Cited by 843Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.

A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat

Vertes, Robert P.·1991·Journal of Comparative Neurology

DOI 10.1002/cne.903130409

Open this paper in CoChat — free account

Abstract

Ascending projections from the dorsal raphe nucleus (DR) were examined in the rat by using the anterograde anatomical tracer, Phaseolus vulgaris leucoagglutinin (PHA-L). The majority of labeled fibers from the DR ascended through the forebrain within the medial forebrain bundle. DR fibers were found to terminate heavily in several subcortical as well as cortical sites. The following subcortical nuclei receive dense projections from the DR: ventral regions of the midbrain central gray including the 'supraoculomotor central gray' region, the ventral tegmental area, the substantia nigra-pars compacta, midline and intralaminar nuclei of the thalamus including the posterior paraventricular, the parafascicular, reuniens, rhomboid, intermediodorsal/mediodorsal, and central medial thalamic nuclei, the central, lateral and basolateral nuclei of the amygdala, posteromedial regions of the striatum, the bed nucleus of the stria terminalis, the lateral septal nucleus, the lateral preoptic area, the substantia innominata, the magnocellular preoptic nucleus, the endopiriform nucleus, and the ventral pallidum. The following subcortical nuclei receive moderately dense projections from the DR: the median raphe nucleus, the midbrain reticular formation, the cuneiform/pedunculopontine tegmental area, the retrorubral nucleus, the supramammillary nucleus, the lateral hypothalamus, the paracentral and central lateral intralaminar nuclei of the thalamus, the globus pallidus, the medial preoptic area, the vertical and horizontal limbs of the diagonal band nuclei, the claustrum, the nucleus accumbens, and the olfactory tubercle. The piriform, insular and frontal cortices receive dense projections from the DR; the occipital, entorhinal, perirhinal, frontal orbital, anterior cingulate, and infralimbic cortices, as well as the hippocampal formation, receive moderately dense projections from the DR. Some notable differences were observed in projections from the caudal DR and the rostral DR. For example, the hippocampal formation receives moderately dense projections from the caudal DR and essentially none from the rostral DR. On the other hand, virtually all neocortical regions receive significantly denser projections from the rostral than from the caudal DR. The present results demonstrate that dorsal raphe fibers project significantly throughout widespread regions of the midbrain and forebrain.

Integrity signals

Registry

Crossref · 10.1002/cne.903130409

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Azmitia, E. C., & Segal, M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790311 · Cited by 1,908
Chemical Neuroanatomy
Emson, P. C., Heffher, R. R., & Pearson, J. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198409000-00010 · Cited by 1,651
Efferent connections of the substantia nigra and ventral tegmental area in the rat
Beckstead, R. M., Domesick, V. B., & Nauta, W. J. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)91001-1 · Cited by 1,293
The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat
Krettek, J. E., & Price, J. L. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901710204 · Cited by 1,277
An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: Immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris-leucoagglutinin (PHA-L)
Gerfen, C. R., & Sawchenko, P. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)90940-5 · Cited by 1,205
Organization of motor and somatosensory neocortex in the albino rat
Hall, R. D., & Lindholm, E. P. (1974) · Brain Research · doi:10.1016/0006-8993(74)90076-6 · Cited by 897
The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods
Kelley, A. E., Domesick, V. B., & Nauta, W. J. H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90067-7 · Cited by 888
The prefrontal cortex of the rat. I. cortical projection of the mediodorsal nucleus. II. efferent connections
Leonard, C. M. (1969) · Brain Research · doi:10.1016/0006-8993(69)90003-1 · Cited by 850

Show all 138 references

Research works printed but not linked: 9

Fraser H., 1976, Slow Virus Disease of Animals and Man, 267
Irle E., 1986, Afferent connections of the subatantia innominata/basal nucleus of Meynert in carnivores and primates, J. Hirnforsch., 27, 343
Klein J., 1985, The new drug they call “Ecstasy”. Is it too much to swallow?, 38
Pasik T., 1982, Serontonergic afferents in the monkey neostriatum, Acta Biol. Sci. Hung., 33, 277
Vertes R. P., 1989, An anterograde PHA study of the efferent projections of the dorsal raphe nucleus in the rat, Neurosci Abstr., 15, 450
Vertes R. P., 1990, Brainstem Mechanisms of Behaviour, 33
Vertes R. P., 1990, Brainstem Mechanisms of Behaviour, 535
Zilles K., 1985, A stereotaxi atlas
Zilles K., 1985, The Rat Nervous System, 375

