The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Phenotype and function of human T lymphocyte subsets: Consensus and issues
Open accessAbstract
In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here an account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement. Published 2008 Wiley‐Liss, Inc.
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“Further, these cells re-express CD45RA in combination with markers often stated to reflect “senescence” such as CD57 and KLRG1 (Appay et al. 2008; van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Appay et al. 2008
In the citing paper
“These CMV-specific T cells exhibit a late-stage differentiated phenotype, including loss of co-stimulatory molecules (e.g., CD27 and CD28) and cell-surface proteins associated with homing to lymphoid tissue (e.g., CD62L and CCR7) (Appay et al. 2008; van Lier et al. 2003).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Appay et al. 2008
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“The chemokine receptor CX3CR1 controls homing and anti-viral potencies of CD8 effector-memory T lymphocytes in HIV-infected patients.”
BackgroundInfluentialSelf-citationLineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Phenotypic and functional features of human Th17 cells
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“Recently, the expression of CCR6 and CCR4 have been reported to characterize a homogeneous population of CD4 T cells that produce IL-17 but not IFN-c in humans, referred to as TH17 (29,30).”
BackgroundInfluentialSurface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828 · cited 6×
“Recently, the expression of CCR6 and CCR4 have been reported to characterize a homogeneous population of CD4 T cells that produce IL-17 but not IFN-c in humans, referred to as TH17 (29,30).”
BackgroundInfluentialSelf-citationHIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Betts, M. R. (2006) · Blood · doi:10.1182/blood-2005-12-4818 · Cited by 1,812 · cited 2×
“Specifically, when comparing the HIV-specific T cell response among HIVinfected, clinically defined progressors or long-term nonprogressors, there is a significantly better quality of the CD8 T cell response from the latter group (46,47).”
BackgroundResultT-cell quality in memory and protection: implications for vaccine design
Seder, R. A., Darrah, P. A., & Roederer, M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2274 · Cited by 1,565 · cited 1×
“This property of T cells, distinct from their frequency (magnitude of the response) and phenotype has been referred to as the ‘‘quality’’ of the response (45).”
BackgroundSelf-citationMemory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
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“For instance, CCR5 and CXCR3 expression discriminates CD4 T cells with a TH1 cytokine profile, while CCR3, CCR4, and CRTh2 expression identifies CD4 T cells with a TH2 cytokine profile (27).”
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“major infection demonstrates that the quality of the T cell response is predictive of control following challenge (69).”
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A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Self-citationInflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415
“Receptor Location Cells Bacteria Toll-like receptor 1 Cell membrane Myeloid dendritic cells, monocytes Not specified Toll-like receptor 2 Cell membrane Monocytes, natural killer cells, myeloid dendritic cells,mast cells, T-cells, epithelial cells Porphyromonas gingivalis Escherichia coli Tannerella forsythia Prevotell…”
BackgroundInfluentialAnti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations
Seidel, J. A., Otsuka, A., & Kabashima, K. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00086 · Cited by 1,360
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
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PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
Gros, A., Robbins, P. F., Yao, X., Li, Y. F., Turcotte, S., Tran, E., Wunderlich, J. R., Mixon, A., Farid, S., Dudley, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73639 · Cited by 1,140
“We measured cell surface expression of differentiation markers CD62L, CD45RO, CD27, and CD57 (31), inhibitory receptors PD-1, LAG-3, TIM-3, and BTLA, typically expressed on chronically stimulated CD8 + T cells (23, 24, 32, 33), and costimulatory receptor 4-1BB (28, 34) and IL-2 receptor alpha CD25 (35), which can be u…”
BackgroundInfluential
Metadata
- Authors
- Appay, V., van Lier, R. A. W., Sallusto, F., & Roederer, M.
- Affiliations
- Inserm (FR)
- Institute for Research in Biomedicine (CH)
- National Institutes of Health (US)
- Corresponding author
- Appay, Victor
- Venue
- Cytometry Part A
- Publisher
- Wiley
- Published
- 2008-10-22
- Volume
- 73A
- Issue
- 11
- Pages
- 975-983
- ISSN
- 1552-4922 (ISSN-L)
- 1552-4930
- OpenAlex
- W1574493485
- Cited by
- 729
- References
- 76
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 21 · 2023: 24 · 2022: 19 · 2021: 38 · 2020: 45 · 2019: 46 · 2018: 42 · 2017: 47 · 2016: 52 · 2015: 60 · 2014: 51 · 2013: 69 · 2012: 53
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- Locations
- Cytometry Part A (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- T cell subsets, T cell differentiation, T cell heterogeneity, T cell phenotype, T cell function, immune response, infection
- MeSH terms
- Humans, Inflammation, Lymphocyte Activation, Phenotype, T-Lymphocyte Subsets, Consensus
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