Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
Open accessAbstract
In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (1997-2001; n = 1,381; mean age = 59 years; 52% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p < 0.01). Percentage of undercarboxylated osteocalcin, a functional measure of vitamin K status, was not associated with overall inflammation but was associated with C-reactive protein (p < 0.01). Although plasma 25-hydroxyvitamin D was inversely associated with urinary isoprostane concentration, an indicator of oxidative stress (p < 0.01), overall associations between vitamin D status and inflammation were inconsistent. The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation.
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In 43 subjects at high risk of IHD, a 6-month individualised supervised exercise programme produced a non-significant 35% reduction in CRP concentration.
“After a 6-month individualised, supervised exercise programme for forty-three subjects at high risk of IHD, a 35 %, albeit non-significant, reduction in CRP concentration was observed.The subjects exercised for a mean of 2•5 (range 0•3-7•4) h/week (233) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [233]
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Self-citation
- Authors
- Shea, M. K., Booth, S. L., Massaro, J. M., Jacques, P. F., D'Agostino, R. B., Dawson-Hughes, B., Ordovas, J. M., O'Donnell, C. J., Kathiresan, S., Keaney, J. F., Vasan, R. S., & Benjamin, E. J.
- Affiliations
- Tufts University (US)
- Boston University (US)
- Harvard University (US)
- National Heart, Lung, and Blood Institute (US)
- ORCID
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-27
- Volume
- 167
- Issue
- 3
- Pages
- 313-320
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC3151653
- OpenAlex
- W1997715561
- Cited by
- 316
- References
- 53
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 9 · 2023: 17 · 2022: 23 · 2021: 15 · 2020: 21 · 2019: 23 · 2018: 16 · 2017: 18 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 21 · 2012: 21
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Agriculture
- Deutsches Krebsforschungszentrum
- National Institutes of Health (n01hc038038-022, n01hc25195-41-0-1)
- Agricultural Research Service
- National Institute on Aging (AG 14759, R01AG028321, AG-028321, R01AG014759)
- National Heart, Lung, and Blood Institute (HL-076784, R01HL058090, T32HL69772-0141, HC25195, HL-58090, 2K24 HL 04334, K24HL004334, N01-HC-38038, N01-HC-025195, R01HL064753, HL064753, T32HL069772, R01HL076784)
- National Center for Research Resources (M01RR001066, M01-RR01066)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin K, vitamin D, inflammation, inflammatory markers, vitamin K1, undercarboxylated osteocalcin, C-reactive protein, 25-hydroxyvitamin D, isoprostanes, oxidative stress
- MeSH terms
- Adult, Aged, Aged, 80 and over, Coronary Disease, Cross-Sectional Studies, Female, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Risk Factors, Vitamin D, Vitamin K, Vitamins, Biomarkers, Survival Analysis, Cytokines, Inflammation Mediators
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