The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Dopaminergic neurons in the human retina
Abstract
The utilization of dopamine in the adult human retina was examined by using high‐affinity uptake, localization, synthesis, and release as neurotransmitter‐specific physiological probes. Autoradiographic and histochemical studies have shown that dopamine‐accumulating and dopamine‐containing cells of the human retina belong to a population of neurons whose somata are located in the proximal regions of the inner nuclear layer. Some of these are amacrine cells which are pre‐and postsynaptic to other amacrine cells exclusively in the inner plexiform layer. However, evidence is presented which indicates the existence of interplexiform dopaminergic neurons which send processes to both plexiform layers of the retina. These neurons contain a high concentration of dopamine, take up 3 H‐dopamine by a high‐affinity mechanism, and release endogenous or accumulated dopamine by a Ca 2+‐dependent mechanism upon depolarization with high extracellular K+. An endogenous level of about 20 pmoles dopamine per mg protein was measured in freshly isolated retina using high‐pressure liquid chromatography with electrochemical detection. These results demonstrate that mechanisms for dopaminergic neurotransmission are present in the human retina.
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Cites
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The interplexiform cell system - I. Synapses of the dopaminergic neurons of the goldfish retina
Dowling, J. E., & Ehinger, B. (1978) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1978.0030 · Cited by 355
Neurotransmission in central nervous tissue: a study of isolated rabbit retina.
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Screening for neurotransmitters: A rapid radiochemical procedure
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The interplexiform cell system II. Effects of dopamine on goldfish retinal neurones
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Dopaminergic Mechanisms in the Teleost Retina
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Self-citation
Cited by
Visual dysfunction in Parkinson’s disease
Weil, R. S., Schrag, A. E., Warren, J. D., Crutch, S. J., Lees, A. J., & Morris, H. R. (2016) · Brain · doi:10.1093/brain/aww175 · Cited by 481
“The healthy human retina contains dopaminergic amacrine cells (Frederick et al., 1982) and patients with Parkinson’s disease have reduced dopamine innervation around the fovea (Nguyen-Legros, 1988).”
BackgroundBodis-Wollner, I. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90113-o · Cited by 296
Neuroprotective strategies for retinal disease
Pardue, M. T., & Allen, R. S. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.02.002 · Cited by 237
Metadata
- Authors
- Frederick, J. M., Rayborn, M. E., Laties, A. M., Lam, D. M. K., & Hollyfield, J. G.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1982-09
- Volume
- 210
- Issue
- 1
- Pages
- 65-79
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1972653353
- Cited by
- 277
- References
- 15
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frederick, J. M., Rayborn, M. E., Laties, A. M., Lam, D. M. K., & Hollyfield, J. G. (1982). Dopaminergic neurons in the human retina. Journal of Comparative Neurology. https://doi.org/10.1002/cne.902100108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
