The prevalence and management of angina among patients with chronic coronary artery disease across US outpatient cardiology practices: insights from the Angina Prevalence and Provider Evaluation of Angina Relief ( APPEAR ) study
Open accessAbstract
Although eliminating angina is a primary goal in treating patients with chronic coronary artery disease (CAD), few contemporary data quantify prevalence and severity of angina across US cardiology practices. The authors hypothesized that angina among outpatients with CAD managed by US cardiologists is low and its prevalence varies by site. Among 25 US outpatient cardiology clinics enrolled in the American College of Cardiology Practice Innovation and Clinical Excellence (PINNACLE) registry, we prospectively recruited a consecutive sample of patients with chronic CAD over a 1‐ to 2‐week period at each site between April 2013 and July 2015, irrespective of the reason for their appointment. Eligible patients had documented history of CAD (prior acute coronary syndrome, prior coronary revascularization procedure, or diagnosis of stable angina) and ≥1 prior office visit at the practice site. Angina was assessed directly from patients using the Seattle Angina Questionnaire Angina Frequency score. Among 1257 patients from 25 sites, 7.6% (n = 96) reported daily/weekly, 25.1% (n = 315) monthly, and 67.3% (n = 846) no angina. The proportion of patients with daily/weekly angina at each site ranged from 2.0% to 24.0%, but just over half (56.3%) were on ≥2 antianginal medications, with wide variability across sites (0%–100%). One‐third of outpatients with chronic CAD managed by cardiologists report having angina in the prior month, and 7.6% have frequent symptoms. Among those with frequent angina, just over half were on ≥2 antianginal medications, with wide variability across sites. These findings suggest an opportunity to improve symptom control.
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About one-third of patients with stable coronary artery disease report chronic angina.
“about one-third of patients with stable CAD report chronic angina”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [233]
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Self-citation
- Authors
- Kureshi, F., Shafiq, A., Arnold, S. V., Gosch, K., Breeding, T., Kumar, A. S., Jones, P. G., & Spertus, J. A.
- Affiliations
- Saint Luke's Hospital (US)
- University of Missouri–Kansas City (US)
- Corresponding author
- Kureshi, Faraz
- Venue
- Clinical Cardiology
- Publisher
- Wiley
- Published
- 2016-11-07
- Volume
- 40
- Issue
- 1
- Pages
- 6-10
- ISSN
- 0160-9289 (ISSN-L)
- 1932-8737
- PMC
- PMC5300688
- OpenAlex
- W2550573619
- Cited by
- 40
- References
- 28
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 1
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Cardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute of the National Institutes of Health (T32HL110837)
- Gilead Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- angina pectoris, stable coronary artery disease, symptom management, regional variation, Seattle Angina Questionnaire, PINNACLE registry, stable angina
- MeSH terms
- Aged, Angina Pectoris, Chronic Disease, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Male, Outpatients, Prospective Studies, Registries, United States, Prevalence, Disease Management
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