An ocular glymphatic clearance system removes β-amyloid from the rodent eye
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Glymphatic pathway clears retinal β-amyloid in rodents via optic nerve and is impaired in glaucoma.
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Glymphatic fluid transport is directionally polarized: influx along penetrating arteries, AQP4-supported entry into neuropil, and efflux along peri-venous spaces and cranial and spinal nerves.
“fluid transport through the glymphatic system is directionally polarized, with influx along penetrating arteries, fluid entry into the neuropil supported by AQP4, and efflux along the peri-venous spaces, as well as along the cranial and spinal nerves (24, 32–34).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [33]
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Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study
Holmlund, P., Støverud, K.-H., Wåhlin, A., Wiklund, U., Malm, J., Jóhannesson, G., & Eklund, A. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.4.26 · Cited by 10 · see citing works
- Authors
- Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Förstera, B., Peng, S., Shi, M., Ladrón-de-Guevara, A., Delle, C., Sigurdsson, B., Xavier, A. L. R., Ertürk, A., Libby, R. T., Chen, L., Thrane, A. S., & Nedergaard, M.
- Affiliations
- University of Copenhagen (DK)
- University of Rochester Medicine (US)
- University of California, Berkeley (US)
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
- Helmholtz Munich (DE)
- Corresponding author
- Chen, Lu
- Nedergaard, Maiken
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-03-25
- Volume
- 12
- Issue
- 536
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7356596
- OpenAlex
- W3013081630
- Cited by
- 239
- References
- 91
- Citations by year
- 2026: 35 · 2025: 50 · 2024: 48 · 2023: 27 · 2022: 24 · 2021: 34 · 2020: 20
- FWCI
- 20.82
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- National Institutes of Health (AG057575, NS100366, EY028995)
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Cure Alzheimer’s Fund
- H2020 European Research Council (742112)
- Lundbeckfonden
- Novo Nordisk Fonden
- Research to Prevent Blindness Foundation (Stein Innovation Award)
- Western Norway Regional Health Authority (Helse Vest grants no. 912179 and 912230)
- Norwegian Glaucoma Research Foundation
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- amyloid-beta clearance, aquaporin-4, optic nerve, glaucoma, intraocular pressure, miosis, vitreous humor, lymphatic drainage, retina
- MeSH terms
- Glymphatic System, Animals, Intracranial Pressure, Optic Nerve, Retina, Vitreous Body, Amyloid beta-Peptides, Mice, Aquaporin 4
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