Neuroprotective strategies for retinal disease

Pardue, Machelle T.; Allen, Rachael S.

doi:10.1016/j.preteyeres.2018.02.002

Cited by 237Retinal Development and DisordersRetinal Diseases and TreatmentsGlaucoma and retinal disorders

Neuroprotective strategies for retinal disease

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Pardue, Machelle T., Allen, Rachael S.·2018·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2018.02.002PMC PMC6081194

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Abstract

Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic burden both on individuals and the greater healthcare system. Despite the urgent need for treatments, few effective options currently exist in the clinic. Here, we review research on promising neuroprotective strategies that promote neuronal survival with the potential to protect against vision loss and retinal cell death. Due to the large number of neuroprotective strategies, we restricted our review to approaches that we had direct experience with in the laboratory. We focus on drugs that target survival pathways, including bile acids like UDCA and TUDCA, steroid hormones like progesterone, therapies that target retinal dopamine, and neurotrophic factors. In addition, we review rehabilitative methods that increase endogenous repair mechanisms, including exercise and electrical stimulation therapies. For each approach, we provide background on the neuroprotective strategy, including history of use in other diseases; describe potential mechanisms of action; review the body of research performed in the retina thus far, both in animals and in humans; and discuss considerations when translating each treatment to the clinic and to the retina, including which therapies show the most promise for each retinal disease. Despite the high incidence of retinal diseases and the complexity of mechanisms involved, several promising neuroprotective treatments provide hope to prevent blindness. We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.

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Neuroprotective factors such as GDNF, CNTF, BDNF, basic fibroblast growth factor, and PEDF have shown promise in mouse models of retinal degeneration.
“Neuroprotective factors that support the survival of retinal cells, such as glial cell-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), brain-derived neurotrophic factor (BDNF), basic fibroblast growth factor, and pigment epithelium-derived factor (PEDF) have shown promise in mouse models of retinal degeneration.67,103–105”
From Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions (2023) · cites this paper as [104]

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Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration
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Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain
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Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment
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Progesterone Exacerbates Striatal Stroke Injury in Progesterone-Deficient Female Animals
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Noninvasive transorbital alternating current stimulation improves subjective visual functioning and vision-related quality of life in optic neuropathy
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Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects
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Electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo
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Neuroprotective Effect of Transcorneal Electrical Stimulation on the Acute Phase of Optic Nerve Injury
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Transcorneal Electrical Stimulation for Patients With Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Follow-up Study Over 1 Year
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TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice
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Electrical stimulation of visual cortex: relevance for the development of visual cortical prosthetics
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Impaired Visual Acuity as a Risk Factor for Visual Hallucinations in Parkinson’s Disease
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Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion
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Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor
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Tool from ancient pharmacopoeia prevents vision loss.
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Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a BDNF ‐dependent pathway
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Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats
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Cone Structure Imaged With Adaptive Optics Scanning Laser Ophthalmoscopy in Eyes With Nonneovascular Age-Related Macular Degeneration
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Restoration of vision after optic nerve lesions with noninvasive transorbital alternating current stimulation: a clinical observational study
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Authors: Pardue, M. T., & Allen, R. S.
Affiliations: Georgia Institute of Technology (US)
Atlanta VA Medical Center (US)
Corresponding author: Pardue, Machelle T.
ORCID: Pardue, Machelle T.
Allen, Rachael S.
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2018-07
Volume: 65
Pages: 50-76
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2018.02.002
PMC: PMC6081194
OpenAlex: W2793623156
Cited by: 237
References: 416
Citations by year: 2026: 21 · 2025: 24 · 2024: 30 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 32 · 2019: 19 · 2018: 5 · 2017: 1
FWCI: 2.28
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Progress in Retinal and Eye Research (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: IRB
National Institutes of Health (P30 EY006360)
Rehabilitation R&D Service of the Department of Veterans Affairs (I01RX000951)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords: neuroprotection, retinal disease, photoreceptor degeneration, diabetic retinopathy, glaucoma, vision loss, bile acids, ursodeoxycholic acid, tauroursodeoxycholic acid, progesterone, retinal dopamine, neurotrophic factors, exercise therapy, electrical stimulation, retinal cell death, translational therapy
MeSH terms: Animals, Electric Stimulation Therapy, Exercise Therapy, Humans, Nerve Growth Factors, Neurons, Retina, Retinal Diseases, Taurochenodeoxycholic Acid, Ursodeoxycholic Acid, Vision Disorders, Cell Death, Neuroprotective Agents

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