The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Drug‐Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles
Abstract
Some patients prescribed flucloxacillin (~ 0.01%) develop drug‐induced liver injury ( DILI ). HLA ‐B*57:01 is an established genetic risk factor for flucloxacillin DILI . To consolidate this finding, identify additional genetic factors, and assess relevance of risk factors for flucloxacillin DILI in relation to DILI due to other penicillins, we performed a genomewide association study involving 197 flucloxacillin DILI cases and 6,835 controls. We imputed single‐nucleotide polymorphism and human leukocyte antigen (HLA) genotypes. HLA ‐B*57:01 was the major risk factor (allelic odds ratio ( OR ) = 36.62; P = 2.67 × 10 −97 ). HLA ‐B*57:03 also showed an association ( OR = 79.21; P = 1.2 × 10 −6 ). Within the HLA ‐B protein sequence, imputation showed valine 97 , common to HLA ‐B*57:01 and HLA ‐B*57:03, had the largest effect ( OR = 38.1; P = 9.7 × 10 −97 ). We found no HLA ‐B*57 association with DILI due to other isoxazolyl penicillins ( n = 6) or amoxicillin ( n = 15) and no significant non‐ HLA signals for any penicillin‐related DILI .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“HLA polymorphisms shown to be significantly associated with multiple drugs include HLA-A*02:01 for AC and cefazolin DILI and HLA-B*35:01 for multiple HDS products, including green tea extract, turmeric, and Polygonum multiform.”
From The contemporary epidemiology, causes, and management of drug-induced liver injury (2026) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,684
Genes mirror geography within Europe
Novembre, J., Johnson, T., Bryc, K., Kutalik, Z., Boyko, A. R., Auton, A., Indap, A., King, K. S., Bergmann, S., Nelson, M. R., et al. (2008) · Nature · doi:10.1038/nature07331 · Cited by 1,479
Self-citationHLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
Hung, S.-I., Chung, W.-H., Liou, L.-B., Chu, C.-C., Lin, M., Huang, H.-P., Lin, Y.-L., Lan, J.-L., Yang, L.-C., Hong, H.-S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409500102 · Cited by 1,284
Case definition and phenotype standardization in drug-induced liver injury
Aithal, G. P., Watkins, P. B., Andrade, R. J., Larrey, D., Molokhia, M., Takikawa, H., Hunt, C. M., Wilke, R. A., Avigan, M., Kaplowitz, N., et al. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.58 · Cited by 944
Self-citationHLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
study, F. T. D., Daly, A. K., International SAE Consortium, Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe'er, I., Floratos, A., Daly, M. J., Goldstein, D. B., et al. (2009) · Nature Genetics · doi:10.1038/ng.379 · Cited by 944
Self-citationHLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperavičiūtė, D., Carrington, M., Sills, G. J., Marson, T., Jia, X., de Bakker, P. I. W., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1013297 · Cited by 925
Self-citationImmune self-reactivity triggered by drug-modified HLA-peptide repertoire
Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., et al. (2012) · Nature · doi:10.1038/nature11147 · Cited by 696
Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
Jia, X., Han, B., Onengut-Gumuscu, S., Chen, W.-M., Concannon, P. J., Rich, S. S., Raychaudhuri, S., & de Bakker, P. I. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064683 · Cited by 645
Benichou, C., Danan, G., & Flahault, A. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90102-7 · Cited by 491
HIBAG—HLA genotype imputation with attribute bagging
Zheng, X., Shen, J., Cox, C., Wakefield, J. C., Ehm, M. G., Nelson, M. R., & Weir, B. S. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.18 · Cited by 424
Self-citation
Cited by
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Fontana, R. J., Liou, I., Reuben, A., Suzuki, A., Fiel, M. I., Lee, W., & Navarro, V. (2023) · Hepatology · doi:10.1002/hep.32689 · Cited by 340
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, A., Di Zeo-Sánchez, D. E., López-Gómez, C., Pérez-Valdés, Z., García-Fuentes, E., Andrade, R. J., Lucena, M. I., & Villanueva-Paz, M. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.013 · Cited by 70
Self-citationTeschke, R. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00730 · Cited by 62
Nicoletti, P., Dellinger, A., Li, Y. J., Barnhart, H. X., Chalasani, N., Fontana, R. J., Odin, J. A., Serrano, J., Stolz, A., Etheridge, A. S., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2022.11.036 · Cited by 50
Self-citationGenetic risk factors in the development of idiosyncratic drug-induced liver injury
Stephens, C., Lucena, M. I., & Andrade, R. J. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1854726 · Cited by 32
Self-citation
Metadata
- Authors
- Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., Andrade, R. J., Bjornsson, E., Dillon, J. F., Hallberg, P., Lucena, M. I., Maitland‐van der Zee, A. H., Martin, J. H., Molokhia, M., Pirmohamed, M., Wadelius, M., Shen, Y., Nelson, M. R., Daly, A. K., & the International Drug‐Induced Liver Injury Consortium (iDILIC)
- Affiliations
- Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA
- National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospital NHS Trust and University of Nottingham Nottingham UK
- Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK
- UGC Digestivo y Servicio de Farmacología Clínica Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Universitario Virgen de la Victoria Universidad de Málaga Málaga Spain
- Division of Gastroenterology and Hepatology Department of Internal Medicine The National University Hospital of Iceland Reykjavik Iceland
- Medical Research Institute University of Dundee Ninewells Hospital Dundee UK
- Department of Medical Sciences and Science for Life Laboratory Uppsala University Uppsala Sweden
- Department of Respiratory Medicine Academic Medical Center (AMC) University of Amsterdam Amsterdam The Netherlands
- School of Medicine and Public Health University of Newcastle Callaghan New South Wales Australia
- School of Population Health and Environmental Sciences Faculty of Life Sciences and Medicine King's College London UK
- Department of Molecular and Clinical Pharmacology University of Liverpool Liverpool UK
- The Herbert Irving Comprehensive Cancer Center Columbia University New York New York USA
- Target Sciences GSK King of Prussia Pennsylvania USA
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2019-03-19
- Volume
- 106
- Issue
- 1
- Pages
- 245-253
- ISSN
- 0009-9236
- 1532-6535
- Cited by
- 91
- References
- 35
- Language
- en
- Funders
- Abbott Laboratories
- Amgen
- Daiichi-Sankyo
- GlaxoSmithKline
- Merck
- Novartis
- Pfizer
- Roche
- Sanofi
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- National Institute for Health Research
- Nottingham University Hospitals NHS Trust
- University of Nottingham
- European Regional Development Fund (P10‐CTS‐6470, FIS PI12/00378, PI16/01748)
- Instituto de Salud Carlos III
- Svenska Läkaresällskapet (2008‐21619)
- Vetenskapsrådet (Medicine 521‐2011‐2440, 521‐2014‐3370, 2017‐00641)
- King’s College London
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Drug‐Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. https://app.cochat.ai/papers/10.1002/cpt.1375
- The paper
- Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., Andrade, R. J., Bjornsson, E., Dillon, J. F., Hallberg, P., Lucena, M. I., Maitland‐van der Zee, A. H., Martin, J. H., Molokhia, M., Pirmohamed, M., Wadelius, M., Shen, Y., Nelson, M. R., Daly, A. K., & the International Drug‐Induced Liver Injury Consortium (iDILIC). (2019). Drug‐Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt.1375
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