Sorted by citations

Items 101–200 of 843

Identification and distribution of projections from monoaminergic and cholinergic nuclei to functionally differentiated subregions of prefrontal cortex
Chandler, D. J., Lamperski, C. S., & Waterhouse, B. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.04.057 · Cited by 168
“…of the efferent topography of the nucleus (Abrams et al., 2004; Kirifides et al., 2001; O'Hearn and Molliver, 1984; Van Bockstaele et al., 1993; Vertes, 1991; Villar et al., 1988; Waterhouse et al., 1986, 1993) such that the majority of retrogradely labeled cells were found in the rostral and…”
Background
Identification of a Brainstem Circuit Controlling Feeding
Nectow, A. R., Schneeberger, M., Zhang, H., Field, B. C., Renier, N., Azevedo, E. P., Patel, B., Liang, Y., Mitra, S. S., Tessier‐Lavigne, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.045 · Cited by 172
“, 1994; Fletcher and Davies, 1990), the DRN projects to many regions known to control feeding (Vertes, 1991; Vertes and Kocsis, 1994), and subsets of DRN neurons are activated by feeding (Fornal et al.”
Background
Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms
Brown, C. H., Bains, J. S., Ludwig, M., & Stern, J. E. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12051 · Cited by 179
CNS inputs to the suprachiasmatic nucleus of the rat
Krout, K. E., Kawano, J., Mettenleiter, T. C., & Loewy, A. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00551-6 · Cited by 172
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of α2‐adrenergic and serotonin2C receptors: a comparison with citalopram
Millan, M. J., Gobert, A., Rivet, J., Adhumeau-Auclair, A., Cussac, D., Newman‐Tancredi, A., Dekeyne, A., Nicolas, J., & Lejeune, F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00982.x · Cited by 170
Cytoarchitecture and efferent projections of the nucleus incertus of the rat
Olucha-Bordonau, F. E., Teruel‐Martí, V., Barcia‐González, J., Ruiz‐Torner, A., Valverde‐Navarro, A. A., & Martı́nez-Soriano, F. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10774 · Cited by 169
GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality
Anderberg, R. H., Richard, J. E., Hansson, C., Nissbrandt, H., Bergquist, F., & Skibicka, K. P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.021 · Cited by 170
Projections from the rhomboid nucleus of the bed nuclei of the stria terminalis: Implications for cerebral hemisphere regulation of ingestive behaviors
Dong, H., & Swanson, L. W. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10758 · Cited by 168
“…the BSTrh region is innervated by locus coeruleus noradrenergic axons (Pickel et al., 1974; Jones and Yang, 1985), dorsal raphé serotonergic axons (Vertes, 1991), and ventral tegmental area, presumably dopaminergic axons (Moore, 1978; Beckstead et al., 1979; Hökfelt et al., 1980; Hasue and…”
Background
The Role of Corticotropin-Releasing Hormone in the Dorsal Raphe Nucleus in Mediating the Behavioral Consequences of Uncontrollable Stress
Hammack, S. E., Richey, K. J., Schmid, M. J., LoPresti, M. L., Watkins, L. R., & Maier, S. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01020.2002 · Cited by 167
“, 1993), and it is the more rostral regions that project to striatum and lateral septum (Imai et al., 1986; Vertes, 1991), the regions in which extracellular 5-HT is reduced by intracerebroventricular CRH.”
Background
Dopamine–serotonin interactions in attention-deficit hyperactivity disorder (ADHD)
Oades, R. D. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00926-6 · Cited by 167
“The anatomical nature of this input differs from that deriving from the median raphe in that it is construed to be better at volume control than at advancing specific synaptic control of the target regions (Vertes, 1991; Michelsen et al., 2007).”
Background
Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus
Tanti, A., Rainer, Q., Minier, F., Surget, A., & Belzung, C. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.022 · Cited by 169
Estrogen Selectively Increases Tryptophan Hydroxylase-2 mRNA Expression in Distinct Subregions of Rat Midbrain Raphe Nucleus: Association between Gene Expression and Anxiety Behavior in the Open Field
Hiroi, R., McDevitt, R. A., & Neumaier, J. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.019 · Cited by 161
Amygdala and Extended Amygdala of the Rat: A Cytoarchitectonical, Fibroarchitectonical, and Chemoarchitectonical Survey
de Olmos, J. S., Beltramino, C. A., & Alheid, G. F. (2004) · Elsevier eBooks · doi:10.1016/b978-012547638-6/50020-1 · Cited by 160
Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
Silva, C., & McNaughton, N. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.001 · Cited by 166
“All parts receive projections from the other subdivisions, with the exception of the DLPAG column, which only receives projections from the DMPAG (Jansen et al., 1998; Vertes, 1991).”
BackgroundInfluential
Cellular Basis of Pontine Ponto-geniculo-occipital Wave Generation and Modulation
