The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mechanical Downsizing of a Gadolinium(III)‐based Metal–Organic Framework for Anticancer Drug Delivery
Abstract
A Gd III‐based porous metal–organic framework (MOF), Gd‐pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4‐bis(5‐carboxy‐1H‐benzimidazole‐2‐yl)benzene)), resulting in a three‐dimensional interpenetrated structure with a one‐dimensional open channel (1.9×1.2 nm) filled with hydrogen‐bonded water assemblies. Gd‐pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic‐solvent and mild acid and base stability with retention of crystallinity. Gd‐pDBI was transformed to the nanoscale regime (ca. 140 nm) by mechanical grinding to yield MG‐Gd‐pDBI with excellent water dispersibility (>90 min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG‐Gd‐pDBI revealed its low blood toxicity and highest drug loading (12 wt %) of anticancer drug doxorubicin in MOFs reported to date with pH‐responsive cancer‐cell‐specific drug release.
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Cites
Nanocarriers as an emerging platform for cancer therapy
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Metal-organic framework materials as catalysts
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BioMOFs: Metal–Organic Frameworks for Biological and Medical Applications
McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000048 · Cited by 1,256
Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Metadata
- Authors
- Kundu, T., Mitra, S., Patra, P., Goswami, A., Díaz Díaz, D., & Banerjee, R.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2014-07-17
- Volume
- 20
- Issue
- 33
- Pages
- 10514-10518
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2096988215
- Cited by
- 251
- References
- 4
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kundu, T., Mitra, S., Patra, P., Goswami, A., Díaz Díaz, D., & Banerjee, R. (2014). Mechanical Downsizing of a Gadolinium(III)‐based Metal–Organic Framework for Anticancer Drug Delivery. Chemistry – A European Journal. https://doi.org/10.1002/chem.201402244
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