Plasticity of auditory cortex associated with sensorineural hearing loss in adult C57BL/6J mice
Abstract
The representation of frequency was mapped in the primary auditory cortex (AI) of C57BL/6J (C57) mice during young adulthood (1.5-2 months) when hearing is optimal, and at 3, 6, and 12 months of age, a period during which progressive, high frequency, sensorineural hearing loss occurs in this strain. Maps were also obtained from CBA/CaJ mice which retain good hearing as they age. In AI of young adult C57 mice and CBA mice, characteristic frequencies (CFs) of multiple-unit clusters were easily identified with extracellular recordings, and a general tonotopic organization was observed from dorsal (high frequency) to ventral and caudal (low frequency). In individual cases there appeared to be deviations from the above tonotopic organization, despite the fact that inbred mice are genetically invariant. As progressive loss of high frequency sensitivity ensued peripherally, a substantially increased representation of middle frequencies was observed in AI. There was no apparent change in the surface area of the auditory cortex despite the elimination of high frequencies, and virtually the entire auditory cortex became devoted to the middle frequencies (especially 10-13 kHz) for which sensitivity remained high. Similar age-related changes were not observed in normal-hearing CBA mice. These findings indicate that plasticity in the representation of frequency in AI is associated with high frequency hearing loss in C57 mice.
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There is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain.
“As there is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain [46–50]”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [49]
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- Authors
- Willott, J. F., Aitkin, L. M., & McFadden, S. L.
- Affiliations
- Northern Illinois University (US)
- Monash University (AU)
- ORCID
- McFadden, Sandra L.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1993-03-15
- Volume
- 329
- Issue
- 3
- Pages
- 402-411
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2053858196
- Cited by
- 181
- References
- 26
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 8 · 2012: 7
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (1R37 AG07554, R37AG007554)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- auditory cortex, sensorineural hearing loss, tonotopic organization, cortical plasticity, C57BL/6J mice, CBA/CaJ mice, age-related hearing loss, characteristic frequency, spectral representation, high-frequency sensitivity
- MeSH terms
- Acoustic Stimulation, Aging, Animals, Auditory Cortex, Brain Mapping, Female, Hearing Loss, Sensorineural, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Neuronal Plasticity, Evoked Potentials, Auditory, Brain Stem, Mice
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