Datta, S. (1997) · Cellular and Molecular Neurobiology · doi:10.1023/a:1026398402985 · Cited by 156
“THe R-PBL also receives axonal projections from the DRN, LC, oculomotor and vestibular nuclei (Aston-Jones et al., 1986; Bobillier et al., 1976; Jones and Yang, 1985; Pierce et al., 1976; Semba Fibiger, 1992; Steininger et al., 1992; Vertes, 1991).”
Background
Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell
Li, Z., Chen, Z., Fan, G., Li, A., Yuan, J., & Xu, T. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00084 · Cited by 155
“These results appear to differ from some traditional tracing studies indicating that the striatum (the CPu and NAc) receives substantial dopaminergic (Fallon and Moore, 1978; Phillipson and Griffiths, 1985) and serotonergic innervation (Vertes, 1991; Waselus et al., 2006).”
Result
Cross-Sectional and Longitudinal Assessment of Structural Brain Alterations in Melancholic Depression
Soriano‐Mas, C., Hernández‐Ribas, R., Pujol, J., Urretavizcaya, M., Deus, J., Harrison, B. J., Ortiz, H., López‐Solà, M., Menchón, J. M., & Cardoner, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.029 · Cited by 158
The external globus pallidus: progress and perspectives
Hegeman, D. J., Hong, E. S., Hernández, V. M., & Chan, C. S. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13196 · Cited by 157
“…addition to dopaminergic inputs, the GPe receives abundant serotonergic innervation from the dorsal raphe (DeVito et al., 1980; Pasik et al., 1984; Vertes, 1991; Charara & Parent, 1994; Di Matteo et al., 2008; Bang et al., 2012; Eid et al., 2013; Ogawa et al., 2014; Pollak Dorocic et al., 2014)…”
Background
Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra
Moukhles, H., Bosler, O., Bolam, J. P., Vallée, A., Umbriaco, D., Geffard, M., & Doucet, G. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00452-6 · Cited by 151
The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness
Zhao, H., Zhang, B., Yang, S., & Rusak, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.016 · Cited by 147
An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials
Bowers, M. E., & Ressler, K. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.008 · Cited by 155
“role in PTSD - receive serotonergic input via projections from the dorsal and median raphe nucleus (17-19).”
Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits
Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Bécamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.016 · Cited by 147
“Serotonergic neurons from dorsal raphe nucleus innervate various brain areas and have been suggested to control the coordinated reorganization among different cortical regions driven by higher order cognitive functions such as attention (Geyer and Vollenweider, 2008; Vertes, 1991).”
The Dual Role of Serotonin in Defense and the Mode of Action of Antidepressants on Generalized Anxiety and Panic Disorders
Graeff, F. G., & Zangrossi, H. (2010) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524911006030207 · Cited by 145
“A similar dual action of fluoxetine has been reported in the hippocampus and has been implicated in the antidepressant effect of this SSRI [53-60].”
Background
Fos Activation of Selective Afferents to Ventral Tegmental Area during Cue-Induced Reinstatement of Cocaine Seeking in Rats
Mahler, S. V., & Aston‐Jones, G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-12.2012 · Cited by 150
“…structures within the midbrain projected moderately to strongly to VTA, as previously reported (Conrad et al., 1974; Sug- imoto and Hattori, 1984; Vertes, 1991; Cameron et al., 1995; Oakman et al., 1995; Charara et al., 1996; Gervais and Rouillard, 2000; Jhou et al., 2009a,b; Kaufling et al.,…”
Background
Collateralized dorsal raphe nucleus projections: A mechanism for the integration of diverse functions during stress
Waselus, M., Valentino, R. J., & Van Bockstaele, E. J. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.011 · Cited by 142
“…are some of the best characterized, in terms of examining a stressor that produces robust changes in multiple forebrain areas (Kirby et al., 1997) and in examining multiple forebrain areas which are innervated by at least to some extent by 5-HT projections originating in the DR (Vertes, 1991).”
Background
Classical androgen receptors in non-classical sites in the brain
Sarkey, S., Azcoitia, I., Garcia-Segura, L. M., Garcia-Ovejero, D., & DonCarlos, L. L. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.015 · Cited by 146
“…innominata (Audet, et al., 1988; Kritzer, 2003), the locus coeruleus (Fallon, et al., 1978; Saper, 1984), the dorsal raphe (Fallon et al., 1978; Vertes, 1991; Vertes, et al., 1999;Kritzer, 2003), and the ventral tegmental area (Descarries, et al., 1987; Goldsmith and Joyce, 1994; Kritzer,…”
Background
The integrated brain network that controls respiration
Krohn, F., Novello, M., van der Giessen, R. S., Zeeuw, C. I. D., Pel, J. J. M., & Bosman, L. W. J. (2023) · eLife · doi:10.7554/elife.83654 · Cited by 164
Conchlear inner hair cells exist transiently in the fetal Bronx waltzer (bv/bv) mouse
