Collateralized dorsal raphe nucleus projections: A mechanism for the integration of diverse functions during stress

Waselus, Maria; Valentino, Rita J.; Van Bockstaele, Elisabeth J.

doi:10.1016/j.jchemneu.2011.05.011

Cited by 142Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Collateralized dorsal raphe nucleus projections: A mechanism for the integration of diverse functions during stress

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Waselus, Maria, Valentino, Rita J., Van Bockstaele, Elisabeth J.·2011·Journal of Chemical Neuroanatomy

DOI 10.1016/j.jchemneu.2011.05.011PMC PMC3156417

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Abstract

The midbrain dorsal raphe nucleus (DR) is the origin of the central serotonin (5-HT) system, a key neurotransmitter system that has been implicated in the expression of normal behaviors and in diverse psychiatric disorders, particularly affective disorders such as depression and anxiety. One link between the DR-5-HT system and affective disorders is exposure to stressors. Stress is a major risk factor for affective disorders, and stressors alter activity of DR neurons in an anatomically specific manner. Stress-induced changes in DR neuronal activity are transmitted to targets of the DR via ascending serotonergic projections, many of which collateralize to innervate multiple brain regions. Indeed, the collateralization of DR efferents allows for the coordination of diverse components of the stress response. This review will summarize our current understanding of the organization of the ascending DR system and its collateral projections. Using the neuropeptide corticotropin-releasing factor (CRF) system as an example of a stress-related initiator of DR activity, we will discuss how topographic specificity of afferent regulation of ascending DR circuits serves to coordinate activity in functionally diverse target regions under appropriate conditions.

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Based on retrograde tracing, DR subregions may preferentially project to different targets.
“Based on retrograde tracing DR subregions may preferentially project to different targets (reviewed in Waselus et al., 2011).”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Waselus et al., 2011

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Authors: Waselus, M., Valentino, R. J., & Van Bockstaele, E. J.
Affiliations: University of Michigan (US)
Children's Hospital of Philadelphia (US)
Corresponding author: Waselus, Maria
ORCID: Waselus, Maria
Valentino, Rita J.
Venue: Journal of Chemical Neuroanatomy
Publisher: Elsevier BV
Published: 2011-07
Volume: 41
Issue: 4
Pages: 266-280
ISSN: 0891-0618 (ISSN-L)
DOI: 10.1016/j.jchemneu.2011.05.011
PMC: PMC3156417
OpenAlex: W2049613345
Cited by: 142
References: 177
Citations by year: 2026: 7 · 2025: 13 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 13 · 2013: 13 · 2012: 12
FWCI: 1.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Chemical Neuroanatomy (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH-02006, MH58250, R01MH058250, R56MH058250, K05MH002006)
National Institute on Drug Abuse (R01DA009082, DA 09082)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dorsal raphe nucleus, serotonergic system, collateral projections, stress response, corticotropin-releasing factor, mood disorders, depression, anxiety
MeSH terms: Afferent Pathways, Animals, Anxiety, Corticotropin-Releasing Hormone, Depression, Humans, Synaptic Transmission, Neurons, Raphe Nuclei, Serotonin, Receptors, Corticotropin-Releasing Hormone, Substance-Related Disorders, Rats

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Collateralized dorsal raphe nucleus projections: A mechanism for the integration of diverse functions during stress

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