The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits
Abstract
The fruitfly, Drosophila, is dependent on its olfactory sense in food search and reproduction. Processing of odorant information takes place in the antennal lobes, the primary olfactory center in the insect brain. Besides classical neurotransmitters, earlier studies have indicated the presence of a few neuropeptides in the olfactory system. In the present study we made an extensive analysis of the expression of neuropeptides in the Drosophila antennal lobes by direct profiling using matrix‐assisted laser desorption/ionization‐time‐of‐flight (MALDI‐TOF) mass spectrometry and immunocytochemistry. Neuropeptides from seven different precursor genes were unambiguously identified and their localization in neurons was subsequently revealed by immunocytochemistry. These were short neuropeptide F, tachykinin related peptide, allatostatin A, myoinhibitory peptide, SIFamide, IPNamide, and myosuppressin. The neuropeptides were expressed in subsets of olfactory sensory cells and different populations of local interneurons and extrinsic (centrifugal) neurons. In some neuron types neuropeptides were colocalized with classical neurotransmitters. Our findings suggest a huge complexity in peptidergic signaling in different circuits of the antennal lobe. J. Comp. Neurol. 518:3359–3380, 2010. © 2010 Wiley‐Liss, Inc.
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In the citing paper
“They seem to break Dale’s law104,106 and Lacin’s law (Figure 7C), with similar morphology types predicted to express different transmitters (Figures S5F and S5G).”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
In the citing paper
“The fan-shaped body is known to express leucokinin, allatostatin A, short neuropeptide F, Drosophila neuropeptide F, tachykinin, proctolin, dFMRFa, SIFamide and myoinhibitory peptide in a highly specific and layer-wise manner.106,175,177,184”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
In the citing paper
“transmitter usage in these local neurons seems to break Dale’s law,104,106 Lacin’s law (Figure 7C) and the expectation of uniform transmitter expression within a type (Figures S5F and S5G)”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
In the citing paper
“We suspect that some cholinergic local neurons have been mispredicted dopaminergic because at least ∼ 3 cholinergic neurons co-express allatostatin A and ∼ 10-15 co-express myoinhibitory peptide.106”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
In the citing paper
“Tachykinin is also known to co-express in ∼ 40 GABAergic ‘ALl1 dorsal’ neurons per hemisphere106”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
Citations
Cites
Coding of Odors by a Receptor Repertoire
Hallem, E. A., & Carlson, J. R. (2006) · Cell · doi:10.1016/j.cell.2006.01.050 · Cited by 1,286
An Olfactory Sensory Map in the Fly Brain
Vosshall, L. B., Wong, A. M., & Axel, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00021-0 · Cited by 1,090
Molecular, Anatomical, and Functional Organization of the Drosophila Olfactory System
Couto, A., Alenius, M., & Dickson, B. J. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.034 · Cited by 967
The organization of the chemosensory system in Drosophila melanogaster: a rewiew
Stocker, R. F. (1994) · Cell and Tissue Research · doi:10.1007/bf00305372 · Cited by 950
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
Kittel, R. J., Wichmann, C., Rasse, T. M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D. A., Pawlu, C., Kellner, R. R., Willig, K. I., et al. (2006) · Science · doi:10.1126/science.1126308 · Cited by 772
A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
Kurtović-Kozarić, A., Widmer, A., & Dickson, B. J. (2007) · Nature · doi:10.1038/nature05672 · Cited by 761
Genetic and Functional Subdivision of the Drosophila Antennal Lobe
Fishilevich, E., & Vosshall, L. B. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.066 · Cited by 608
Olfactory Perception: Receptors, Cells, and Circuits
Su, C., Menuz, K., & Carlson, J. R. (2009) · Cell · doi:10.1016/j.cell.2009.09.015 · Cited by 599
Invertebrate Synapsins: A Single Gene Codes for Several Isoforms inDrosophila
Klagges, B. R. E., Heimbeck, G., Godenschwege, T. A., Hofbauer, A., Pflugfelder, G. O., Reifegerste, R., Reisch, D., Schaupp, M., Buchner, S., & Buchner, E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03154.1996 · Cited by 489
Wilson, R. I., & Laurent, G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2070-05.2005 · Cited by 484
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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
Davie, K., Janssens, J., Koldere, D., De Waegeneer, M., Pech, U., Kreft, Ł., Aibar, S., Makhzami, S., Christiaens, V., Bravo González-Blas, C., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.057 · Cited by 840
Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search
Root, C. M., Ko, K. I., Jafari, A., & Wang, J. W. (2011) · Cell · doi:10.1016/j.cell.2011.02.008 · Cited by 526
Early Olfactory Processing in Drosophila: Mechanisms and Principles
Wilson, R. I. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150533 · Cited by 394
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 373
Self-citationNässel, D. R., & Wegener, C. (2011) · Peptides · doi:10.1016/j.peptides.2011.03.013 · Cited by 324
Self-citation
Metadata
- Authors
- Carlsson, M. A., Diesner, M., Schachtner, J., & Nässel, D. R.
- Affiliations
- Stockholm University (SE)
- Philipps University of Marburg (DE)
- Corresponding author
- Carlsson, Mikael A.
- Nässel, Dick R.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2010-06-23
- Volume
- 518
- Issue
- 16
- Pages
- 3359-3380
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1979540477
- Cited by
- 146
- References
- 92
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 12 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 13
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuropeptides, olfactory system, short neuropeptide F, tachykinin-related peptides, allatostatin A, myoinhibitory peptides, SIFamide, myosuppressin, olfactory sensory neurons, local interneurons, neurotransmitter co-localization, peptidergic signaling, olfactory processing
- MeSH terms
- Amino Acid Sequence, Animals, Brain, Drosophila melanogaster, Female, Hormone Antagonists, Interneurons, Male, Molecular Sequence Data, Neuropeptides, Olfactory Pathways, Smell, Signal Transduction, Olfactory Receptor Neurons, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Drosophila Proteins
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