Whitlon, D. S., Gabel, C., & Zhang, X. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960115)364:3 · Cited by 30
The pedunculopontine tegmental nucleus: a role in cognitive processes?
Sleekier, T., Inglis, W. L., Winn, P., & Sahgal, A. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90016-7 · Cited by 142
Serotonin in anxiety and panic: Contributions of the elevated T-maze
Zangrossi, H., & Graeff, F. G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.007 · Cited by 139
Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas
Lanzenberger, R., Kranz, G. S., Haeusler, D., Akimova, E., Savli, M., Hahn, A., Mitterhauser, M., Spindelegger, C., Philippe, C., Fink, M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.023 · Cited by 139
“However, MRN and DRN differ in several respects, including the number, density and distribution of 5-HT containing neurons (Baker et al., 1991), autoreceptor function (Hopwood and Stamford, 2001) and their projection sites and patterns (Vertes, 1991; Vertes et al., 1999).”
BackgroundInfluential
The paraventricular nucleus of the thalamus: an integrative node underlying homeostatic behavior
Penzo, M. A., & Gao, C. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.03.001 · Cited by 138
The ascending serotonergic system in the hamster: comparison with projections of the dorsal and median raphe nuclei
Morin, L. P., & Meyer-Bernstein, E. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00585-5 · Cited by 138
Projections of the suprachiasmatic nuclei, subparaventricular zone and retrochiasmatic area in the golden hamster
Morin, L. P., Goodless-Sanchez, N., Smale, L., & Moore, R. Y. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90240-2 · Cited by 133
The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol
Lê, A. D., Harding, S., Juzytsch, W., Fletcher, P. J., & Shaham, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07844.2002 · Cited by 130
“Specifically, an anatomical framework for the present and previous findings is not readily available because the major 5-HT projection to the BNST and CeA is from the DRN (Vertes, 1991).”
Background
Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin‐releasing hormone in macaque monkeys
Hsu, D. T., & Price, J. L. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21934 · Cited by 127
The dorsal cochlear nucleus as a participant in the auditory, attentional and emotional components of tinnitus
Kaltenbach, J. A. (2006) · Hearing Research · doi:10.1016/j.heares.2006.01.002 · Cited by 129
“The dorsal raphe nucleus is a primary source of sertotonergic inputs to brain regions implicated in the pathology of depression (Imai et al., 1986; Ma et al., 1991; Vertes, 1991; Kazakov et al., 1993).”
Lateral Hypothalamic Serotonin Inhibits Nucleus Accumbens Dopamine: Implications for Sexual Satiety
Lorrain, D. S., Riolo, J. V., Matuszewich, L., & Hull, E. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07648.1999 · Cited by 129
“The LHAA receives 5-HT input from the raphe (Veening et al., 1982; Vertes, 1991) and contributes efferent fibers that ascend or descend through the medial forebrain bundle (Saper et al., 1979; Hakan et al., 1992).”
Serotonin in fear conditioning processes
Bauer, E. P. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.028 · Cited by 136
Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat
Sego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 132
“The DRC has a similar but slightly reduced set of connections with the abovecited structures and additionally receives a focal input from the LHbM (present findings) and sends massive outputs to the lateral septum (Vertes, 1991; Waselus et al., 2006) and ventricular system (Mikkelsen et al., 1997).”
BackgroundInfluential
Morphological properties of intracellularly labeled layer I neurons in rat neocortex
Zhou, F.-M., & Hablitz, J. J. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961209)376:2 · Cited by 79
Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons
Bockstaele, E. J. V., Cestari, D. M., & Pickel, V. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91330-7 · Cited by 126
Neural circuits underlying the generation of theta oscillations
Pignatelli, M., Beyeler, A., & Leinekugel, X. (2011) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2011.09.007 · Cited by 135
“The DR projects to the piriform, insular, frontal, occipital, entorhinal, perirhinal, frontal orbital, anterior cingulate, and infralimbic cortices, hippocampal formation, as well as the intralaminar nuclei of the thalamus, septal complex (in particular the lateral septum, VDB and HDB), SUM, ventral tegmental area and…”
Background
The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function
Kealy, J., & Commins, S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.03.002 · Cited by 123
“The dorsal raphe nucleus (Vertes, 1991) and the median”
BackgroundInfluential
Expression of estrogen receptors (α, β) and androgen receptor in serotonin neurons of the rat and mouse dorsal raphe nuclei; sex and species differences
