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Drug interactions in man
Abstract
Chronic treatment of experimental animals with phenobarbital resulted in accelerated metabolism of a variety of drugs such as bishydroxycoumarin, diphenylhydantoin, and antipyrine. Evidence for the ability of drugs to stimulate drug metabolism in man has come from the results of studies presented here, showing that phenobarbital decreases the plasma level of diphenylhydantoin and bishydroxycoumarin. The decreased plasma leGel of bishydroxycoumarin in man was correlated with a decreased anticoagulant action of the drug. The ability of a drug to stimulate its own metabolism or the metabolism of another drug appears to have important implications in clinical pharmacologic studies, as weU as to the problem of drug therapy in man.
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Cited by
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
Yamano, S., Tatsuno, J., & Gonzalez, F. J. (1990) · Biochemistry · doi:10.1021/bi00457a031 · Cited by 383
SMITH, J. W., SEIDL, L. G., & CLUFF, L. E. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-65-4-629 · Cited by 305
On-Site Therapeutic Drug Monitoring
Ates, H. C., Roberts, J. A., Lipman, J., Cass, A. E. G., Urban, G. A., & Dincer, C. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2020.03.001 · Cited by 268
Conney, A. H., & Burns, J. J. (1972) · Science · doi:10.1126/science.178.4061.576 · Cited by 260
Self-citationPotentiation by Glucagon of the Hypoprothrombinemic Action of Warfarin
KOCH-WESER, J. (1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-3-331 · Cited by 29
Metadata
- Authors
- Cucinell, S. A., Conney, A. H., Sansur, M., & Burns, J. J.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1965-07
- Volume
- 6
- Issue
- 4
- Pages
- 420-429
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2419040271
- Cited by
- 236
- References
- 0
- FWCI
- 20.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cucinell, S. A., Conney, A. H., Sansur, M., & Burns, J. J. (1965). Drug interactions in man. Clinical Pharmacology & Therapeutics. https://doi.org/10.1002/cpt196564420
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