A simple conversion of artemisinic acid into artemisinin
Abstract
Artemisinic acid [1] has been converted into artemisinin [3] in 2 steps via reduction of the exocyclic methylene group and photooxidation of the resulting dihydroartemisinic acid [2].
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The semi-synthesis of artemisinin from microbially-produced artemisinic acid requires two further chemical steps: reduction of the exocyclic double bond and photo-sensitized oxidation of the endocyclic double bond to produce the 1,2,4-trioxane ring.
“The semi-synthesis of artemisinin (495) from microbially-produced artemisinic acid (473) then requires two further chemical steps: reduction of the exocyclic double bond; and photo-sensitized oxidation of the endocyclic double bond to produce the 1,2,4-trioxane ring in (495) [156,237].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [156]
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- Authors
- Roth, R. J., & Acton, N.
- Affiliations
- George Mason University (US)
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1989-09
- Volume
- 52
- Issue
- 5
- Pages
- 1183-1185
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W4243183814
- Cited by
- 136
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 11 · 2013: 6 · 2012: 5
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- artemisinic acid, artemisinin, total synthesis, photooxidation, dihydroartemisinic acid, sesquiterpene lactones
- MeSH terms
- Antimalarials, Drugs, Chinese Herbal, Oxidation-Reduction, Sesquiterpenes, Temperature, Molecular Structure, Artemisinins
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