Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition
Abstract
Autoradiographic evidence after injection of tritiated thymidine indicates that cell position in the laminae of the monkey visual cortex is systematically related to time of cell origin. The earliest-formed neurons, destined for the deepest stratum, arise at about embryonic day 45, and the last ones, destined for the outermost cell stratum, form at about day 102; cells of intervening layers are generated at intervening times. No neocortical neurons are produced in the last two prenatal months or after birth. Compared to cortical neurons in rodents, those in the monkey arise earlier, and the "inside-out" relation of cell position to time of origin is more rigid.
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The generation of the six-layer cortical plate occurs in an inside-out fashion, with early-born neurons establishing layer 6, then layer 5, and so forth.
“The generation of the six-layer cortical plate occurs in an inside-out fashion, with the early-born neurons establishing layer 6, then layer 5, and so forth59.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [59]
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“The generation of the six-layer cortical plate occurs in an inside-out fashion, with the early-born neurons establishing layer 6, then layer 5, and so forth 59 .”
- Authors
- Rakic, P.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Rakic, Pasko
- ORCID
- Rakic, Pasko
- Venue
- Science
- Published
- 1974-02
- Volume
- 183
- Issue
- 4123
- Pages
- 425-427
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979952856
- Cited by
- 1,161
- References
- 1
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 19 · 2023: 34 · 2022: 30 · 2021: 28 · 2020: 44 · 2019: 31 · 2018: 36 · 2017: 27 · 2016: 38 · 2015: 29 · 2014: 23 · 2013: 35 · 2012: 26
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- visual cortex, rhesus monkeys, neuronal origin, 3H-thymidine autoradiography, neocortex development
- MeSH terms
- Animals, Haplorhini, Autoradiography, Brain Mapping, Cell Differentiation, Cell Movement, Female, Gestational Age, Macaca, Neurons, Pregnancy, Thymidine, Tritium, Visual Cortex
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