Sheng, Z., Kawano, J., Yanai, A., Fujinaga, R., Tanaka, M., Watanabe, Y., & Shinoda, K. (2004) · Neuroscience Research · doi:10.1016/j.neures.2004.02.011 · Cited by 125
Thalamic neuromodulation and its implications for executive networks
Varela, C. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00069 · Cited by 129
“…The serotonergic axons innervating the thalamus have their origin in the medial and lateral divisions of the dorsal raphe (De Lima and Singer, 1987; Vertes, 1991; Gonzalo-Ruiz et al., 1995; Vertes et al., 1999, 2010; Kirifides et al., 2001), and in the median raphe (Gonzalo-Ruiz et al., 1995;…”
Background
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons
Okaty, B. W., Sturrock, N., Lozoya, Y. E., Chang, Y., Senft, R. A., Lyon, K. A., Alekseyenko, O. V., & Dymecki, S. M. (2020) · eLife · doi:10.7554/elife.55523 · Cited by 122
“…et al., 2016; O’Hearn and Molliver, 1984; Prouty et al., 2017; Ren et al., 2018; Steinbusch, 1981; Steinbusch et al., 1980; Vasudeva et al., 2011; Vertes, 1991; Vertes and Kocsis, 1994), and DR afferents have been identified from as many as eighty distinct anatomical brain regions, including…”
Background
Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors
Hervás, I., & Artigas, F. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00579-2 · Cited by 123
Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
Bonne, O. B., Grillon, C., Vythilingam, M., Neumeister, A., & Charney, D. S. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.12.001 · Cited by 128
Evidence for regional heterogeneity in corticotropin‐releasing factor interactions in the dorsal raphe nucleus
Valentino, R. J., Liouterman, L., & Bockstaele, E. J. V. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1043 · Cited by 122
“…locus coeruleus derive from caudal aspects of the DR, whereas projections to the neocortex, septum, lateral basal forebrain, ventromedial striatum, lateral hypothalamus, amygdala, and substantia nigra derive from more rostral aspects (Kohler and Steinbusch, 1982; Imai et al., 1986; Vertes, 1991).”
Background
Distinct patterns of neuronal inputs and outputs of the juxtaparaventricular and suprafornical regions of the lateral hypothalamic area in the male rat
Hahn, J. D., & Swanson, L. W. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.02.002 · Cited by 123
Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in rats
Mitsushima, D., Yamada, K. H., Takase, K., Funabashi, T., & Kimura, F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05214.x · Cited by 121
“But it is logical to consider that 5HT neurons in the DRN (Vertes, 1991), the major site that sends 5HT axons to the BLA in rats, may be sexually dimorphic and respond to the restraint stress differently in the sexes.”
Background
Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice
Ohmura, Y., Tanaka, K. F., Tsunematsu, T., Yamanaka, A., & Yoshioka, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000637 · Cited by 122
“Because the hippocampus receives projections from the caudal DRN, but not from the rostral DRN (Vertes, 1991), it is likely that we illuminated at least the caudal part of the DRN.”
Background
Neuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton, J. E., & McCormick, D. A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00650.2001 · Cited by 121
“J Neurophysiol • VOL 87 • APRIL 2002 • www.jn.org by 10.220.32.246 on A ugust 28, 2017 http://jn.physiology.org/ D ow nloaded from gic neurons in the dorsal and median raphe (Azmita and Segal 1978; Vertes 1991).”
BackgroundInfluential
Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus
Zhou, L., Liu, M., Li, Q., Deng, J., Mu, D., & Sun, Y.-G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.077 · Cited by 120
“The midbrain SN receives input from DRN serotonergic neurons (Vertes, 1991), and this input may be important to maintain the balance in the basal ganglia circuit.”
Background
Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice
Fukada, M., Hanai, A., Nakayama, A., Suzuki, T., Miyata, N., Rodriguiz, R. M., Wetsel, W. C., Yao, T., & Kawaguchi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030924 · Cited by 122
“In the present study, we provided evidence that non-histone protein acetylation plays an important role in CNS by focusing on Hdac6, a multifunctional cytoplasmic deacetylase. We demonstrated that disturbance of Hdac6-mediated protein deacetylation both by gene knockout and by chemical inhibition of deacetylase activi…”
Background
Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala
Amat, J., Tamblyn, J. P., Paul, E. D., Bland, S. T., Amat, P., Foster, A. C., Watkins, L. R., & Maier, S. F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.052 · Cited by 119
Transgene Expression in Target-Defined Neuron Populations Mediated by Retrograde Infection with Adeno-Associated Viral Vectors
Rothermel, M., Brunert, D., Zabawa, C., Díaz-Quesada, M., & Wachowiak, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1618-13.2013 · Cited by 119
“Basolateral amygdala receives relatively strong innervation from serotonergic raphe neurons (Vertes, 1991).”
