Cited by 484Retinal Development and DisordersGlaucoma and retinal disordersConnexins and lens biology

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The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

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Rodriguez, Allen R., de Sevilla Müller, Luis Pérez, Brecha, Nicholas C.·2014·Journal of Comparative Neurology

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Abstract

There are few neurochemical markers that reliably identify retinal ganglion cells (RGCs), which are a heterogeneous population of cells that integrate and transmit the visual signal from the retina to the central visual nuclei. We have developed and characterized a new set of affinity‐purified guinea pig and rabbit antibodies against RNA‐binding protein with multiple splicing (RBPMS). On western blots these antibodies recognize a single band at 〜24 kDa, corresponding to RBPMS, and they strongly label RGC and displaced RGC (dRGC) somata in mouse, rat, guinea pig, rabbit, and monkey retina. RBPMS‐immunoreactive cells and RGCs identified by other techniques have a similar range of somal diameters and areas. The density of RBPMS cells in mouse and rat retina is comparable to earlier semiquantitative estimates of RGCs. RBPMS is mainly expressed in medium and large DAPI‐, DRAQ5‐, NeuroTrace‐ and NeuN‐stained cells in the ganglion cell layer (GCL), and RBPMS is not expressed in syntaxin (HPC‐1)‐immunoreactive cells in the inner nuclear layer (INL) and GCL, consistent with their identity as RGCs, and not displaced amacrine cells. In mouse and rat retina, most RBPMS cells are lost following optic nerve crush or transection at 3 weeks, and all Brn3a‐, SMI‐32‐, and melanopsin‐immunoreactive RGCs also express RBPMS immunoreactivity. RBPMS immunoreactivity is localized to cyan fluorescent protein (CFP)‐fluorescent RGCs in the B6.Cg‐Tg(Thy1‐CFP)23Jrs/J mouse line. These findings show that antibodies against RBPMS are robust reagents that exclusively identify RGCs and dRGCs in multiple mammalian species, and they will be especially useful for quantification of RGCs. J. Comp. Neurol. 522:1411–1443, 2014. © 2013 Wiley Periodicals, Inc.

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Authors: Rodriguez, A. R., de Sevilla Müller, L. P., & Brecha, N. C.
Affiliations: University of California, Los Angeles (US)
Department of Neurobiology David Geffen School of Medicine at Los Angeles, University of California at Los Angeles Los Angeles California 90095‐1763
Corresponding author: Brecha, Nicholas C.
ORCID: Brecha, Nicholas C.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2014-03-14
Volume: 522
Issue: 6
Pages: 1411-1443
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.23521
PMC: PMC3959221
OpenAlex: W1960721561
Cited by: 483
References: 128
Citations by year: 2026: 34 · 2025: 39 · 2024: 50 · 2023: 43 · 2022: 41 · 2021: 60 · 2020: 50 · 2019: 55 · 2018: 36 · 2017: 27 · 2016: 26 · 2015: 14 · 2014: 8
FWCI: 7.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (IK6 BX005230, I01 BX000764)
National Eye Institute (EY-014127, R01EY014127, R56EY004067, R01EY004067, EY 04067)
National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK 41301, P30DK041301)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD018655, P30HD-18655)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords: RBPMS, retinal ganglion cells, neurochemical markers, ganglion cell layer, optic nerve crush, Brn3a, SMI-32, melanopsin, antibody specificity
MeSH terms: Melanopsin, Animals, Female, Guinea Pigs, Macaca mulatta, Male, Mammals, Mice, Inbred C57BL, Nerve Tissue Proteins, Optic Nerve Diseases, Rabbits, Retina, Retinal Ganglion Cells, Species Specificity, RNA-Binding Proteins, Rats, Sprague-Dawley, Rod Opsins, Transcription Factor Brn-3A, Mice, Rats

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The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

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