The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Further Evidence of the Anti‐inflammatory Effects of Silver Nanoparticles
Abstract
The production of pure silver in nanoparticle size has opened new dimensions in the clinical use of this precious metal. We and others have demonstrated previously that silver nanoparticles (nAg) possess efficient antimicrobial activity. Herein we show they may also have significant anti‐inflammatory effects in a postoperative peritoneal adhesion model. This finding provides further insight into the biological actions of nAg as well as a potentially novel therapy for peritoneal adhesions in clinical surgery.magnified image With the advent of nanoscience, pure silver can now be made into nanometer‐sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti‐inflammatory properties. Herein we further confirm the anti‐inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti‐inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions.
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Cites
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
LPS induction of gene expression in human monocytes
Guha, M., & Mackman, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00149-2 · Cited by 2,304
Nanosilver: A nanoproduct in medical application
Chen, X., & Schluesener, H. J. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2007.10.004 · Cited by 1,888
Carlson, C., Hussain, S. M., Schrand, A. M., K. Braydich-Stolle, L., Hess, K. L., Jones, R. L., & Schlager, J. J. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp712087m · Cited by 1,814
The Basic Science of Wound Healing
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000225430.42531.c2 · Cited by 1,519
Effect of silver on burn wound infection control and healing: Review of the literature
Atiyeh, B. S., Costagliola, M., Hayek, S. N., & Dibo, S. A. (2007) · Burns · doi:10.1016/j.burns.2006.06.010 · Cited by 1,267
Topical Delivery of Silver Nanoparticles Promotes Wound Healing
Tian, J., Wong, K. K. Y., Ho, C., Lok, C., Yu, W., Che, C., Chiu, J., & Tam, P. K. H. (2007) · ChemMedChem · doi:10.1002/cmdc.200600171 · Cited by 983
Self-citationEllis, H., Moran, B. J., Thompson, J. N., Parker, M. C., Wilson, M. S., Menzies, D., McGuire, A., Lower, A. M., Hawthorn, R. J., O'Brien, F., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09337-4 · Cited by 922
GENERAL PRINCIPLES OF WOUND HEALING
Witte, M. B., & Barbul, A. (1997) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70566-1 · Cited by 824
Vilcek, J., & Lee, T. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89445-9 · Cited by 582
Inflammatory cytokines and cell response in surgery
Lin, E., Calvano, S. E., & Lowry, S. F. (2000) · Surgery · doi:10.1067/msy.2000.101584 · Cited by 574
Subchronic Inhalation Toxicity of Silver Nanoparticles
Sung, J. H., Ji, J. H., Park, J. D., Yoon, J. U., Kim, D. S., Jeon, K. S., Song, M. Y., Jeong, J., Han, B. S., Han, J. H., et al. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn246 · Cited by 505
Rollins, B. J., Yoshimura, T., Leonard, E. J., & Pober, J. S. (1990) · Europe PMC (PubMed Central) · Cited by 492
Postoperative adhesions: Ten-year follow-up of 12,584 patients undergoing lower abdominal surgery
Parker, M. C., Ellis, H., Moran, B. J., Thompson, J. N., Wilson, M. S., Menzies, D., McGuire, A., Lower, A. M., Hawthorn, R. J. S., O'Brien, F., et al. (2001) · Diseases of the Colon & Rectum · doi:10.1007/bf02234701 · Cited by 371
Nitric oxide and intestinal inflammation
Kubes, P., & McCafferty, D.-M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00480-0 · Cited by 347
Shin, S.-H., Ye, M.-K., Kim, H.-S., & Kang, H.-S. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.08.025 · Cited by 288
Nanomedicine: Application of Nanobiotechnology in Medical Practice
Jain, K. K. (2008) · Medical Principles and Practice · doi:10.1159/000112961 · Cited by 247
