Parvalbumin immunoreactivity in the auditory cortex of a mouse model of presbycusis.
Abstract
Age-related hearing loss (presbycusis) affects ∼35% of humans older than sixty-five years. Symptoms of presbycusis include impaired discrimination of sounds with fast temporal features, such as those present in speech. Such symptoms likely arise because of central auditory system plasticity, but the underlying components are incompletely characterized. The rapid spiking inhibitory interneurons that co-express the calcium binding protein Parvalbumin (PV) are involved in shaping neural responses to fast spectrotemporal modulations. Here, we examined cortical PV expression in the C57bl/6 (C57) mouse, a strain commonly studied as a presbycusis model. We examined if PV expression showed auditory cortical field- and layer-specific susceptibilities with age. The percentage of PV-expressing cells relative to Nissl-stained cells was counted in the anterior auditory field (AAF) and primary auditory cortex (A1) in three age groups: young (1-2 months), middle-aged (6-8 months) and old (14-20 months). There were significant declines in the percentage of cells expressing PV at a detectable level in layers I-IV of both A1 and AAF in the old mice compared to young mice. In layers V-VI, there was an increase in the percentage of PV-expressing cells in the AAF of the old group. There were no changes in percentage of PV-expressing cells in layers V-VI of A1. These data suggest cortical layer(s)- and field-specific susceptibility of PV+ cells with presbycusis. The results are consistent with the hypothesis that a decline in inhibitory neurotransmission, particularly in the superficial cortical layers, occurs with presbycusis.
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Reduced GABAergic signaling has been demonstrated in the aged auditory system of rodents and humans.
“several studies have demonstrated reduced GABAergic signaling in the aged auditory system of rodents and humans (Caspary et al., 1990; Ouda et al., 2008; Martin del Campo et al., 2012; Gao et al., 2015).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Martin del Campo et al., 2012
Auditory cortex was identified using hippocampal landmarks, a method previously validated using tonotopic mapping and dye injection.
“Auditory cortex was identified using hippocampal landmarks.This method has been previously validated using tonotopic mapping and dye injection (Martin del Campo et al. 2012) and comparison with the Paxinos mouse atlas and other publications on mouse auditory cortex (Anderson et al. 2009).”
From Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice (2018) · cites this paper as Martin del Campo et al. 2012
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- Authors
- Martin del Campo, H. N., Measor, K. R., & Razak, K. A.
- Affiliations
- University of California, Riverside (US)
- Corresponding author
- Razak, K.A.
- ORCID
- Razak, K.A.
- Venue
- Hearing Research
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 294
- Issue
- 1-2
- Pages
- 31-39
- ISSN
- 0378-5955 (ISSN-L)
- OpenAlex
- W2041765814
- Cited by
- 76
- References
- 59
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hearing Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Riverside
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- parvalbumin, age-related hearing loss, auditory cortex, inhibitory interneurons, cortical layers, anterior auditory field, primary auditory cortex, inhibitory neurotransmission, C57BL/6 mice
- MeSH terms
- Acoustic Stimulation, Aged, Aging, Animals, Auditory Cortex, Disease Models, Animal, Female, Humans, Immunohistochemistry, Interneurons, Male, Mice, Inbred C57BL, Synaptic Transmission, Parvalbumins, Presbycusis, Evoked Potentials, Auditory, Brain Stem, Mice
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