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Cited by 229Cancer survivorship and careHead and Neck Cancer StudiesShoulder Injury and Treatment

Effect of exercise on upper extremity pain and dysfunction in head and neck cancer survivors: A randomized controlled trial

McNeely, Margaret L., Parliament, Matthew B., Seikaly, Hadi, Jha, Naresh, Magee, David J., Haykowsky, Mark J., Courneya, Kerry S.·2008·Cancer
DOI 10.1002/cncr.23536
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Abstract

BACKGROUND.: Shoulder pain and disability are well recognized complications associated with surgery for head and neck cancer. This study was designed to examine the effects of progressive resistance exercise training (PRET) on upper extremity pain and dysfunction in postsurgical head and neck cancer survivors. METHODS.: Fifty‐two head and neck cancer survivors were assigned randomly to PRET (n = 27) or a standardized therapeutic exercise protocol (TP) (n = 25) for 12 weeks. The primary endpoint was change in patient‐rated shoulder pain and disability from baseline to postintervention. Secondary endpoints were upper extremity strength and endurance, range of motion, fatigue, and quality of life. RESULTS.: Follow‐up assessment for the primary outcome was 92%, and adherence to the supervised PRET and TP programs were 95% and 87%, respectively. On the basis of intention‐to‐treat analyses, PRET was superior to TP for improving shoulder pain and disability (−9.6; 95% confidence interval [95% CI], −16.4 to −4.5; P = .001), upper extremity strength (+10.8 kg; 95% CI, 5.4–16.2 kg; P < .001), and upper extremity endurance (+194 repetitions × kg; 95% CI, 10–378 repetitions × kg; P = .039). Changes in neck dissection impairment, fatigue, and quality of life favored the PRET group but did not reach statistical significance. CONCLUSIONS.: The PRET program significantly reduced shoulder pain and disability and improved upper extremity muscular strength and endurance in head and neck cancer survivors who had shoulder dysfunction because of spinal accessory nerve damage. Clinicians should consider the addition of PRET in the rehabilitation of postsurgical head and neck cancer survivors. Cancer 2008. © 2008 American Cancer Society.

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  • There is compelling evidence of a positive effect of exercise on cognitive function in older adults and other clinical populations.

    “While there is compelling evidence of a positive effect of exercise on cognitive function in older adults and other clinical populations(59), specific to cancer, more research is needed in cancer survivors where cognitive function is the primary outcome, and this outcome is assessed by both self-reported and standardized objective measures of cognitive function.”

    From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [59]

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Authors
McNeely, M. L., Parliament, M. B., Seikaly, H., Jha, N., Magee, D. J., Haykowsky, M. J., & Courneya, K. S.
Affiliations
  • Heritage Foundation (US)
  • University of Alberta (CA)
Corresponding author
McNeely, Margaret L.
ORCID
Venue
Cancer
Publisher
Wiley
Published
2008-06-20
Volume
113
Issue
1
Pages
214-222
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
DOI
10.1002/cncr.23536
OpenAlex
W2075935157
Cited by
229
References
24
Citations by year
2026: 5 · 2025: 8 · 2024: 17 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 24 · 2017: 15 · 2016: 9 · 2015: 9 · 2014: 16 · 2013: 15 · 2012: 18
FWCI
5.28
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Medicine › Surgery › Shoulder Injury and Treatment
Keywords
head and neck cancer survivors, shoulder pain, shoulder dysfunction, upper body strength, neck dissection, postoperative rehabilitation, fatigue, quality of life, range of motion
MeSH terms
Adult, Aged, Arm, Exercise Therapy, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Muscular Atrophy, Quality of Life, Treatment Outcome, Survivors, Shoulder Pain

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