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Cited by 394Neurobiology and Insect Physiology ResearchOlfactory and Sensory Function StudiesNeuroscience and Neuropharmacology Research

Early Olfactory Processing in Drosophila: Mechanisms and Principles

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Wilson, Rachel I.·2013·Annual Review of Neuroscience
DOI 10.1146/annurev-neuro-062111-150533PMC PMC3933953
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Abstract

In the olfactory system of Drosophila melanogaster, it is relatively straightforward to target in vivo measurements of neural activity to specific processing channels. This, together with the numerical simplicity of the Drosophila olfactory system, has produced rapid gains in our understanding of Drosophila olfaction. This review summarizes the neurophysiology of the first two layers of this system: the peripheral olfactory receptor neurons and their postsynaptic targets in the antennal lobe. We now understand in some detail the cellular and synaptic mechanisms that shape odor representations in these neurons. Together, these mechanisms imply that interesting neural adaptations to environmental statistics have occurred. These mechanisms also place some fundamental constraints on early sensory processing that pose challenges for higher brain regions. These findings suggest some general principles with broad relevance to early sensory processing in other modalities.

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  • These resources and tools have led to the emergence of data-constrained models of neural circuits.

    “These resources and tools have led to the emergence of data-constrained models of neural circuits (e.g., 43,44 ).”

    From NeuroMechFly v2: simulating embodied sensorimotor control in adult Drosophila (2024) · cites this paper as [44]

    The Introduction describes recording and genetic tools that transformed Drosophila neurophysiology, and “Some Fundamental Principles” discusses simulations of olfactory-circuit processing. The passages do not establish that those tools led to the emergence of data-constrained neural-circuit models specifically. (LLM, conf=0.76)

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Authors
Wilson, R. I.
Affiliations
Harvard University (US)
Corresponding author
Wilson, Rachel I.
ORCID
Wilson, Rachel I.
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
2013-07-08
Volume
36
Issue
1
Pages
217-241
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
DOI
10.1146/annurev-neuro-062111-150533
PMC
PMC3933953
OpenAlex
W2158976454
Cited by
394
References
10
Citations by year
2026: 19 · 2025: 32 · 2024: 28 · 2023: 43 · 2022: 27 · 2021: 47 · 2020: 39 · 2019: 24 · 2018: 28 · 2017: 34 · 2016: 26 · 2015: 24 · 2014: 19 · 2013: 4
FWCI
2.47
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute on Deafness and Other Communication Disorders (R01DC008174)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Drosophila olfaction, olfactory sensory neurons, antennal lobe, odor coding, synaptic mechanisms, neural adaptation, environmental statistics, early sensory processing
MeSH terms
Animals, Drosophila, Odorants, Olfactory Pathways, Smell, Olfactory Receptor Neurons

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