Luteinizing hormone‐releasing hormone (LHRH) in rat olfactory systems

Witkin, Joan W.; Silverman, Ann‐Judith

doi:10.1002/cne.902180407

Cited by 97Olfactory and Sensory Function StudiesHypothalamic control of reproductive hormonesNeurogenesis and neuroplasticity mechanisms

Luteinizing hormone‐releasing hormone (LHRH) in rat olfactory systems

Witkin, Joan W., Silverman, Ann‐Judith·1983·Journal of Comparative Neurology

DOI 10.1002/cne.902180407

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Abstract

The luteinizing hormone-releasing hormone (LHRH) systems of rat olfactory bulbs and nasal areas were studied in neonatal and adult rats. Animals were perfused with Zamboni's fixative and olfactory bulbs with nasal olfactory areas intact were removed, postfixed, and decalcified. LHRH was immunohistochemically demonstrated in unembedded frozen or vibratome sections. Luteinizing hormone-releasing hormone immunoreactive elements were found along the course of the nervus terminalis (NT) and within both the main and accessory olfactory bulbs (MOB and AOB, respectively). Both LHRH neurons and fibers were present in the AOB, but only fibers were detected in the MOB. The fibers of the AOB were not confined to any particular lamina while fibers in the MOB were found mainly in the external plexiform layer. LHRH fibers were found in the mucosa of the olfactory epithelium of the vomeronasal organ in both neonatal and adult rats. The NT probably serves as a source of LHRH fibers for both the AOB and the MOB and for fibers observed in the olfactory epithelium of the vomeronasal organ. Other likely sources of LHRH fibers in the olfactory bulb are discussed.

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There is no evidence that the nervus terminalis is chemosensory or that the human terminalis nerve carries the axons of VSNs, but it may innervate the vomeronasal epithelium.
“There is no evidence that this nerve is chemosensory or that the human terminalis nerve carries the axons of VSNs (although the two do run together in most mammals), but it may innervate the vomeronasal epithelium (Witkin and Silverman, 1983;Wirsig and Leonard, 1986).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Witkin and Silverman, 1983

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Immunocytochemical localization of luteinizing hormone-releasing hormone within the olfactory bulb of pigs.
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“In other species in which olfactory cues have a profound influence on reproductive behavior and physiology, immunoreactive LHRH is found within olfactory-related neuroanatomical pathways [21-26].”
Background
Olfactory bulbectomy prevents short photoperiod-induced anestrus in female golden hamsters.
Pieper, D. R., Samyn, M. M., & Heverly, R. N. (1986) · Brain Research · doi:10.1016/0006-8993(86)91428-9 · Cited by 7 · see citing works
Interactions between the Olfactory System and the Terminal Nerve Electrophysiological Evidence
Meredith, M., & White, J. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb36309.x · Cited by 6 · see citing works
Cranial nerve 13.
Pineda, A., Leon-Sarmiento, F. E., & Doty, R. (2019) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-63855-7.00009-5 · Cited by 5 · see citing works
Gonadotropin-Releasing Hormone: Differentiation of Structure and Function During Evolution
Sherwood, N. (1986) · doi:10.1007/978-1-4684-5131-3_7 · Cited by 5
Attempts to immunoprecipitate the LHRH precursor synthesized in cell free systems.
Cohen, S., Charli, J., León, L. D. D., Millar, R. P., Arimura, A., Morrison, M., & Joseph-Bravo, P. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90050-x · Cited by 3
Electrophysiological Studies into Circuitry Involved in LHRH-Mediated Sexual Behavior
Dudley, C., & Moss, R. L. (1986) · doi:10.1007/978-1-4684-5152-8_10 · Cited by 3
Passive immunization of fetal rats with antiserum to luteinizing hormone-releasing hormone (LHRH) or transection of the central roots of the nervus terminalis does not affect rat pups' preference for home nest.
Schwanzel-Fukuda, M., & Pfaff, D. (1987) · Physiology and Behavior · doi:10.1016/0031-9384(87)90319-2 · Cited by 2
Identification of the Terminal Nerve in Two Amphibians Shown by the Localization of LHRH‐like Material and AChE a
Wirsig, C., & Getchell, T. V. (1987) · doi:10.1111/j.1749-6632.1987.tb43676.x · Cited by 1
Activation and degeneration during aging: a morphometric study of the human hypothalamus
Schwanzel-Fukuda (1999) · Pure Amsterdam UMC · doi:10.1002/(sici)1097-0029(19990101)44:1
MODELLI SPERIMENTALI DI SOVRACCARICO DIETETICO DI FERRO: EFFETTI CENTRALI E PERIFERICI SU METABOLISMO E FUNZIONE RIPRODUTTIVA
Steffani, L. (2014) · doi:10.13130/steffani-liliana_phd2014-02-10
“Durante lo sviluppo embrionale di numerosi vertebrati quali il topo, il ratto [17, 18], la rana, la tartaruga, il delfino, la balena, il maiale, il pollo [19, 20], la scimmia [21] e l’uomo [22] è stata osservata la migrazione dei neuroni GnRH dalla parte mediale del”
Background
Neuromodulator role of luliberin in the regulation of sexual behavior in the male rat
Babichev, V., Adamskaya, E., Ozol', L. Y., & El'tseva, T. V. (1991) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01191574
Correlation between changes in LH-RH content in the synaptosomal fraction of the olfactory bulb and some hypothalamic zones and level of sexual activity in male rats
El'tseva, T. V., Adamskaya, E., Ozol', L. Y., & Babichev, V. (1989) · Neuroscience and Behavioral Physiology · doi:10.1007/bf01188549
Theories of Luteinizing Hormone Releasing Hormone Neuronal Migration: Mechanisms and Biological Importance
Schwanzel-Fukuda, M., & Pfaff, D. (1992) · Springer eBooks · doi:10.1007/978-1-4612-2916-2_9
The Physiological Actions of LHRH — Evidence from the Hypogonadal (hpg) Mouse
Charlton, H. M. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5131-3_5

Authors: Witkin, J. W., & Silverman, A.
Affiliations: Columbia University (US)
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1983-08-20
Volume: 218
Issue: 4
Pages: 426-432
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.902180407
OpenAlex: W2067699638
Cited by: 96
References: 28
Citations by year: 2021: 1 · 2020: 1 · 2019: 1
FWCI: 6.56
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7721 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Whitehall Foundation
U.S. Public Health Service
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: gonadotropin-releasing hormone, olfactory bulb, accessory olfactory bulb, main olfactory bulb, terminal nerve, vomeronasal organ, olfactory epithelium, outer plexiform layer, neonatal rats, rats
MeSH terms: Animals, Animals, Newborn, Central Nervous System, Female, Gonadotropin-Releasing Hormone, Male, Olfactory Bulb, Olfactory Mucosa, Olfactory Pathways, Sense Organs, Smell, Rats

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Luteinizing hormone‐releasing hormone (LHRH) in rat olfactory systems

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