The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Meta-analysis of vitamin D deficiency and risk of atrial fibrillation
Abstract
Background: There are accumulating studies investigating the association between vitamin D status and the risk of atrial fibrillation (AF). However, the results in these studies were inconsistent in regard to the role of vitamin D deficiency in predicting the development of AF. Hypothesis: Vitamin D deficiency is associated increased risk of AF. Methods: Using PubMed and Embase databases, we searched for records published before March 2016. Additionally, a manual search was conducted using all review articles on this topic. Of the 587 initially identified records, 8 studies with a total of 27 307 patients were finally analyzed. Results: In the categorical variable analysis, vitamin D deficiency was associated with the occurrence of AF (odds ratio: 1.31, 95% confidence interval: 1.06‐1.62, P = 0.01). In the continuous variable analysis, higher vitamin D levels appear to protect against the development of AF (odds ratio: 0.92, 95% confidence interval: 0.87‐0.97, P = 0.002). However, the association is weak on the pooled analysis of prospective cohort studies focused on new‐onset AF (P = 0.07 and 0.04), whereas the pooled analysis of case–control studies mainly assessing for chronic AF strongly support such an association (both P < 0.0001). Conclusions: Vitamin D deficiency modestly increases the risk of AF. Further studies are needed to determine the if there is a direct causal relationship between vitamin D levels and AF and whether vitamin D supplements will prevent new‐onset AF.
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“Epidemiological studies have confirmed an association between low serum 25-hydroxyvitamin D [25(OH)D] concentrations and CV diseases, including coronary artery disease, hypertension, and arrhythmias (6–8).”
From The decline of vitamin D in adolescent athletes: insights from a one-year follow-up and its association with electrocardiographic changes (2025) · cites this paper as [7]
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von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020
Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study
Chugh, S. S., Havmoeller, R., Narayanan, K., Singh, D., Rienstra, M., Benjamin, E. J., Gillum, R. F., Kim, Y.-H., McAnulty, J. H., Zheng, Z.-J., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.005119 · Cited by 4,506
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Cited by
Albert, C. M., Cook, N. R., Pester, J., Moorthy, M. V., Ridge, C., Danik, J. S., Gencer, B., Siddiqi, H. K., Ng, C., Gibson, H., et al. (2021) · JAMA · doi:10.1001/jama.2021.1489 · Cited by 133
Self-citationRamadan, M. M., Jaber, A. A., Aladwani, A. J., Alayyaf, A. E., Sayed-Noor, A. S., Ghanem, H. B., El-Sherbiny, M., Ebrahim, H. A., Ahmed, M. M., & Elsherbini, D. M. A. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1731919 · Cited by 1
Metadata
- Authors
- Zhang, Z., Yang, Y., Ng, C. Y., Wang, D., Wang, J., Li, G., & Liu, T.
- Affiliations
- Tianjin Key Laboratory of Ionic‐Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin People's Republic of China
- Cardiac Arrhythmia Service, Massachusetts General Hospital Boston, Massachusetts
- Venue
- Clinical Cardiology
- Publisher
- Wiley
- Published
- 2016-08-24
- Volume
- 39
- Issue
- 9
- Pages
- 537-543
- ISSN
- 0160-9289
- 1932-8737
- Cited by
- 43
- References
- 5
- Language
- en
- Funders
- National Natural Science Foundation of China (81270245, 81570298)
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