CoChat
Sign Up
Cited by 124Neurogenesis and neuroplasticity mechanismsVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development

Williams, Robert W., Rakic, Pasko·1988·Journal of Comparative Neurology
DOI 10.1002/cne.902720310
Open this paper in CoChat — free account

Abstract

The timing, magnitude, and spatial distribution of neuron elimination was studied in the dorsal lateral geniculate nucleus of 57 rhesus monkeys (Macaca mulatta) ranging in age from the 48th day of gestation to maturity. Normal and degenerating cells were counted in Nissl‐stained sections by using video‐enhanced differential interference contrast optics and videooverlay microscopy. Before embryonic day 60 (E60), the geniculate nucleus contains 2,200,000 ± 100,000 neurons. Roughly 800,000 of these neurons are eliminated over a 40‐ to 50‐day period spanning the middle third of gestation. Neurons are lost at an average rate of 300 an hour between E48 and E60, and at an average rate of 800 an hour between E60 and E100. Very few neurons are lost after E100, and as early as E103 the population has fallen to the adult average of 1,400,000 ± 90,000. Degenerating neurons are far more common in the magnocellular part of the nucleus than in the parvicellular part. In 20 of 29 cases, the number of neurons is greater on the right than on the left side. The right‐left asymmetry averages about 8.5% and the difference is statistically significant (X 2 = 38, p< .001). The period of cell death occurs before the emergence of cell layers in the geniculate nucleus, before the establishment of geniculocortical connections, and before the formation of ocular dominance columns (Rakic, 76). Most important, the depletion of neurons in the geniculate nucleus begins long before the depletion of retinal axons. The number of geniculate neurons is probably a key factor controlling the number of the retinal cells that survive to maturity.

Overview

Integrity signals

Registry

Crossref · 10.1002/cne.902720310

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 81 references

Research works printed but not linked: 13

  1. Balado M., 1937, Das Corpus Geniculatum Externum. Eine anatomischklinische Studie, Monographien aus dem Gesamtgebiete der Neurologie and Psychiatrie, 62, 1
  2. Bourgeois J.‐P., 1983, Synaptogenesis in the primary visual cortex; Quantitative analysis in pre‐ and postnatal rhesus monkeys, Soc. Neurosci. Abst., 9, 692
  3. Chalupa L. M., 1985, Advances in Neuronal and Behavioral Development, 1
  4. Hendrickson A. E., 1977, Histogenesis and synaptogenesis in the dorsal lateral geniculate nucleus (LGd) of the fetal monkey brain, Anat. Rec., 187, 602
  5. LaVail M. M., 1983, Cell genesis in the rhesus monkey retina, Invest. Ophthalmol. Vis. Sci., 24, 7
  6. McAloon K., 1972, Calculus
  7. Ogren M. P., 1984, Consequences of prenatal striate cortex lesions on retinogeniculate projection in the monkey, Invest. Ophthalmol. Vis. Sci., 24, 64
  8. Oppenheim R. W., 1988, Handbook of Physiology, Development of the Nervous System
  9. Pasik P., 1986, GABA immunoreactivity in monkey lateral geniculate nucleus (LGN) at light and electron microscopic levels, Soc. Neurosci. Abs., 11, 317
  10. Rakic P., 1986, Thalamic regulation of cortical parcellation: An experimental perturbation of the striate cortex in rhesus monkeys, Soc. Neurosci. Abst., 12, 1499
  11. Williams R. W., 1985, Number of neurons in the monkey's dorsal lateral geniculate nucleus during development, Soc. Neurosci. Abs., 11, 804
  12. Williams R. W., 1986, Pronounced architectonic differences between monocular and binocular segments of the monkeys striate cortex, Soc. Neurosci. Abst., 12, 1498
  13. Williams R. W., 1987, Emergence of cytoarchitectonic differences between areas 17 and 18 in the developing rhesus monkey, Soc. Neurosci. Abst., 13, 1044

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Williams, R. W., & Rakic, P.
Affiliations
Yale University (US)
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1988-06-15
Volume
272
Issue
3
Pages
424-436
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902720310
OpenAlex
W2004130336
Cited by
124
References
81
Citations by year
2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5960 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Eye Institute (EY02593, EY 06627)
  • National Institute of Neurological Disorders and Stroke (NS-22807)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal elimination, lateral geniculate nucleus, rhesus monkeys, developmental cell death, magnocellular neurons, parvicellular neurons, left-right asymmetry, ocular dominance columns, embryonic development
MeSH terms
Animals, Cell Count, Embryonic and Fetal Development, Geniculate Bodies, Immunochemistry, Macaca, Macaca mulatta, Nerve Degeneration, Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review