The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A Continuous‐Flow Process for the Synthesis of Artemisinin
Abstract
Isolation of the most effective antimalarial drug, artemisinin, from the plant sweet wormwood, does not yield sufficient quantities to provide the more than 300 million treatments needed each year. The high prices for the drug are a consequence of the unreliable and often insufficient supply of artemisinin. Large quantities of ineffective fake drugs find a market in Africa. Semisynthesis of artemisinin from inactive biological precursors, either dihydroartemisinic acid (DHAA) or artemisinic acid, offers a potentially attractive route to increase artemisinin production. Conversion of the plant waste product, DHAA, into artemisinin requires use of photochemically generated singlet oxygen at large scale. We met this challenge by developing a one‐pot photochemical continuous‐flow process for the semisynthesis of artemisinin from DHAA that yields 65 % product. Careful optimization resulted in a process characterized by short residence times. A method to extract DHAA from the mother liquor accumulated during commercial artemisinin extractions, a material that is currently discarded as waste, is also reported. The synthetic continuous‐flow process described here is an effective means to supplement the limited availability of artemisinin and ensure increased supplies of the drug for those in need.
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Cites
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Schmid, G., & Hofheinz, W. (1983) · Journal of the American Chemical Society · doi:10.1021/ja00341a054 · Cited by 329
Wallaart, T. E., Pras*, N., Beekman, A., & Quax, W. J. (2000) · Planta Medica · doi:10.1055/s-2000-11115 · Cited by 281
Haynes, R. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776743129 · Cited by 224
Haynes, R. K., & Vonwiller, S. C. (1997) · Accounts of Chemical Research · doi:10.1021/ar950058w · Cited by 220
Total synthesis of arteannuin and deoxyarteannuin
Xing-Xiang, X., Jie, Z., Da-Zhong, H., & Wei-Shan, Z. (1986) · Tetrahedron · doi:10.1016/s0040-4020(01)87487-1 · Cited by 181
Delabays, N., Simonnet, X., & Gaudin, M. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013371635 · Cited by 178
A simple conversion of artemisinic acid into artemisinin
Roth, R. J., & Acton, N. (1989) · Journal of Natural Products · doi:10.1021/np50065a050 · Cited by 136
Covello, P. S. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.10.001 · Cited by 127
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The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Self-citationCambié, D., Bottecchia, C., Straathof, N. J. W., Hessel, V., & Noël, T. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00707 · Cited by 1,502
Buglioni, L., Raymenants, F., Slattery, A., Zondag, S. D. A., & Noël, T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00332 · Cited by 781
Using Singlet Oxygen to Synthesize Natural Products and Drugs
Ghogare, A. A., & Greer, A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00726 · Cited by 719
Industrial natural product chemistry for drug discovery and development
Bauer, A., & Brönstrup, M. (2014) · Nat. Prod. Rep. · doi:10.1039/c3np70058e · Cited by 255
Metadata
- Authors
- Kopetzki, D., Lévesque, F., & Seeberger, P. H.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2013-03-20
- Volume
- 19
- Issue
- 17
- Pages
- 5450-5456
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2166384326
- Cited by
- 218
- References
- 16
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- closed
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