-X., Li, W.-W., Chen, T.-T., Xu, Q., & Wang, W. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.12.067 · Cited by 217
New biorecognition molecules in biosensors for the detection of toxins
Bazin, I., Tria, S. A., Hayat, A., & Marty, J.-L. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.06.083 · Cited by 195
A Paper-Based “Pop-up” Electrochemical Device for Analysis of Beta-Hydroxybutyrate
Wang, C.-C., Hennek, J. W., Ainla, A., Kumar, A. A., Lan, W.-J., Im, J., Smith, B. S., Zhao, M., & Whitesides, G. M. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00568 · Cited by 180
Reduced graphene oxide modified smart conducting paper for cancer biosensor
Kumar, S., Kumar, S., Srivastava, S., Yadav, B. K., Lee, S. H., Sharma, J. G., Doval, D. C., & Malhotra, B. D. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.05.040 · Cited by 174
Chen, X., Wang, Y., Zhang, Y., Chen, Z., Liu, Y., Li, Z., & Li, J. (2014) · Analytical Chemistry · doi:10.1021/ac404070m · Cited by 171
Tomalia, D. A., Hall, M., & Hedstrand, D. M. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00239a068 · Cited by 158
Recent advances in low‐cost microfluidic platforms for diagnostic applications
Coltro, W. K. T., Cheng, C., Carrilho, E., & de Jesus, D. P. (2014) · Electrophoresis · doi:10.1002/elps.201400006 · Cited by 149
Liu, G., Qi, M., Zhang, Y., Cao, C., & Goldys, E. M. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.12.023 · Cited by 146
A label-free and portable graphene FET aptasensor for children blood lead detection
Wang, C., Cui, X., Li, Y., Li, H., Huang, L., Bi, J., Luo, J. H., Ma, L. Q., Zhou, W., Cao, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep21711 · Cited by 116
Electrochemical aptamer-based biosensors as potential tools for clinical diagnostics
Jarczewska, M., Górski, Ł., & Malinowska, E. (2016) · Analytical Methods · doi:10.1039/c6ay00499g · Cited by 113
Lan, T., Zhang, J., & Lu, Y. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.03.002 · Cited by 111
Gold nanoparticles mediated label-free capacitance detection of cardiac troponin I
Bhalla, V., Carrara, S., Sharma, P., Nangia, Y., & Suri, C. R. (2011) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2011.11.029 · Cited by 108
Sun, A. C., Yao, C., Venkatesh and, G., & Hall, D. A. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.05.010 · Cited by 107
Abnous, K., Danesh, N. M., Alibolandi, M., Ramezani, M., Taghdisi, S. M., & Emrani, A. S. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.08.100 · Cited by 107
Bendable Electro-chemical Lactate Sensor Printed with Silver Nano-particles
Abrar, M. A., Dong, Y., Lee, P. K., & Kim, W. S. (2016) · Scientific Reports · doi:10.1038/srep30565 · Cited by 105
Voltammetric aptasensors for protein disease biomarkers detection: A review
Meirinho, S. G., Dias, L. G., Peres, A. M., & Rodrigues, L. R. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.05.006 · Cited by 104
Microfluidic Paper-Based Devices for Bioanalytical Applications
Santhiago, M., Nery, E. W., dos Santos, G. P., & Kubota, L. T. (2013) · Bioanalysis · doi:10.4155/bio.13.296 · Cited by 99
Self-citationAlwarappan, S., Boyapalle, S., Kumar, A., Li, C.-Z., & Mohapatra, S. S. (2012) · The Journal of Physical Chemistry C · doi:10.1021/jp211201b · Cited by 99
Supramolecular Self-Assembly Induced Graphene Oxide Based Hydrogels and Organogels
Cheng, Q.-Y., Zhou, D., Gao, Y., Chen, Q., Zhang, Z., & Han, B. (2012) · Langmuir · doi:10.1021/la204558f · Cited by 96
Biosensors in clinical chemistry: An overview
Ramasamy, R., Murugaiyan, S., Gopal, N., & KuzhandaiVelu, V. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.125848 · Cited by 89
Li, F., Peng, J., Zheng, Q., Guo, X. Y., Tang, H., & Yao, S. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00093 · Cited by 89
Development of a disposable biosensor for lactate monitoring in saliva
Πετρόπουλος, Κ., Piermarini, S., Bernardini, S., Palleschi, G., & Moscone, D. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.06.068 · Cited by 79
Biosensors based on one-dimensional nanostructures
Feigel, I. M., Vedala, H., & Star, A. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm10521c · Cited by 78
Development of a wearable electrochemical sensor for voltammetric determination of chloride ions
