Editorial Comment: The Host Response, Not the Virus, Causes the Symptoms of the Common Cold
Abstract
J. Owen Hendley; Editorial Comment: The Host Response, Not the Virus, Causes the Symptoms of the Common Cold, Clinical Infectious Diseases, Volume 26, Issu
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In the common cold, the typical signs and symptoms of illness are primarily caused by the release of the proinflammatory cytokines produced in response to infection.
“In the common cold, the typical signs and symptoms of illness are primarily caused by the release of the proinflammatory cytokines produced in response to infection (13).”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [13]
Proinflammatory cytokines are thought to both up-regulate immunity to the virus and produce cold symptoms.
“Parodoxically, proinflammatory cytokines are thought to both up-regulate immunity to the virus and produce cold symptoms (13).”
From Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk (2012) · cites this paper as [13]
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Self-citation
- Authors
- Hendley, J. O.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Hendley, J. Owen
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-04
- Volume
- 26
- Issue
- 4
- Pages
- 847-848
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2165392794
- Cited by
- 56
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2019: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- common cold, host response, viral symptoms, rhinovirus, host-virus interaction
- MeSH terms
- Common Cold, Humans, Rhinovirus
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