Background
Chemically defined collateral projections from the pons to the central nucleus of the amygdala and hypothalamic paraventricular nucleus in the rat
Petrov, T., Krukoff, T. L., & Jhamandas, J. H. (1994) · Cell and Tissue Research · doi:10.1007/bf00327776 · Cited by 118
“The analysis of data and the location of control injections are described elsewhere ( Petrov et al. 1993 ).”
BackgroundMethodResultInfluential
Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimming
Price, M. L., Kirby, L. G., Valentino, R. J., & Lucki, I. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1114-2 · Cited by 115
“One stressor that affects the 5-HT system in a manner similar to CRF is swim stress, which decreases extracellular levels of 5-HT in the lateral septum (Kirby et al. 1995), a region that derives a dense 5-HT innervation from the DRN (Luiten et al. 1982; Vertes 1991).”
Neuronal activity in the peribrachial area: Relationship to behavioral state control
Datta, S. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00043-z · Cited by 115
Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer’s Disease Pathogenesis
Theofilas, P., Dunlop, S. R., Heinsen, H., & Grinberg, L. T. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142682 · Cited by 119
Hippocampal Formation
Cappaert, N. L. M., van Strien, N. M., & Witter, M. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-374245-2.00020-6 · Cited by 120
Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains
Alonso, A., Merchán, P., Sandoval, J. E., Sánchez-Arrones, L., Garcia-Cazorla, A., Artuch, R., Ferrán, J. L., Martínez-de-la-Torre, M., & Puelles, L. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0456-8 · Cited by 113
“…nigra, caudate/putamen—while the r1DR neurons project to limbic system formations—hippocampus, locus coeruleus—(Fuxe et al. 1977; Köhler and Steinbusch 1982; O’Hearn and Molliver 1984; Imai et al. 1986; Mamounas et al. 1991; Vertes 1991; Jacobs and Azmitia 1992; Waselus et al. 2006).”
Background
The dorsal raphe nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses
Cheeta, S., Irvine, E. E., Kenny, P. J., & File, S. E. (2001) · Psychopharmacology · doi:10.1007/s002130100681 · Cited by 113
“The 5-HT projections to the lateral septum arise from the dorsal raphe nucleus (DRN; Anderson et al. 1983; Vertes 1991 ), and earlier research has demonstrated that direct administration of the specific 5-HT 1A receptor agonist 8-OH-DPAT into the DRN induces an anxiolytic”
Background
Quantitative autoradiographic characterisation of the binding of [3H]WAY-100635, a selective 5-HT1A receptor antagonist
Khawaja, X. Z. (1995) · Brain Research · doi:10.1016/0006-8993(94)01416-f · Cited by 113
Functional connectivity of the dorsal and median raphe nuclei at rest
Beliveau, V., Svarer, C., Frøkjær, V. G., Knudsen, G. M., Greve, D. N., & Fisher, P. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.065 · Cited by 113
“Structural evidence supports the presence of direct reciprocal projections betweenmPFC and raphe (Behzadi et al., 1990; Peyron et al., 1998; Vertes and Linley, 2008; Vertes, 1991) and direct stimulation of mPFC has been shown to modulate raphe 5-HT neuron activity (Hajós et al.”
Background
Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect
Shishkina, G. T., Kalinina, T. S., & Дыгало, Н. Н. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.017 · Cited by 112
Localization of 5-ht5A receptor-like immunoreactivity in the rat brain
Oliver, K. R., Kinsey, A. M., Wainwright, A., & SIRINATHSINGHJI, D. J. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02273-3 · Cited by 109
Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra
Gervais, J., & Rouillard, C. (2000) · Synapse · doi:10.1002/(sici)1098-2396(20000315)35:4 · Cited by 109
Alleviation of depression by glucagon-like peptide 1 through the regulation of Neuroinflammation, neurotransmitters, neurogenesis, and synaptic function
Kim, Y.-K., Kim, O. Y., & Song, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01270 · Cited by 109
“These neurons innervate the amygdala (Vertes, 1991) and the hippocampus (McQuade and Sharp, 1997).”
Background
Electrophysiological diversity of the dorsal raphe cells across the sleep–wake cycle of the rat
Urbain, N., Creamer, K., & Debonnel, G. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108514 · Cited by 108
“Email: nadia.urbain@crulrg.ulaval.ca Dorsal raphe nucleus (DRN) neurons project to widespread regions of the forebrain (Azmitia & Segal, 1978; Vertes, 1991), thus influencing many different brain structures.”
Background
High-Frequency Stimulation of the Subthalamic Nucleus and l-3,4-Dihydroxyphenylalanine InhibitIn VivoSerotonin Release in the Prefrontal Cortex and Hippocampus in a Rat Model of Parkinson's Disease
Navailles, S., Benazzouz, A., Bioulac, B. H., Gross, C. E., & Deurwaerdère, P. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5031-09.2010 · Cited by 106
