Analgesic and decongestant efficacy of the combination of aspirin with pseudoephedrine in patients with symptoms of upper respiratory tract infection
Open accessAbstract
The study investigated the efficacy and safety of a combination therapy of 1,000 mg aspirin (ASA) and 60 mg pseudoephedrine (PSE) on the symptoms of pain (combined score for headache and sore throat) and nasal congestion in 833 patients with acute upper respiratory tract viral infection (URTI), over 4 hours after a single dose in the clinic and over 3 days with multiple doses at home. The study demonstrated that over 4 hours in the clinic the combination ASA plus PSE was superior to PSE or placebo for relief of pain symptoms measured subjectively with pain scores, and was superior to ASA or placebo for relief of nasal congestion as measured objectively with rhinomanometry and subjectively with congestion scores. After 3 days of treatment, ASA plus PSE was superior to PSE but not to placebo or ASA for global pain assessments, and ASA plus PSE was superior to ASA and placebo but not to PSE for congestion assessments. No unexpected adverse events occurred and no serious adverse events were attributed to study medicines. This study demonstrates that a combination therapy of ASA plus PSE provides safe and effective relief of both common cold pain related symptoms and nasal congestion.
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In Eccles 2014, the sum of nasal congestion differences over three days was significantly higher with the combination than with acetylsalicylic acid (P = 0.016).
“This was also the case when compared to acetylsalicylic acid (P = 0.016).”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Eccles 2014
In Results > Efficacy, Table 1 reports that the three-day sum of subjective nasal congestion intensity differences was not significant for the combination versus ASA (P = 0.969). The P = 0.016 result instead applies to total subjective nasal congestion relief over three days. (LLM, conf=0.89)
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Experimental — accuracy not yet measuredIn Eccles 2014, the sum of nasal congestion differences over three days was significantly higher with the combination therapy (pseudoephedrine + acetylsalicylic acid) than with placebo (P = 0.048).
“In Eccles 2014, the sum of nasal congestion differences over three days was significantly higher with the combination therapy (pseudoephedrine + acetylsalicylic acid) than with placebo (P = 0.048).”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Eccles 2014
In Eccles 2014, there was no significant difference between the combination and pseudoephedrine (P = 0.371).
“When compared to pseudoephedrine there was no significant difference (P = 0.371).”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Eccles 2014
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Cites
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Nasal decongestants in monotherapy for the common cold
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Pharmacology in Upper Airway Physiology
Spadaro, S., & Çelik, G. Ş. (2023) · Springer eBooks · doi:10.1007/978-3-031-32487-1_23
- Authors
- Eccles, R., & Voelker, M.
- Affiliations
- Cardiff University (GB)
- Bayer Consumer Care Morristown NJ USA
- Corresponding author
- Eccles, Ronald
- ORCID
- Eccles, Ronald
- Venue
- Clinical Pharmacology in Drug Development
- Publisher
- Wiley
- Published
- 2013-08-20
- Volume
- 3
- Issue
- 2
- Pages
- 118-125
- ISSN
- 2160-763X (ISSN-L)
- 2160-7648
- PMC
- PMC4467259
- OpenAlex
- W1548577492
- Cited by
- 12
- References
- 16
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Pharmacology in Drug Development (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Funders
- Bayer HealthCare LLC
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Herbal Medicine Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- aspirin, pseudoephedrine, analgesic combination, upper respiratory tract infection, common cold, headache, sore throat, nasal congestion, rhinomanometry, analgesia, drug safety
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