Amelioration of collagen‐induced arthritis in rats by nanogold
Tsai, C., Shiau, A., Chen, S., Chen, Y., Cheng, P., Chang, M., Chen, D., Chou, C., Wang, C., & Wu, C. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22401 · Cited by 206
Cha, K., Hong, H.-W., Choi, Y.-G., Lee, M. J., Park, J. H., Chae, H.-K., Ryu, G., & Myung, H. (2008) · Biotechnology Letters · doi:10.1007/s10529-008-9786-2 · Cited by 181
De Laco, P. A., Stefanetti, M., Pressato, D., Piana, S., Donà, M., Pavesio, A., & Bovicelli, L. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00496-8 · Cited by 174
Bacteriology, Inflammation, and Healing
Sibbald, R. G., Contreras‐Ruiz, J., Coutts, P. M., Fierheller, M., Rothman, A. I., & Woo, K. Y. (2007) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000294757.05049.85 · Cited by 156
Watson, W. H., Zhao, Y., & Chawla, R. K. (1999) · Biochemical Journal · doi:10.1042/bj3420021 · Cited by 124
Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation
Kosaka, H., Yoshimoto, T., Yoshimoto, T., Fujimoto, J., & Nakanishi, K. (2008) · Nature Medicine · doi:10.1038/nm1733 · Cited by 108
Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late
Guirao, X., & Lowry, S. F. (1996) · World Journal of Surgery · doi:10.1007/s002689900069 · Cited by 102
Prevention of Postsurgical Adhesions with an Autocrosslinked Hyaluronan Derivative Gel
Belluco, C., Meggiolaro, F., Pressato, D., Pavesio, A., Bigon, E., Donà, M., Forlin, M., Nitti, D., & Lise, M. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6248 · Cited by 99
Dunn, R. C., Lyman, M. D., Edelman, P. G., & Campbell, P. K. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01677-0 · Cited by 98
CD4+ T Cells Regulate Surgical and Postinfectious Adhesion Formation
Chung, D. R., Chitnis, T., Panzo, R. J., Kasper, D. L., Sayegh, M. H., & Tzianabos, A. O. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020028 · Cited by 92
Increased bioavailability of a transdermal application of a nano-sized emulsion preparation
Kotyla, T., Kuo, F., Moolchandani, V., Wilson, T. A., & Nicolosi, R. J. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.045 · Cited by 67
Tumor Necrosis Factor-α: A Marker for Peritoneal Adhesion Formation
Kaidi, A. A., Gurchumelidze, T., Nazzal, M. M. S., Figert, P. L., Vanterpool, C. C., & Silva, Y. (1995) · Journal of Surgical Research · doi:10.1006/jsre.1995.1081 · Cited by 63
Herath, H. M. T., Takano‐Ishikawa, Y., & Yamaki, K. (2003) · Journal of Medicinal Food · doi:10.1089/109662003772519930 · Cited by 57
Induction of TNF-α by LPS in Schwann Cell is Regulated by MAPK Activation Signals
Cheng, C., Qin, Y., Shao, X., Wang, H., Gao, Y., Cheng, M., & Shen, A. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9215-4 · Cited by 46
Rafi, M. M., Yadav, P. N., & Rossi, A. O. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600226 · Cited by 42
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Zhang, X.-F., Liu, Z.-G., Shen, W., & Gurunathan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091534 · Cited by 3,220
Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Nosrati, H., Aramideh Khouy, R., Nosrati, A., Khodaei, M., Banitalebi-Dehkordi, M., Ashrafi-Dehkordi, K., Sanami, S., & Alizadeh, Z. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00755-7 · Cited by 720
An evaluation of blood compatibility of silver nanoparticles
Huang, H., Lai, W., Cui, M., Liang, L., Lin, Y., Fang, Q., Liu, Y., & Xie, L. (2016) · Scientific Reports · doi:10.1038/srep25518 · Cited by 186
Metadata
- Authors
- Wong, K. K. Y., Cheung, S. O. F., Huang, L., Niu, J., Tao, C., Ho, C., Che, C., & Tam, P. K. H.
- Venue
- ChemMedChem
- Publisher
- Wiley
- Published
- 2009-06-29
- Volume
- 4
- Issue
- 7
- Pages
- 1129-1135
- ISSN
- 1860-7179 (ISSN-L)
- 1860-7187
- OpenAlex
- W1965474648
- Cited by
- 269
- References
- 32
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
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