Bujes-Garrido, J., & Arcos‐Martínez, M. J. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.08.119 · Cited by 78
He, W., Sun, Y., Xi, J., Abdurhman, A. A. M., Ren, J., & Duan, H. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.11.019 · Cited by 77
Kim, S. G., Lee, J. S., Jun, J., Shin, D. H., & Jang, J. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b11159 · Cited by 75
Ebrahimi, M. S., Voß, Y., & Schönherr, H. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b05746 · Cited by 72
Highly Stable Positively Charged Dendron-Encapsulated Gold Nanoparticles
Cho, T. J., MacCuspie, R. I., Gigault, J., Gorham, J. M., Elliott, J. T., & Hackley, V. A. (2014) · Langmuir · doi:10.1021/la5002013 · Cited by 64
Novel reagentless glucose biosensor based on ferrocene cored asymmetric PAMAM dendrimers
Şenel, M., Nergiz, C., & Çevik, E. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.10.072 · Cited by 62
Bahrami, S., Abbasi, A. R., Roushani, M., et al. (2016) · Talanta · doi:10.1016/j.talanta.2016.05.060 · Cited by 61
Photocatalysis-Induced Renewable Field-Effect Transistor for Protein Detection
Zhang, C., Xu, J.-Q., Li, Y., Huang, L., Pang, D., Ning, Y., Huang, W., Zhang, Z., & Zhang, G. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00374 · Cited by 58
Brief Timelapse on Dendrimer Chemistry: Advances, Limitations, and Expectations
Ornelas, C. (2015) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201500393 · Cited by 57
Souto, D. E. P., Fonseca, A. M., Barragan, J. T. C., Luz, R. D. C. S., de Andrade, H. M., Damos, F. S., & Kubota, L. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.03.034 · Cited by 52
Self-citationHan, S. W., & Koh, W. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04867 · Cited by 50
Sensitive point-of-care monitoring of HIV related DNA sequences with a personal glucometer
Xu, J., Jiang, B., Xie, J., Xiang, Y., Yuan, R., & Chai, Y. (2012) · Chemical Communications · doi:10.1039/c2cc35941c · Cited by 44
Karadag, M., Geyik, C., Demirkol, D. O., ERTAŞ, F. N., & Tımur, S. (2012) · Materials Science and Engineering C · doi:10.1016/j.msec.2012.10.008 · Cited by 44
Li, X., Takeda, K., Yuba, E., Harada, A., & Kono, K. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00132j · Cited by 43
Screen-printed back-to-back electroanalytical sensors
Metters, J. P., Randviir, E. P., & Banks, C. E. (2014) · The Analyst · doi:10.1039/c4an01501k · Cited by 40
An overview of transducers as platform for the rapid detection of foodborne pathogens
Arora, P., Sindhu, A., Kaur, H., Dilbaghi, N., & Chaudhury, A. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4692-5 · Cited by 34
Thangamuthu, M., Santschi, C., & Martin, O. J. F. (2015) · The Analyst · doi:10.1039/c5an00752f · Cited by 33
Krepker, M. A., & Segal, E. (2013) · Analytical Chemistry · doi:10.1021/ac4011815 · Cited by 32
Öberg, K., Ropponen, J., Kelly, J., Löwenhielm, P., Berglin, M., & Malkoch, M. (2012) · Langmuir · doi:10.1021/la3041314 · Cited by 27
A physical mechanism of cancer heterogeneity
Chen, C., & Wang, J. (2016) · Scientific Reports · doi:10.1038/srep20679 · Cited by 26
Song, Y., Liu, H., Wang, Y., & Wang, L. (2013) · Analytical Methods · doi:10.1039/c3ay40399h · Cited by 24
Li, J., Wu, J., Cui, L., Liu, M., Yan, F., & Ju, H. (2015) · The Analyst · doi:10.1039/c5an01946j · Cited by 22
Poorahong, S., Santhosh, P., Valdés‐Ramírez, G., Tseng, T.-F., Wong, J. I., Kanatharana, P., Thavarungkul, P., & Wang, J. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.01.026 · Cited by 22
Carvalhal, R. F., Machado, D. S., Mendes, R. K., Almeida, A. L. J., Moreira, N. H., Piazzetta, M. H. O., Gobbi, Â. L., & Kubota, L. T. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.02.026 · Cited by 13
Self-citationChen, J., Wu, W., & Zeng, L. (2014) · Analytical Methods · doi:10.1039/c4ay00323c · Cited by 12
(2000) · doi:10.1002/1439-7641(20000804)1:1<18::aid-cphc18>3.0.co;2-l
Metadata
- Authors
- da Silva, E. T. S. G., Souto, D. E. P., Barragan, J. T. C., de F. Giarola, J., de Moraes, A. C. M., & Kubota, L. T.
- Venue
- ChemElectroChem
- Publisher
- Wiley
- Published
- 2017-02-08
- Volume
- 4
- Issue
- 4
- Pages
- 778-794
- ISSN
- 2196-0216 (ISSN-L)
- OpenAlex
- W2569176550
- Cited by
- 373
- References
- 88
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
