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Cited by 124Neurogenesis and neuroplasticity mechanismsVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development

Williams, Robert W., Rakic, Pasko·1988·Journal of Comparative Neurology
DOI 10.1002/cne.902720310
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Abstract

The timing, magnitude, and spatial distribution of neuron elimination was studied in the dorsal lateral geniculate nucleus of 57 rhesus monkeys (Macaca mulatta) ranging in age from the 48th day of gestation to maturity. Normal and degenerating cells were counted in Nissl‐stained sections by using video‐enhanced differential interference contrast optics and videooverlay microscopy. Before embryonic day 60 (E60), the geniculate nucleus contains 2,200,000 ± 100,000 neurons. Roughly 800,000 of these neurons are eliminated over a 40‐ to 50‐day period spanning the middle third of gestation. Neurons are lost at an average rate of 300 an hour between E48 and E60, and at an average rate of 800 an hour between E60 and E100. Very few neurons are lost after E100, and as early as E103 the population has fallen to the adult average of 1,400,000 ± 90,000. Degenerating neurons are far more common in the magnocellular part of the nucleus than in the parvicellular part. In 20 of 29 cases, the number of neurons is greater on the right than on the left side. The right‐left asymmetry averages about 8.5% and the difference is statistically significant (X 2 = 38, p< .001). The period of cell death occurs before the emergence of cell layers in the geniculate nucleus, before the establishment of geniculocortical connections, and before the formation of ocular dominance columns (Rakic, 76). Most important, the depletion of neurons in the geniculate nucleus begins long before the depletion of retinal axons. The number of geniculate neurons is probably a key factor controlling the number of the retinal cells that survive to maturity.

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Research works printed but not linked: 13

  1. Balado M., 1937, Das Corpus Geniculatum Externum. Eine anatomischklinische Studie, Monographien aus dem Gesamtgebiete der Neurologie and Psychiatrie, 62, 1
  2. Bourgeois J.‐P., 1983, Synaptogenesis in the primary visual cortex; Quantitative analysis in pre‐ and postnatal rhesus monkeys, Soc. Neurosci. Abst., 9, 692
  3. Chalupa L. M., 1985, Advances in Neuronal and Behavioral Development, 1
  4. Hendrickson A. E., 1977, Histogenesis and synaptogenesis in the dorsal lateral geniculate nucleus (LGd) of the fetal monkey brain, Anat. Rec., 187, 602
  5. LaVail M. M., 1983, Cell genesis in the rhesus monkey retina, Invest. Ophthalmol. Vis. Sci., 24, 7
  6. McAloon K., 1972, Calculus
  7. Ogren M. P., 1984, Consequences of prenatal striate cortex lesions on retinogeniculate projection in the monkey, Invest. Ophthalmol. Vis. Sci., 24, 64
  8. Oppenheim R. W., 1988, Handbook of Physiology, Development of the Nervous System
  9. Pasik P., 1986, GABA immunoreactivity in monkey lateral geniculate nucleus (LGN) at light and electron microscopic levels, Soc. Neurosci. Abs., 11, 317
  10. Rakic P., 1986, Thalamic regulation of cortical parcellation: An experimental perturbation of the striate cortex in rhesus monkeys, Soc. Neurosci. Abst., 12, 1499
  11. Williams R. W., 1985, Number of neurons in the monkey's dorsal lateral geniculate nucleus during development, Soc. Neurosci. Abs., 11, 804
  12. Williams R. W., 1986, Pronounced architectonic differences between monocular and binocular segments of the monkeys striate cortex, Soc. Neurosci. Abst., 12, 1498
  13. Williams R. W., 1987, Emergence of cytoarchitectonic differences between areas 17 and 18 in the developing rhesus monkey, Soc. Neurosci. Abst., 13, 1044

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Metadata

Authors
Williams, R. W., & Rakic, P.
Affiliations
Yale University (US)
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1988-06-15
Volume
272
Issue
3
Pages
424-436
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902720310
OpenAlex
W2004130336
Cited by
124
References
81
Citations by year
2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5960 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Eye Institute (EY02593, EY 06627)
  • National Institute of Neurological Disorders and Stroke (NS-22807)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal elimination, lateral geniculate nucleus, rhesus monkeys, developmental cell death, magnocellular neurons, parvicellular neurons, left-right asymmetry, ocular dominance columns, embryonic development
MeSH terms
Animals, Cell Count, Embryonic and Fetal Development, Geniculate Bodies, Immunochemistry, Macaca, Macaca mulatta, Nerve Degeneration, Neurons

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