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Cited by 188Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study

Mesulam, M.‐Marsel, Hersh, Louis B., Mash, Deborah C., Geula, Changiz·1992·Journal of Comparative Neurology
DOI 10.1002/cne.903180308
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Abstract

The distribution of cholinergic fibers in the human brain was investigated with choline acetyltransferase immunocytochemistry in 35 cytoarchitectonic subdivisions of the cerebral cortex. All cortical areas and all cell layers contained cholinergic axons. These fibers displayed numerous varicosities and, on occasion, complex preterminal profiles arranged in the form of dense clusters. The density of cholinergic axons tended to be higher in the more superficial layers of the cerebral cortex. Several distinct patterns of lamination were identified. There were also major differences in the overall density of cholinergic axons from one cytoarchitectonic area to another. The cholinergic innervation of primary sensory, unimodal, and heteromodal association areas was lighter than that of paralimbic and limbic areas. Within unimodal association areas, the density of cholinergic axons and varicosities was significantly lower in the upstream (parasensory) sectors than in the downstream sectors. Within paralimbic regions, the non‐isocortical sectors had a higher density of cholinergic innervation than the isocortical sectors. The highest density of cholinergic axons was encountered in core limbic structures such as the hippocampus and amygdala. These observations show that the cholinergic innervation of the human cerebral cortex displays regional variations that closely follow the organization of information processing systems.

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Crossref · 10.1002/cne.903180308

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Citations

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Show all 42 references

Research works printed but not linked: 4

  1. Geula C., 1990, Human brain cortical cholinergic innervation, Soc. Neurosci. Abstr., 16, 1057
  2. Kitt C. A., 1988, Immunocytochemical visualization of cholinergic fibers in monkey neocortex using silver nitrate, Soc Neurosci. Abstr., 14, 631
  3. Lim C., 1991, Cortical cholinergic fibers in the human brain: and immunocytochemical study of the hypocampal formation, Soc. Neurosci. Abstr., 17, 1164
  4. Umbriaco D., 1990, Ultrastructural features of acetylcholine axon terminals in adult rat cerebral cortex, Soc. Neurosci. Abstr., 16, 1057

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Metadata

Authors
Mesulam, M. ‐., Hersh, L. B., Mash, D. C., & Geula, C.
Affiliations
  • Harvard University (US)
  • University of Texas Health Science Center at Dallas (US)
  • University of Miami (US)
Corresponding author
Mesulam, M.‐Marsel
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1992-04-15
Volume
318
Issue
3
Pages
316-328
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903180308
OpenAlex
W2076151759
Cited by
188
References
42
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 3 · 2014: 10 · 2013: 9 · 2012: 7
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4560 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ns025785-05, 5r01ns020285-15)
  • National Institute on Aging (P50AG005134, AG 05134)
  • National Institute of Neurological Disorders and Stroke (NS 25785, NS 20285)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
cholinergic innervation, cerebral cortex, choline acetyltransferase, cholinergic axons, varicosities, cortical lamination, cytoarchitectonic areas, association cortex, limbic system, hippocampus, amygdala
MeSH terms
Adult, Axons, Cerebral Cortex, Choline O-Acetyltransferase, Cholinergic Fibers, Humans, Immunohistochemistry, Male, Middle Aged, Neutral Red, Oxazines, Parasympathetic Nervous System, Staining and Labeling, Benzoxazines

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