“The prefrontal cortex (PFC) and the hippocampus (HIPP) are two brain regions involved in the regulation of mood and cognition (Vertes, 2006; Drevets et al., 2008) that receive distinct serotonergic innervation from the dorsal raphe nucleus (DRN) and/or median raphe nucleus (MRN) (Molliver, 1987; Vertes, 1991).”
BackgroundInfluential
RDoC-based categorization of amygdala functions and its implications in autism
Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 107
Anxiogenic effects in the rat elevated plus-maze of 5-HT2C agonists into ventral but not dorsal hippocampus
Alves, S. H. D. S., Pinheiro, G. D. A., Motta, V., Landeira-Fernández, J., & Cruz, A. P. D. M. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200402000-00005 · Cited by 106
“The role of VH 5-HT2C receptors in the modulation of anxiety states might involve 5-HT projections from the DRN (Azmitia and Segal, 1978; Vertes, 1991).”
Background
Afferent connections of the interstitial nucleus of the posterior limb of the anterior commissure and adjacent amygdalostriatal transition area in the rat
Shammah‐Lagnado, S. J., Alheid, G. F., & Heimer, L. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)90280-4 · Cited by 106
The effect of the selective 5‐HT1A agonists alnespirone (S‐20499) and 8‐OH‐DPAT on extracellular 5‐hydroxytryptamine in different regions of rat brain
Casanovas, J. M., Lesourd, M., & Artigas, F. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701420 · Cited by 104
“…structures by neurones of these two nuclei (Jacobs et al., 1974; Lorens & Guldberg, 1974; Bobilier et al., 1975; Moore & Halaris, 1975; Azmitia & Segal, 1978; KoÈ hler & Steinbusch, 1982; Imai et al., 1986; Kosofsky & Molliver, 1987; Mamounas & Molliver, 1988; Vertes, 1991; McQuade & Sharp, 1997).”
Background
Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus
Hensler, J. G., Ferry, R. C., Kovachich, G. B., & Frazer, A. (1994) · Synapse · doi:10.1002/syn.890170102 · Cited by 104
Maternal separation and social isolation modulate the postnatal development of synaptic composition in the infralimbic cortex of Octodon degus
Ovtscharoff, W. A., & Braun, K. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00059-8 · Cited by 103
The role of the dorsal raphé nucleus in reward-seeking behavior
Nakamura, K. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00060 · Cited by 114
“Fourth, an increase of 5-HT may regulate the processing of stress via the activation of pituitary and adrenal functions (Vernikos-Danellis et al., 1977), which have bi-directional interactions with the 5-HT system.”
Background
Amphetamine Depresses Excitatory Synaptic Transmission via Serotonin Receptors in the Ventral Tegmental Area
Jones, S., & Kauer, J. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09780.1999 · Cited by 102
“Psychostimulants can also increase extracellular serotonin levels by binding to the serotonin transporter present on serotonergic terminals originating in the raphe nucleus (Ritz et al., 1987; Vertes, 1991), and there is growing evidence for an involvement of serotonin systems in drug addiction.”
Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits
Burghardt, N. S., & Bauer, E. P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.050 · Cited by 109
Ultrastructure and synaptic targets of the raphe-nigral projection in the rat
Corvaja, N., Doucet, G., & Bolam, J. P. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90510-m · Cited by 101
Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice
Ait-Bali, Y., Ba-M’hamed, S., & Bennis, M. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00146 · Cited by 98
“It is well established that several neuronal systems, in particular the serotoninergic system innervating cortical and limbic brain structures, are involved in the pathophysiology of anxiety and depression related behaviors (Azmitia and Segal, 1978; Vertes, 1991).”
Background
Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders
Broncel, A., Bocian, R., Kłos‐Wojtczak, P., Kulbat-Warycha, K., & Konopacki, J. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.11.011 · Cited by 102
“…systems (Assaf and Miller, 1978; Loy et al., 1980; Scatton et al., 1980; Verney et al., 1985; Vanderwolf and Baker, 1986; Fibiger, 1991; Vertes, 1991; Mizumori et al., 1992; Markowska et al., 1995; Squire and Alvarez, 1995; Gasbarri et al., 1997; Vertes et al., 1999; King et al., 2002;…”
Background
Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons
Ito, H., Yanase, M., Yamashita, A., Kitabatake, C., Hamada, A., Suhara, Y., Narita, M., Ikegami, D., Sakai, H., Yamazaki, M., et al. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-59 · Cited by 98
“Neurons from the DRN provide a substantial proportion of the 5-HT innervation to the forebrain through their widespread projections [28].”
Background
Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the rat
Kirifides, M. L., Simpson, K. L., Lin, R. C. S., & Waterhouse, B. D. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1033 · Cited by 97
