Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin‐releasing hormone in macaque monkeys

Hsu, David T.; Price, Joseph L.

doi:10.1002/cne.21934

Cited by 127Stress Responses and CortisolSleep and Wakefulness ResearchNeurotransmitter Receptor Influence on Behavior

Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin‐releasing hormone in macaque monkeys

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Hsu, David T., Price, Joseph L.·2009·Journal of Comparative Neurology

DOI 10.1002/cne.21934PMC PMC2646254

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Abstract

The present study examines subcortical connections of paraventricular thalamic nucleus (Pa) following small anterograde and retrograde tracer injections in cynomolgus monkeys (Macaca fascicularis). An anterograde tracer injection into the dorsal midline thalamus revealed strong projections to the accumbens nucleus, basal amygdala, lateral septum, and hypothalamus. Retrograde tracer injections into these areas labeled neurons specifically in Pa. Following a retrograde tracer injection into Pa, labeled neurons were found in the hypothalamus, dorsal raphe, and periaqueductal gray. Pa contained a remarkably high density of axons and axonal varicosities immunoreactive for serotonin (5‐HT) and orexin/hypocretin (ORX), as well as a moderate density of fibers immunoreactive for corticotropin‐releasing hormone (CRH). A retrograde tracer injection into Pa combined with immunohistochemistry demonstrated that ORX and 5‐HT axons originate from neurons in the hypothalamus and midbrain. Pa‐projecting neurons were localized in the same nuclei of the hypothalamus, amygdala, and midbrain as CRH neurons, although no double labeling was found. The connections of Pa and its innervation by 5‐HT, ORX, and CRH suggest that it may relay stress signals between the midbrain and hypothalamus with the accumbens nucleus, basal amygdala, and subgenual cortex as part of a circuit that manages stress and possibly stress‐related psychopathologies. J. Comp. Neurol. 512:825–848, 2009. © 2008 Wiley‐Liss, Inc.

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Many hypothalamic and brainstem inputs to the PVT utilize specific transmitters, including corticosteroid releasing hormone, orexin, serotonin, and norepinephrine.
“Many of the hypothalamic and brainstem inputs to the PVT utilize specific transmitters, including corticosteroid releasing hormone, orexin, serotonin, and norepinephrine (Hsu and Price, 2009).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Hsu and Price, 2009

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(1996) · doi:10.1002/(sici)1096-9861(19960219)365:4

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Jones EG The Thalamus 2007 Cambridge University Press New York 2nd Ed.
Öngür D An X Price JL Prefrontal cortical projections to the hypothalamus in macaque monkeys J Comp Neurol 1998 401 480 505 9826274

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Authors: Hsu, D. T., & Price, J. L.
Affiliations: University of Michigan (US)
Washington University in St. Louis (US)
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2008-12-10
Volume: 512
Issue: 6
Pages: 825-848
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.21934
PMC: PMC2646254
OpenAlex: W2013679333
Cited by: 127
References: 128
Citations by year: 2026: 1 · 2025: 4 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 13 · 2013: 4 · 2012: 10
FWCI: 4.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Deep Blue (University of Michigan) (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (MH070941, MH068148, F32MH068148, R01MH070941)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: paraventricular thalamus, serotonin, orexin, corticotropin-releasing factor, subcortical connections, nucleus accumbens, basal amygdala, lateral septum, hypothalamus, dorsal raphe nucleus, periaqueductal gray, stress signaling, stress-related psychopathology, Macaca fascicularis
MeSH terms: Orexins, Animals, Corticotropin-Releasing Hormone, Humans, Macaca fascicularis, Neural Pathways, Neuropeptides, Serotonin, Midline Thalamic Nuclei, Intracellular Signaling Peptides and Proteins

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Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin‐releasing hormone in macaque monkeys

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