The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Dose-related sleep disturbances induced by coffee and caffeine
Abstract
In a 13-night sleep laboratory study, each of 18 normal young adult males twice received 1 cup of warm water, 1-, 2-, and 4-cup equivalents of regular coffee, a 4-cup equivalent of decaffeinated coffee, and a 4-cup equivalent of caffeine. All beverages were administered 30 min before bedtime according to a balanced Latin-square design. Regular coffee produced dose-related changes in most standard electroencephalogram-electrooculogram (EEG-EOG) sleep parameters, and the 4-cup equivalents of regular coffee and caffeine produced equivalent effects. Decaffeinated coffee had no effect. Regular coffee and caffeine caused rapid eye movement (REM) sleep to shift to the early part of the night and stages 3 and 4 sleep to shift to the later part. Coffee also produced dose-related changes in several subjects estimates of sleep characteristics. These results suggest that coffee and caffeine may be used in normal subjects to induce symptoms mimicking those of insomnia. Such a tool should promote further understanding of insomnia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and three of these studies [26,43,53] did not implement a washout period with conditions administered across consecutive nights.”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [26]
In the citing paper
“Of the fi ve studies [25,26,31,35,37] investigating the dose-response relationship, four [25,26,31,35] reported heightened perceptions of sleep disruption with larger caffeine doses.”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [26]
Citations
Cites
Handbook for the sixteen personality factor questionnaire (16 PF)
Cattell, R. B., Eber, H. W., & Tatsuoka, M. M. (1970) · Medical Entomology and Zoology · Cited by 1,618
Moruzzi, G. (1972) · Springer eBooks · doi:10.1007/3-540-05462-6_1 · Cited by 516
THE FATE OF CAFFEINE IN MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL
Axelrod, J., & Reichenthal, J. (1953) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)05200-0 · Cited by 242
The subjective assessment of normal sleep patterns
McGhie, A., & Russell, S. M. (1962) · Journal of Mental Science · doi:10.1192/bjp.108.456.642 · Cited by 237
Release of norepinephrine in the central nervous system by theophylline and caffeine
Berkowitz, B. A., Tarver, J., & Spector, S. (1970) · European Journal of Pharmacology · doi:10.1016/0014-2999(70)90158-5 · Cited by 212
Alcohol and Caffeine: Effect on Inferred Visual Dreaming
Gresham, S. C., Webb, W. B., & Williams, R. L. (1963) · Science · doi:10.1126/science.140.3572.1226 · Cited by 112
Self-citationEffects of caffeine on central monoamine neurons
CORRODI, H., Fuxé, K., & JONSSON, G. (1972) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1972.tb08952.x · Cited by 98
Effect of caffeine on sleep - EEG study in late middle-age people
BŘEZINOVÁ, V. (1974) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1974.tb00237.x · Cited by 85
The effect of caffeine and theophylline on the disposition of brain serotonin in the rat
Berkowitz, B. A., & Spector, S. (1971) · European Journal of Pharmacology · doi:10.1016/0014-2999(71)90034-3 · Cited by 81
Determination of Caffeine in Plasma by Gas Chromatography
Grab, F. L., & Reinstein, J. A. (1968) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600571015 · Cited by 38
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–103 of 103
Silva, H., Del Coso, J., & Pickering, C. (2025) · Sports Medicine · doi:10.1007/s40279-025-02245-y · Cited by 21
Sleep patterns of high school students living in Sao Paulo, Brazil
Andrade, M., & Menna-Barreto, L. (2001) · Adolescent Sleep Patterns · doi:10.1017/cbo9780511499999.010 · Cited by 21
LLORET‐LINARES, C., LAFUENTE‐LAFUENTE, C., CHASSANY, O., GREEN, A., DELCEY, V., MOULY, S., & BERGMANN, J. F. (2012) · Nutrition & Dietetics · doi:10.1111/j.1747-0080.2012.01601.x · Cited by 14
Metadata
- Authors
- Karacan, I., Thornby, J. I., Anch, A. M., Booth, G. H., Williams, R. L., & Salis, P. J.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1976-12
- Volume
- 20
- Issue
- 6
- Pages
- 682-689
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2419532383
- Cited by
- 226
- References
- 10
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 8 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 4 · 2012: 8
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- coffee, caffeine, sleep disorders, insomnia, dose-response relationship, REM sleep, sleep stage distribution, decaffeinated coffee
- MeSH terms
- Adult, Caffeine, Clinical Trials as Topic, Coffee, Dose-Response Relationship, Drug, Electroencephalography, Electrooculography, Humans, Male, Sleep, Sleep Stages, Sleep, REM, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