“…the neocortex, thalamus, hippocampus, tectum, and cerebellum of the mammalian brain (Bjorklund et al., 1971; Ungerstedt, 1971; Shinnar et al., 1973; Conrad et al., 1974; Azmitia and Segal, 1978; Moore et al., 1978; Steinbusch, 1981; Kerr and Bishop, 1991; Vertes, 1991; Jacobs and Azmitia, 1992).”
Background
Neural affective decision theory: Choices, brains, and emotions
Litt, A., Eliasmith, C., & Thagard, P. R. (2008) · Cognitive Systems Research · doi:10.1016/j.cogsys.2007.11.001 · Cited by 96
“This is supported by a variety of experimental studies in humans and other animals (Deakin, 1983; Evenden & Ryan, 1996; Mobini, Chiang, Ho, Bradshaw, & Szabadi, 2000; Soubrié, 1986; Vertes, 1991; for a review, see Daw et al., 2002).”
Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model
Zhang, H., Zhao, H., Zeng, C., Dort, C. J. V., Faingold, C. L., Taylor, N. E., Solt, K., & Feng, H.-J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.11.003 · Cited by 96
Regulation of Energy Expenditure by Brainstem GABA Neurons
Schneeberger, M., Parolari, L., Banerjee, T. D., Bhave, V. M., Wang, P., Patel, B., Topilko, T., Wu, Z., Choi, C. H. J., Yu, X., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.048 · Cited by 99
“mapped the ascending (Vertes, 1991) and brainstem (Vertes and Kocsis, 1994) projections of the DRN overall, cell-type-specific outputs have not been fully characterized.”
Background
Reelin expression during embryonic brain development in lacertilian lizards
Goffinet, A. M., Bar, I., Bernier, B., Trujillo, C. M., Raynaud, A., & Meyer, G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991129)414:4 · Cited by 62
Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat
Lüttgen, M., Elvander-Tottie, E., Madjid, N., & Ögren, S. O. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.007 · Cited by 96
Limbic Thalamus: Structure, Intrinsic Organization, and Connections
Bentivoglio, M., Kultas‐Ilinsky, K., & Ilinsky, I. A. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6704-6_3 · Cited by 96
Effects of acute and chronic fluoxetine treatments on restraint stress-induced Fos expression
de Oliveira, C. L., Sales, A. J., Bel, E. A. D., Silveira, M. C. L., & Guimarães, F. S. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00566-4 · Cited by 95
Possible glutamatergic/aspartatergic projections to the supramammillary nucleus and their origins in the rat studied by selective [3H]D-aspartate labelling and immunocytochemistry
Kiss, J., Csáki, Á., Bokor, H., Kocsis, K., & Kocsis, B. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00037-4 · Cited by 91
Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease
Dong, J., Hawes, S., Wu, J., Le, W., & Cai, H. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.645287 · Cited by 93
“DRN axons project to almost all the BG nuclei (Vertes, 1991) and GPe is no exception.”
Background
Origin of projections from the midbrain raphe nuclei to the hypothalamic paraventricular nucleus in the rat: A combined retrograde and anterograde tracing study
Larsen, P. J., Hay‐Schmidt, A., Vrang, N., & Mikkelsen, J. D. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00415-7 · Cited by 94
Interactions of (+)- and (−)-8- and 7-Hydroxy-2-(Di-n-Propylamino)tetralin at Human (h)D3, hD2 and h Serotonin1A Receptors and Their Modulation of the Activity of Serotoninergic and Dopaminergic Neurones in Rats
Lejeune, F., Newman‐Tancredi, A., Audinot, V., & Millan, M. J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36532-2 · Cited by 94
Serotonergic and nonserotonergic neurons in the dorsal raphe nucleus send collateralized projections to both the vestibular nuclei and the central amygdaloid nucleus
Halberstadt, A. L., & Balaban, C. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.053 · Cited by 93
Immunostaining for substance P receptor labels GABAergic cells with distinct termination patterns in the hippocampus
Acsády, L., Katona, I., Gulyás, A. I., Shigemoto, R., & Freund, T. F. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970217)378:3 · Cited by 63

Authors: Vertes, R. P.
Affiliations: Florida Atlantic University (US)
Corresponding author: Vertes, Robert P.
ORCID: Vertes, Robert P.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1991-11-22
Volume: 313
Issue: 4
Pages: 643-668
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903130409
OpenAlex: W1984112731
Cited by: 842
References: 138
Citations by year: 2026: 12 · 2025: 16 · 2024: 17 · 2023: 20 · 2022: 17 · 2021: 28 · 2020: 27 · 2019: 26 · 2018: 25 · 2017: 32 · 2016: 31 · 2015: 36 · 2014: 36 · 2013: 29 · 2012: 32
FWCI: 4.18
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4705 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dorsal raphe nucleus, ascending projections, serotonergic system, medial forebrain bundle, thalamus, amygdala, striatum, hippocampal formation, anterograde tracing, Phaseolus vulgaris leucoagglutinin, periaqueductal gray, substantia nigra pars compacta, ventral tegmental area
MeSH terms: Animals, Cerebral Cortex, Hippocampus, Immunohistochemistry, Male, Neural Pathways, Phytohemagglutinins, Raphe Nuclei, Rats, Inbred Strains, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks